BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

152 related articles for article (PubMed ID: 37536209)

  • 1. Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold.
    Novotna K; Thomas AG; Stepanek O; Murphy B; Hin N; Skacel J; Mueller L; Tenora L; Pal A; Alt J; Wu Y; Paule J; Rais R; Slusher BS; Tsukamoto T
    Eur J Med Chem; 2023 Nov; 259():115674. PubMed ID: 37536209
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of neutral sphingomyelinase 2 reduces extracellular vesicle release from neurons, oligodendrocytes, and activated microglial cells following acute brain injury.
    Tallon C; Picciolini S; Yoo SW; Thomas AG; Pal A; Alt J; Carlomagno C; Gualerzi A; Rais R; Haughey NJ; Bedoni M; Slusher BS
    Biochem Pharmacol; 2021 Dec; 194():114796. PubMed ID: 34678224
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound.
    Yoo SW; Waheed AA; Deme P; Tohumeken S; Rais R; Smith MD; DeMarino C; Calabresi PA; Kashanchi F; Freed EO; Slusher BS; Haughey NJ
    Proc Natl Acad Sci U S A; 2023 Jul; 120(28):e2219543120. PubMed ID: 37406092
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV.
    Zhu X; Hollinger KR; Huang Y; Borjabad A; Kim BH; Arab T; Thomas AG; Moniruzzaman M; Lovell L; Turchinovich A; Witwer KW; Volsky DJ; Haughey NJ; Slusher BS
    Neurobiol Dis; 2022 Jul; 169():105734. PubMed ID: 35462006
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A novel and potent brain penetrant inhibitor of extracellular vesicle release.
    Rojas C; Sala M; Thomas AG; Datta Chaudhuri A; Yoo SW; Li Z; Dash RP; Rais R; Haughey NJ; Nencka R; Slusher B
    Br J Pharmacol; 2019 Oct; 176(19):3857-3870. PubMed ID: 31273753
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease.
    Šála M; Hollinger KR; Thomas AG; Dash RP; Tallon C; Veeravalli V; Lovell L; Kögler M; Hřebabecký H; Procházková E; Nešuta O; Donoghue A; Lam J; Rais R; Rojas C; Slusher BS; Nencka R
    J Med Chem; 2020 Jun; 63(11):6028-6056. PubMed ID: 32298582
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold.
    Stepanek O; Hin N; Thomas AG; Dash RP; Alt J; Rais R; Rojas C; Slusher BS; Tsukamoto T
    Eur J Med Chem; 2019 May; 170():276-289. PubMed ID: 30921693
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in murine Alzheimer's disease.
    Tallon C; Bell BJ; Malvankar MM; Deme P; Nogueras-Ortiz C; Eren E; Thomas AG; Hollinger KR; Pal A; Mustapic M; Huang M; Coleman K; Joe TR; Rais R; Haughey NJ; Kapogiannis D; Slusher BS
    Res Sq; 2023 Jul; ():. PubMed ID: 37502930
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer's disease mouse model.
    Tallon C; Bell BJ; Malvankar MM; Deme P; Nogueras-Ortiz C; Eren E; Thomas AG; Hollinger KR; Pal A; Mustapic M; Huang M; Coleman K; Joe TR; Rais R; Haughey NJ; Kapogiannis D; Slusher BS
    Transl Neurodegener; 2023 Dec; 12(1):56. PubMed ID: 38049923
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties.
    Figuera-Losada M; Stathis M; Dorskind JM; Thomas AG; Bandaru VV; Yoo SW; Westwood NJ; Rogers GW; McArthur JC; Haughey NJ; Slusher BS; Rojas C
    PLoS One; 2015; 10(5):e0124481. PubMed ID: 26010541
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Neuronal deletion of nSMase2 reduces the production of Aβ and directly protects neurons.
    Tohumeken S; Deme P; Yoo SW; Gupta S; Rais R; Slusher BS; Haughey NJ
    Neurobiol Dis; 2023 Feb; 177():105987. PubMed ID: 36603748
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Interaction of Synaptosomal-Associated Protein 25 with Neutral Sphingomyelinase 2: Functional Impact on the Sphingomyelin Pathway.
    Won JH; Jeon HJ; Kim SK; Shin IC; Jang JM; Ha HC; Back MJ; Kim DK
    Neuroscience; 2020 Feb; 427():1-15. PubMed ID: 31765623
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 7 H-Pyrrolo[2,3- d]pyrimidin-4-amine-Based Inhibitors of Calcium-Dependent Protein Kinase 1 Have Distinct Inhibitory and Oral Pharmacokinetic Characteristics Compared with 1 H-Pyrazolo[3,4- d]pyrimidin-4-amine-Based Inhibitors.
    Vidadala RSR; Golkowski M; Hulverson MA; Choi R; McCloskey MC; Whitman GR; Huang W; Arnold SLM; Barrett LK; Fan E; Merritt EA; Van Voorhis WC; Ojo KK; Maly DJ
    ACS Infect Dis; 2018 Apr; 4(4):516-522. PubMed ID: 29522315
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification and evaluation of neutral sphingomyelinase 2 inhibitors.
    Lee DH; Kim SH; Ahn KH; Kim SK; Choi JM; Ji JE; Won JH; Park YH; Lim C; Kim S; Kim DK
    Arch Pharm Res; 2011 Feb; 34(2):229-36. PubMed ID: 21380806
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and biological evaluation of some novel pyrazolopyrimidines incorporating a benzothiazole ring system.
    Azam MA; Dharanya L; Mehta CC; Sachdeva S
    Acta Pharm; 2013 Mar; 63(1):19-30. PubMed ID: 23482310
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Regulated translocation of neutral sphingomyelinase-2 to the plasma membrane drives insulin resistance in steatotic hepatocytes.
    El-Amouri S; Karakashian A; Bieberich E; Nikolova-Karakashian M
    J Lipid Res; 2023 Oct; 64(10):100435. PubMed ID: 37640282
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Neutral sphingomyelinase-2 and cardiometabolic diseases.
    Sindhu S; Leung YH; Arefanian H; Madiraju SRM; Al-Mulla F; Ahmad R; Prentki M
    Obes Rev; 2021 Aug; 22(8):e13248. PubMed ID: 33738905
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells.
    Marchesini N; Osta W; Bielawski J; Luberto C; Obeid LM; Hannun YA
    J Biol Chem; 2004 Jun; 279(24):25101-11. PubMed ID: 15051724
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists.
    Ivachtchenko AV; Golovina ES; Kadieva MG; Kysil VM; Mitkin OD; Tkachenko SE; Okun I
    Bioorg Med Chem; 2011 Feb; 19(4):1482-91. PubMed ID: 21277782
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1.
    Cinq-Frais C; Coatrieux C; Grazide MH; Hannun YA; Nègre-Salvayre A; Salvayre R; Augé N
    Biochim Biophys Acta; 2013 Aug; 1831(8):1344-56. PubMed ID: 23651497
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.