158 related articles for article (PubMed ID: 37455289)
1. From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Visser EJ; Jaishankar P; Sijbesma E; Pennings MAM; Vandenboorn EMF; Guillory X; Neitz RJ; Morrow J; Dutta S; Renslo AR; Brunsveld L; Arkin MR; Ottmann C
Angew Chem Int Ed Engl; 2023 Sep; 62(37):e202308004. PubMed ID: 37455289
[TBL] [Abstract][Full Text] [Related]
2. Discovery of 14-3-3 PPI Stabilizers by Extension of an Amidine-Substituted Thiophene Fragment.
Wu Q; Centorrino F; Guillory X; Wolter M; Ottmann C; Cossar PJ; Brunsveld L
Chembiochem; 2024 Jan; 25(1):e202300636. PubMed ID: 37902676
[TBL] [Abstract][Full Text] [Related]
3. Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
Sijbesma E; Hallenbeck KK; Leysen S; de Vink PJ; Skóra L; Jahnke W; Brunsveld L; Arkin MR; Ottmann C
J Am Chem Soc; 2019 Feb; 141(8):3524-3531. PubMed ID: 30707565
[TBL] [Abstract][Full Text] [Related]
4. Linking Chemical Fragments, "Gluing" Protein Complexes, Connecting across Cultures.
Angew Chem Int Ed Engl; 2023 Dec; 62(52):e202314425. PubMed ID: 37902384
[TBL] [Abstract][Full Text] [Related]
5. Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering.
Wolter M; Valenti D; Cossar PJ; Levy LM; Hristeva S; Genski T; Hoffmann T; Brunsveld L; Tzalis D; Ottmann C
Angew Chem Int Ed Engl; 2020 Nov; 59(48):21520-21524. PubMed ID: 32816380
[TBL] [Abstract][Full Text] [Related]
6. Fragment Screening Yields a Small-Molecule Stabilizer of 14-3-3 Dimers That Modulates Client Protein Interactions.
Brink HJ; Riemens R; Thee S; Beishuizen B; da Costa Pereira D; Wijtmans M; de Esch I; Smit MJ; de Boer AH
Chembiochem; 2022 Sep; 23(17):e202200178. PubMed ID: 35767695
[TBL] [Abstract][Full Text] [Related]
7. Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments.
Konstantinidou M; Visser EJ; Vandenboorn E; Chen S; Jaishankar P; Overmans M; Dutta S; Neitz RJ; Renslo AR; Ottmann C; Brunsveld L; Arkin MR
J Am Chem Soc; 2023 Sep; 145(37):20328-20343. PubMed ID: 37676236
[TBL] [Abstract][Full Text] [Related]
8. A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers.
Kenanova DN; Visser EJ; Virta JM; Sijbesma E; Centorrino F; Vickery HR; Zhong M; Neitz RJ; Brunsveld L; Ottmann C; Arkin MR
ACS Cent Sci; 2023 May; 9(5):937-946. PubMed ID: 37252362
[TBL] [Abstract][Full Text] [Related]
9. Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers.
Sijbesma E; Somsen BA; Miley GP; Leijten-van de Gevel IA; Brunsveld L; Arkin MR; Ottmann C
ACS Chem Biol; 2020 Dec; 15(12):3143-3148. PubMed ID: 33196173
[TBL] [Abstract][Full Text] [Related]
10. Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
Guillory X; Wolter M; Leysen S; Neves JF; Kuusk A; Genet S; Somsen B; Morrow JK; Rivers E; van Beek L; Patel J; Goodnow R; Schoenherr H; Fuller N; Cao Q; Doveston RG; Brunsveld L; Arkin MR; Castaldi P; Boyd H; Landrieu I; Chen H; Ottmann C
J Med Chem; 2020 Jul; 63(13):6694-6707. PubMed ID: 32501690
[TBL] [Abstract][Full Text] [Related]
11. Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers.
Sijbesma E; Hallenbeck KK; Andrei SA; Rust RR; Adriaans JMC; Brunsveld L; Arkin MR; Ottmann C
ACS Med Chem Lett; 2021 Jun; 12(6):976-982. PubMed ID: 34136078
[TBL] [Abstract][Full Text] [Related]
12. Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach.
Somsen BA; Schellekens RJC; Verhoef CJA; Arkin MR; Ottmann C; Cossar PJ; Brunsveld L
J Am Chem Soc; 2023 Mar; 145(12):6741-6752. PubMed ID: 36926879
[TBL] [Abstract][Full Text] [Related]
13. Stabilization of protein-protein interactions in drug discovery.
Andrei SA; Sijbesma E; Hann M; Davis J; O'Mahony G; Perry MWD; Karawajczyk A; Eickhoff J; Brunsveld L; Doveston RG; Milroy LG; Ottmann C
Expert Opin Drug Discov; 2017 Sep; 12(9):925-940. PubMed ID: 28695752
[TBL] [Abstract][Full Text] [Related]
14. Design of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization.
Bosica F; Andrei SA; Neves JF; Brandt P; Gunnarsson A; Landrieu I; Ottmann C; O'Mahony G
Chemistry; 2020 Jun; 26(31):7131-7139. PubMed ID: 32255539
[TBL] [Abstract][Full Text] [Related]
15. Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
Cossar PJ; Wolter M; van Dijck L; Valenti D; Levy LM; Ottmann C; Brunsveld L
J Am Chem Soc; 2021 Jun; 143(22):8454-8464. PubMed ID: 34047554
[TBL] [Abstract][Full Text] [Related]
16. Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex.
Somsen BA; Sijbesma E; Leysen S; Honzejkova K; Visser EJ; Cossar PJ; Obšil T; Brunsveld L; Ottmann C
J Biol Chem; 2023 Jul; 299(7):104855. PubMed ID: 37224961
[TBL] [Abstract][Full Text] [Related]
17. Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products.
Wolter M; de Vink P; Neves JF; Srdanović S; Higuchi Y; Kato N; Wilson A; Landrieu I; Brunsveld L; Ottmann C
J Am Chem Soc; 2020 Jul; 142(27):11772-11783. PubMed ID: 32501683
[TBL] [Abstract][Full Text] [Related]
18. A Supramolecular Stabilizer of the 14-3-3ζ/ERα Protein-Protein Interaction with a Synergistic Mode of Action.
Gigante A; Sijbesma E; Sánchez-Murcia PA; Hu X; Bier D; Bäcker S; Knauer S; Gago F; Ottmann C; Schmuck C
Angew Chem Int Ed Engl; 2020 Mar; 59(13):5284-5287. PubMed ID: 31814236
[TBL] [Abstract][Full Text] [Related]
19. Biophysical and computational fragment-based approaches to targeting protein-protein interactions: applications in structure-guided drug discovery.
Winter A; Higueruelo AP; Marsh M; Sigurdardottir A; Pitt WR; Blundell TL
Q Rev Biophys; 2012 Nov; 45(4):383-426. PubMed ID: 22971516
[TBL] [Abstract][Full Text] [Related]
20. Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
Narayanan D; Tran KT; Pallesen JS; Solbak SMØ; Qin Y; Mukminova E; Luchini M; Vasilyeva KO; González Chichón D; Goutsiou G; Poulsen C; Haapanen N; Popowicz GM; Sattler M; Olagnier D; Gajhede M; Bach A
J Med Chem; 2022 Nov; 65(21):14481-14526. PubMed ID: 36263945
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]