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7. Accelerating therapeutics development during a pandemic: population pharmacokinetics of the long-acting antibody combination AZD7442 (tixagevimab/cilgavimab) in the prophylaxis and treatment of COVID-19. Clegg LE; Stepanov O; Schmidt H; Tang W; Zhang H; Webber C; Cohen TS; Esser MT; Någård M Antimicrob Agents Chemother; 2024 May; 68(5):e0158723. PubMed ID: 38534112 [TBL] [Abstract][Full Text] [Related]
8. Comparative Pharmacokinetics of Tixagevimab/Cilgavimab (AZD7442) Administered Intravenously Versus Intramuscularly in Symptomatic SARS-CoV-2 Infection. Bender Ignacio RA; Wohl DA; Arends R; Pilla Reddy V; Mu Y; Javan AC; Hughes MD; Eron JJ; Currier JS; Smith D; Chew KW; Gibbs M; Fletcher CV Clin Pharmacol Ther; 2022 Dec; 112(6):1207-1213. PubMed ID: 35797235 [TBL] [Abstract][Full Text] [Related]
9. The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans. Loo YM; McTamney PM; Arends RH; Abram ME; Aksyuk AA; Diallo S; Flores DJ; Kelly EJ; Ren K; Roque R; Rosenthal K; Streicher K; Tuffy KM; Bond NJ; Cornwell O; Bouquet J; Cheng LI; Dunyak J; Huang Y; Rosenbaum AI; Pilla Reddy V; Andersen H; Carnahan RH; Crowe JE; Kuehne AI; Herbert AS; Dye JM; Bright H; Kallewaard NL; Pangalos MN; Esser MT Sci Transl Med; 2022 Mar; 14(635):eabl8124. PubMed ID: 35076282 [TBL] [Abstract][Full Text] [Related]
11. Efficacy and safety of intramuscular administration of tixagevimab-cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial. Montgomery H; Hobbs FDR; Padilla F; Arbetter D; Templeton A; Seegobin S; Kim K; Campos JAS; Arends RH; Brodek BH; Brooks D; Garbes P; Jimenez J; Koh GCKW; Padilla KW; Streicher K; Viani RM; Alagappan V; Pangalos MN; Esser MT; Lancet Respir Med; 2022 Oct; 10(10):985-996. PubMed ID: 35688164 [TBL] [Abstract][Full Text] [Related]
12. Safety and Efficacy of Combined Tixagevimab and Cilgavimab Administered Intramuscularly or Intravenously in Nonhospitalized Patients With COVID-19: 2 Randomized Clinical Trials. Bender Ignacio RA; Chew KW; Moser C; Currier JS; Eron JJ; Javan AC; Giganti MJ; Aga E; Gibbs M; Tchouakam Kouekam H; Johnsson E; Esser MT; Hoover K; Neytman G; Newell M; Daar ES; Fischer W; Fletcher CV; Li JZ; Greninger AL; Coombs RW; Hughes MD; Smith D; Wohl DA; JAMA Netw Open; 2023 Apr; 6(4):e2310039. PubMed ID: 37099295 [TBL] [Abstract][Full Text] [Related]
13. Breakthrough SARS-CoV-2 Infections in the PROVENT Prevention Trial Were Not Associated With AZD7442 (Tixagevimab/Cilgavimab) Resistant Variants. Tuffy KM; Ahani B; Aksyuk AA; Avila M; Brady T; Kijak GH; Koh G; Levin MJ; Roe TL; Schuko N; Thissen J; Ustianowski A; Zhang T; Kelly EJ; Streicher K J Infect Dis; 2023 Oct; 228(8):1055-1059. PubMed ID: 37280116 [TBL] [Abstract][Full Text] [Related]
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15. SARS-CoV-2 pre-exposure prophylaxis with tixagevimab/cilgavimab (AZD7442) provides protection in inborn errors of immunity with antibody defects: a real-world experience. Pulvirenti F; Garzi G; Milito C; Sculco E; Sciannamea M; Napoli A; Cinti L; Roberto P; Punziano A; Carrabba M; Piano Mortari E; Carsetti R; Antonelli G; Quinti I Front Immunol; 2023; 14():1249462. PubMed ID: 37954618 [TBL] [Abstract][Full Text] [Related]
16. A Phase 1 Randomized, Double-Blind, Placebo-Controlled Trial to Assess the Safety, Tolerability, and Pharmacokinetics of a Respiratory Syncytial Virus Neutralizing Monoclonal Antibody MK-1654 in Healthy Adults. Aliprantis AO; Wolford D; Caro L; Maas BM; Ma H; Montgomery DL; Sterling LM; Hunt A; Cox KS; Vora KA; Roadcap BA; Railkar RA; Lee AW; Stoch SA; Lai E Clin Pharmacol Drug Dev; 2021 May; 10(5):556-566. PubMed ID: 33125189 [TBL] [Abstract][Full Text] [Related]
17. Analysis of SARS-CoV-2 Emergent Variants Following AZD7442 (Tixagevimab/Cilgavimab) for Early Outpatient Treatment of COVID-19 (TACKLE Trial). Kijak GH; Ahani B; Arbetter D; Chuecos F; Gopalakrishnan V; Beloor J; Brady T; Nguyen A; Roe TL; Schuko N; Zhang T; Hobbs FDR; Padilla F; Kelly EJ; Montgomery H; Streicher K Infect Dis Ther; 2023 Dec; 12(12):2691-2707. PubMed ID: 37914983 [TBL] [Abstract][Full Text] [Related]
18. Randomized, placebo-controlled, single-blind phase 1 studies of the safety, tolerability, and pharmacokinetics of BRII-196 and BRII-198, SARS-CoV-2 spike-targeting monoclonal antibodies with an extended half-life in healthy adults. Hao X; Zhang Z; Ma J; Cheng L; Ji Y; Liu Y; Zhao D; Zhang W; Li C; Yan L; Margolis D; Zhu Q; Zhang Y; Zhang F Front Pharmacol; 2022; 13():983505. PubMed ID: 36147329 [No Abstract] [Full Text] [Related]
19. Association Between AZD7442 (Tixagevimab-Cilgavimab) Administration and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection, Hospitalization, and Mortality. Kertes J; Shapiro Ben David S; Engel-Zohar N; Rosen K; Hemo B; Kantor A; Adler L; Shamir Stein N; Mizrahi Reuveni M; Shahar A Clin Infect Dis; 2023 Feb; 76(3):e126-e132. PubMed ID: 35904210 [TBL] [Abstract][Full Text] [Related]
20. Pharmacokinetics, Safety, and Tolerability of Anti-SARS-CoV-2 Monoclonal Antibody, Sotrovimab, Delivered Intravenously or Intramuscularly in Japanese and Caucasian Healthy Volunteers. Nader A; Alexander E; Brintziki D; Haggag AZ; Harrison SA; Hawes IA; Hezareh M; Lippa AM; Okamasa A; Okour M; Okuda N; Sager JE; Segal S; Shida Y; Skingsley A; Williams R; Yoon EY; Austin D Clin Pharmacokinet; 2024 Jan; 63(1):57-68. PubMed ID: 37955825 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]