131 related articles for article (PubMed ID: 37459824)
1. Synthesis of and anti-fibrotic effect of pyrazole derivative J-1048: Inhibition of ALK5 as a novel approach to liver fibrosis targeting inflammation.
Yang HX; Guo FY; Lin YC; Wu YL; Nan JX; Jin CH; Lian LH
Bioorg Chem; 2023 Oct; 139():106723. PubMed ID: 37459824
[TBL] [Abstract][Full Text] [Related]
2. The in vitro and in vivo study of a pyrazole derivative, J-1063, as a novel anti-liver fibrosis agent: Synthesis, biological evaluation, and mechanistic analysis.
Zheng GH; Liu J; Guo FY; Zhang ZH; Jiang YJ; Lin YC; Lan XQ; Ren J; Wu YL; Nan JX; Jin CH; Lian LH
Bioorg Chem; 2022 May; 122():105715. PubMed ID: 35279552
[TBL] [Abstract][Full Text] [Related]
3. Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis.
de Gouville AC; Boullay V; Krysa G; Pilot J; Brusq JM; Loriolle F; Gauthier JM; Papworth SA; Laroze A; Gellibert F; Huet S
Br J Pharmacol; 2005 May; 145(2):166-77. PubMed ID: 15723089
[TBL] [Abstract][Full Text] [Related]
4. Enhanced effectivity of an ALK5-inhibitor after cell-specific delivery to hepatic stellate cells in mice with liver injury.
van Beuge MM; Prakash J; Lacombe M; Post E; Reker-Smit C; Beljaars L; Poelstra K
PLoS One; 2013; 8(2):e56442. PubMed ID: 23441194
[TBL] [Abstract][Full Text] [Related]
5. Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes.
Weng HL; Ciuclan L; Liu Y; Hamzavi J; Godoy P; Gaitantzi H; Kanzler S; Heuchel R; Ueberham U; Gebhardt R; Breitkopf K; Dooley S
Hepatology; 2007 Oct; 46(4):1257-70. PubMed ID: 17657819
[TBL] [Abstract][Full Text] [Related]
6. Mechanism of protective effect of phyllanthin against carbon tetrachloride-induced hepatotoxicity and experimental liver fibrosis in mice.
Krithika R; Jyothilakshmi V; Prashantha K; Verma RJ
Toxicol Mech Methods; 2015; 25(9):708-17. PubMed ID: 26337812
[TBL] [Abstract][Full Text] [Related]
7. Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-β1/ALK5/Smad pathway.
Becerra A; Rojas M; Vallejos A; Villegas V; Pérez L; Cabello-Verrugio C; Simon F
Lab Invest; 2017 Sep; 97(9):1033-1046. PubMed ID: 28737766
[TBL] [Abstract][Full Text] [Related]
8. Inhibition of ALK5 as a new approach to treat liver fibrotic diseases.
de Gouville AC; Huet S
Drug News Perspect; 2006 Mar; 19(2):85-90. PubMed ID: 16628263
[TBL] [Abstract][Full Text] [Related]
9. Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.
Laping NJ; Grygielko E; Mathur A; Butter S; Bomberger J; Tweed C; Martin W; Fornwald J; Lehr R; Harling J; Gaster L; Callahan JF; Olson BA
Mol Pharmacol; 2002 Jul; 62(1):58-64. PubMed ID: 12065755
[TBL] [Abstract][Full Text] [Related]
10. Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes.
Yoon JH; Jung SM; Park SH; Kato M; Yamashita T; Lee IK; Sudo K; Nakae S; Han JS; Kim OH; Oh BC; Sumida T; Kuroda M; Ju JH; Jung KC; Park SH; Kim DK; Mamura M
EMBO Mol Med; 2013 Nov; 5(11):1720-39. PubMed ID: 24127404
[TBL] [Abstract][Full Text] [Related]
11. The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection.
Smoktunowicz N; Alexander RE; Franklin L; Williams AE; Holman B; Mercer PF; Jarai G; Scotton CJ; Chambers RC
Dis Model Mech; 2015 Sep; 8(9):1129-39. PubMed ID: 26138704
[TBL] [Abstract][Full Text] [Related]
12. Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function.
Schniewind B; Groth S; Sebens Müerköster S; Sipos B; Schäfer H; Kalthoff H; Fändrich F; Ungefroren H
Oncogene; 2007 Jul; 26(33):4850-62. PubMed ID: 17297450
[TBL] [Abstract][Full Text] [Related]
13. Ginsenoside Rd, a natural production for attenuating fibrogenesis and inflammation in hepatic fibrosis by regulating the ERRα-mediated P2X7r pathway.
Cui L; Tan YJ; Xu SQ; Qin BF; Xiu MX; Zhang X; Shi LQ; Sun HM; Song J
Food Funct; 2023 Jun; 14(12):5606-5619. PubMed ID: 37249244
[TBL] [Abstract][Full Text] [Related]
14. TGF-β Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1α-Induced Epithelial Mesenchymal Transition.
Kim MJ; Park SA; Kim CH; Park SY; Kim JS; Kim DK; Nam JS; Sheen YY
Cell Physiol Biochem; 2016; 38(2):571-88. PubMed ID: 26845171
[TBL] [Abstract][Full Text] [Related]
15. Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses.
Itoh S; Thorikay M; Kowanetz M; Moustakas A; Itoh F; Heldin CH; ten Dijke P
J Biol Chem; 2003 Feb; 278(6):3751-61. PubMed ID: 12446693
[TBL] [Abstract][Full Text] [Related]
16. A Small Dibromotyrosine Derivative Purified From Pseudoceratina Sp. Suppresses TGF-β Responsiveness by Inhibiting TGF-β Type I Receptor Serine/Threonine Kinase Activity.
Chen CL; Kao YC; Yang PH; Sung PJ; Wen ZH; Chen JJ; Huang YB; Chen PY
J Cell Biochem; 2016 Dec; 117(12):2800-2814. PubMed ID: 27153151
[TBL] [Abstract][Full Text] [Related]
17. Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta.
Ungefroren H; Groth S; Ruhnke M; Kalthoff H; Fändrich F
J Biol Chem; 2005 Jan; 280(4):2644-52. PubMed ID: 15546867
[TBL] [Abstract][Full Text] [Related]
18. Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis.
Higashiyama H; Yoshimoto D; Kaise T; Matsubara S; Fujiwara M; Kikkawa H; Asano S; Kinoshita M
Exp Mol Pathol; 2007 Aug; 83(1):39-46. PubMed ID: 17274978
[TBL] [Abstract][Full Text] [Related]
19. Inhibition of TGFβ type I receptor activity facilitates liver regeneration upon acute CCl4 intoxication in mice.
Karkampouna S; Goumans MJ; Ten Dijke P; Dooley S; Kruithof-de Julio M
Arch Toxicol; 2016 Feb; 90(2):347-57. PubMed ID: 25566828
[TBL] [Abstract][Full Text] [Related]
20. RAR-Related Orphan Receptor Gamma (ROR-γ) Mediates Epithelial-Mesenchymal Transition Of Hepatocytes During Hepatic Fibrosis.
Kim SM; Choi JE; Hur W; Kim JH; Hong SW; Lee EB; Lee JH; Li TZ; Sung PS; Yoon SK
J Cell Biochem; 2017 Aug; 118(8):2026-2036. PubMed ID: 27791279
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
