294 related articles for article (PubMed ID: 37453616)
21. Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.
Wang G; Liu Z; Chen T; Wang Z; Yang H; Zheng M; Ren J; Tian G; Yang X; Li L; Li J; Suo J; Zhang R; Jiang X; Terrett NK; Shen J; Xu Y; Jiang H
J Med Chem; 2012 Dec; 55(23):10540-50. PubMed ID: 23137303
[TBL] [Abstract][Full Text] [Related]
22. Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors.
Abdel-Halim M; Tinsley H; Keeton AB; Weam M; Atta NH; Hammam MA; Hefnawy A; Hartmann RW; Engel M; Piazza GA; Abadi AH
Bioorg Chem; 2020 Nov; 104():104322. PubMed ID: 33142429
[TBL] [Abstract][Full Text] [Related]
23. Evaluation of PET radioligands for in vivo visualization of phosphodiesterase 5 (PDE5).
Chekol R; Gheysens O; Cleynhens J; Pokreisz P; Vanhoof G; Ahamed M; Janssens S; Verbruggen A; Bormans G
Nucl Med Biol; 2014 Feb; 41(2):155-62. PubMed ID: 24290227
[TBL] [Abstract][Full Text] [Related]
24. Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development.
Kayık G; Tüzün NŞ; Durdagi S
J Enzyme Inhib Med Chem; 2017 Dec; 32(1):311-330. PubMed ID: 28150511
[TBL] [Abstract][Full Text] [Related]
25. Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors.
Liu J; Zhang X; Chen G; Shao Q; Zou Y; Li Z; Su H; Li M; Xu Y
Eur J Med Chem; 2023 Dec; 262():115893. PubMed ID: 37918035
[TBL] [Abstract][Full Text] [Related]
26. Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer's Disease.
Sánchez-Arias JA; Rabal O; Cuadrado-Tejedor M; de Miguel I; Pérez-González M; Ugarte A; Sáez E; Espelosin M; Ursua S; Haizhong T; Wei W; Musheng X; Garcia-Osta A; Oyarzabal J
ACS Chem Neurosci; 2017 Mar; 8(3):638-661. PubMed ID: 27936591
[TBL] [Abstract][Full Text] [Related]
27. Design and synthesis of novel pyrazolo[3,4-d]pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy.
Ibrahim TS; Hawwas MM; Taher ES; Alhakamy NA; Alfaleh MA; Elagawany M; Elgendy B; Zayed GM; Mohamed MFA; Abdel-Samii ZK; Elshaier YAMM
Bioorg Chem; 2020 Dec; 105():104352. PubMed ID: 33080494
[TBL] [Abstract][Full Text] [Related]
28. Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors.
Ahmed NS; Gary BD; Tinsley HN; Piazza GA; Laufer S; Abadi AH
Arch Pharm (Weinheim); 2011 Mar; 344(3):149-57. PubMed ID: 21384413
[TBL] [Abstract][Full Text] [Related]
29. Effects of PDE5 Inhibitors and sGC Stimulators in a Rat Model of Artificial Ureteral Calculosis.
Sandner P; Tinel H; Affaitati G; Costantini R; Giamberardino MA
PLoS One; 2015; 10(10):e0141477. PubMed ID: 26509272
[TBL] [Abstract][Full Text] [Related]
30. Sub-efficacious doses of phosphodiesterase 4 and 5 inhibitors improve memory in a mouse model of Alzheimer's disease.
Gulisano W; Tropea MR; Arancio O; Palmeri A; Puzzo D
Neuropharmacology; 2018 Aug; 138():151-159. PubMed ID: 29885420
[TBL] [Abstract][Full Text] [Related]
31. Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors.
Ahmed WS; Geethakumari AM; Biswas KH
Biomed Pharmacother; 2021 Feb; 134():111128. PubMed ID: 33348311
[TBL] [Abstract][Full Text] [Related]
32. Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.
Gong X; Wang G; Ren J; Liu Z; Wang Z; Chen T; Yang X; Jiang X; Shen J; Jiang H; Aisa HA; Xu Y; Li J
Bioorg Med Chem Lett; 2013 Sep; 23(17):4944-7. PubMed ID: 23867165
[TBL] [Abstract][Full Text] [Related]
33. Distinct allostery induced in the cyclic GMP-binding, cyclic GMP-specific phosphodiesterase (PDE5) by cyclic GMP, sildenafil, and metal ions.
Biswas KH; Visweswariah SS
J Biol Chem; 2011 Mar; 286(10):8545-8554. PubMed ID: 21193396
[TBL] [Abstract][Full Text] [Related]
34. Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket.
Zhang T; Lai Z; Yuan S; Huang YY; Dong G; Sheng C; Ke H; Luo HB
J Med Chem; 2020 Sep; 63(17):9828-9837. PubMed ID: 32794708
[TBL] [Abstract][Full Text] [Related]
35. Discovery of furyl/thienyl β-carboline derivatives as potent and selective PDE5 inhibitors with excellent vasorelaxant effect.
Zheng H; Wu Y; Sun B; Cheng C; Qiao Y; Jiang Y; Zhao S; Xie Z; Tan J; Lou H
Eur J Med Chem; 2018 Oct; 158():767-780. PubMed ID: 30245400
[TBL] [Abstract][Full Text] [Related]
36. Pharmacophore based virtual screening, molecular docking and biological evaluation to identify novel PDE5 inhibitors with vasodilatory activity.
Mittal A; Paliwal S; Sharma M; Singh A; Sharma S; Yadav D
Bioorg Med Chem Lett; 2014 Jul; 24(14):3137-41. PubMed ID: 24856068
[TBL] [Abstract][Full Text] [Related]
37. Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5).
Ni W; Wang H; Li X; Zheng X; Wang M; Zhang J; Gong Q; Ling D; Mao F; Zhang H; Li J
ACS Chem Neurosci; 2018 Jul; 9(7):1625-1636. PubMed ID: 29616790
[TBL] [Abstract][Full Text] [Related]
38. Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes.
Isidori AM; Cornacchione M; Barbagallo F; Di Grazia A; Barrios F; Fassina L; Monaco L; Giannetta E; Gianfrilli D; Garofalo S; Zhang X; Chen X; Xiang YK; Lenzi A; Pellegrini M; Naro F
Cardiovasc Res; 2015 Jun; 106(3):408-20. PubMed ID: 25852085
[TBL] [Abstract][Full Text] [Related]
39. From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity.
Abdel-Halim M; Sigler S; Racheed NAS; Hefnawy A; Fathalla RK; Hammam MA; Maher A; Maxuitenko Y; Keeton AB; Hartmann RW; Engel M; Piazza GA; Abadi AH
J Med Chem; 2021 Apr; 64(8):4462-4477. PubMed ID: 33793216
[TBL] [Abstract][Full Text] [Related]
40. Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice.
Puzzo D; Loreto C; Giunta S; Musumeci G; Frasca G; Podda MV; Arancio O; Palmeri A
Neurobiol Aging; 2014 Mar; 35(3):520-31. PubMed ID: 24112792
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
