271 related articles for article (PubMed ID: 37506293)
1. Creation of a Peptide Antagonist of the GFRAL-RET Receptor Complex for the Treatment of GDF15-Induced Malaise.
Borner T; Tinsley IC; Milliken BT; Doebley SA; Najjar NR; Kerwood DJ; De Jonghe BC; Hayes MR; Doyle RP
J Med Chem; 2023 Aug; 66(16):11237-11249. PubMed ID: 37506293
[TBL] [Abstract][Full Text] [Related]
2. GDNF family receptor alpha-like antagonist antibody alleviates chemotherapy-induced cachexia in melanoma-bearing mice.
Lee BY; Jeong J; Jung I; Cho H; Jung D; Shin J; Park JK; Park E; Noh S; Shin S; Kang S; Heo JI; Baek MC; Yea K
J Cachexia Sarcopenia Muscle; 2023 Jun; 14(3):1441-1453. PubMed ID: 37017344
[TBL] [Abstract][Full Text] [Related]
3. GDF15 Induces Anorexia through Nausea and Emesis.
Borner T; Shaulson ED; Ghidewon MY; Barnett AB; Horn CC; Doyle RP; Grill HJ; Hayes MR; De Jonghe BC
Cell Metab; 2020 Feb; 31(2):351-362.e5. PubMed ID: 31928886
[TBL] [Abstract][Full Text] [Related]
4. Identification of GDF15 peptide fragments inhibiting GFRAL receptor signaling.
Alexopoulou F; Buch-Månson N; Pedersen SL; Vrang N; Fink LN; Strømgaard K
Peptides; 2023 Oct; 168():171063. PubMed ID: 37495041
[TBL] [Abstract][Full Text] [Related]
5. Uniting GDF15 and GFRAL: Therapeutic Opportunities in Obesity and Beyond.
Mullican SE; Rangwala SM
Trends Endocrinol Metab; 2018 Aug; 29(8):560-570. PubMed ID: 29866502
[TBL] [Abstract][Full Text] [Related]
6. The GDF15-GFRAL axis mediates chemotherapy-induced fatigue in mice.
Chelette B; Chidomere CL; Dantzer R
Brain Behav Immun; 2023 Feb; 108():45-54. PubMed ID: 36427806
[TBL] [Abstract][Full Text] [Related]
7. The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling.
Worth AA; Shoop R; Tye K; Feetham CH; D'Agostino G; Dodd GT; Reimann F; Gribble FM; Beebe EC; Dunbar JD; Alexander-Chacko JT; Sindelar DK; Coskun T; Emmerson PJ; Luckman SM
Elife; 2020 Jul; 9():. PubMed ID: 32723474
[TBL] [Abstract][Full Text] [Related]
8. GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
Yang L; Chang CC; Sun Z; Madsen D; Zhu H; Padkjær SB; Wu X; Huang T; Hultman K; Paulsen SJ; Wang J; Bugge A; Frantzen JB; Nørgaard P; Jeppesen JF; Yang Z; Secher A; Chen H; Li X; John LM; Shan B; He Z; Gao X; Su J; Hansen KT; Yang W; Jørgensen SB
Nat Med; 2017 Oct; 23(10):1158-1166. PubMed ID: 28846099
[TBL] [Abstract][Full Text] [Related]
9. LPS induces rapid increase in GDF15 levels in mice, rats, and humans but is not required for anorexia in mice.
Patel AR; Frikke-Schmidt H; Bezy O; Sabatini PV; Rittig N; Jessen N; Myers MG; Seeley RJ
Am J Physiol Gastrointest Liver Physiol; 2022 Feb; 322(2):G247-G255. PubMed ID: 34935522
[TBL] [Abstract][Full Text] [Related]
10. GDF15: A Hormone Conveying Somatic Distress to the Brain.
Lockhart SM; Saudek V; O'Rahilly S
Endocr Rev; 2020 Aug; 41(4):. PubMed ID: 32310257
[TBL] [Abstract][Full Text] [Related]
11. GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS.
Tsai VW; Zhang HP; Manandhar R; Schofield P; Christ D; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Brown DA; Breit SN
Int J Obes (Lond); 2019 Dec; 43(12):2370-2380. PubMed ID: 31152154
[TBL] [Abstract][Full Text] [Related]
12. The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases.
Tsai VWW; Husaini Y; Sainsbury A; Brown DA; Breit SN
Cell Metab; 2018 Sep; 28(3):353-368. PubMed ID: 30184485
[TBL] [Abstract][Full Text] [Related]
13. GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss.
Borner T; Wald HS; Ghidewon MY; Zhang B; Wu Z; De Jonghe BC; Breen D; Grill HJ
Cell Rep; 2020 Apr; 31(3):107543. PubMed ID: 32320650
[TBL] [Abstract][Full Text] [Related]
14. The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.
Emmerson PJ; Wang F; Du Y; Liu Q; Pickard RT; Gonciarz MD; Coskun T; Hamang MJ; Sindelar DK; Ballman KK; Foltz LA; Muppidi A; Alsina-Fernandez J; Barnard GC; Tang JX; Liu X; Mao X; Siegel R; Sloan JH; Mitchell PJ; Zhang BB; Gimeno RE; Shan B; Wu X
Nat Med; 2017 Oct; 23(10):1215-1219. PubMed ID: 28846098
[TBL] [Abstract][Full Text] [Related]
15. GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.
Mullican SE; Lin-Schmidt X; Chin CN; Chavez JA; Furman JL; Armstrong AA; Beck SC; South VJ; Dinh TQ; Cash-Mason TD; Cavanaugh CR; Nelson S; Huang C; Hunter MJ; Rangwala SM
Nat Med; 2017 Oct; 23(10):1150-1157. PubMed ID: 28846097
[TBL] [Abstract][Full Text] [Related]
16. Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice.
Suriben R; Chen M; Higbee J; Oeffinger J; Ventura R; Li B; Mondal K; Gao Z; Ayupova D; Taskar P; Li D; Starck SR; Chen HH; McEntee M; Katewa SD; Phung V; Wang M; Kekatpure A; Lakshminarasimhan D; White A; Olland A; Haldankar R; Solloway MJ; Hsu JY; Wang Y; Tang J; Lindhout DA; Allan BB
Nat Med; 2020 Aug; 26(8):1264-1270. PubMed ID: 32661391
[TBL] [Abstract][Full Text] [Related]
17. GDF15 acts synergistically with liraglutide but is not necessary for the weight loss induced by bariatric surgery in mice.
Frikke-Schmidt H; Hultman K; Galaske JW; Jørgensen SB; Myers MG; Seeley RJ
Mol Metab; 2019 Mar; 21():13-21. PubMed ID: 30685336
[TBL] [Abstract][Full Text] [Related]
18. Body weight regulation via MT1-MMP-mediated cleavage of GFRAL.
Chow CFW; Guo X; Asthana P; Zhang S; Wong SKK; Fallah S; Che S; Gurung S; Wang Z; Lee KB; Ge X; Yuan S; Xu H; Ip JPK; Jiang Z; Zhai L; Wu J; Zhang Y; Mahato AK; Saarma M; Lin CY; Kwan HY; Huang T; Lyu A; Zhou Z; Bian ZX; Wong HLX
Nat Metab; 2022 Feb; 4(2):203-212. PubMed ID: 35177851
[TBL] [Abstract][Full Text] [Related]
19. The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?
Breit SN; Brown DA; Tsai VW
Annu Rev Physiol; 2021 Feb; 83():127-151. PubMed ID: 33228454
[TBL] [Abstract][Full Text] [Related]
20. Screening study of anti-emetics to improve GDF15-induced malaise and anorexia: Implications for emesis control.
Borner T; Doebley SA; Furst CD; Pataro AM; Halas JG; Gao X; Choi GK; Ramadan SA; Chow A; De Jonghe BC
Physiol Behav; 2023 Aug; 267():114229. PubMed ID: 37164246
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
