BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

140 related articles for article (PubMed ID: 37536217)

  • 1. Discovery of potent and selective HPK1 inhibitors based on the 2,4-disubstituted pyrimidine scaffold with immune modulatory properties for ameliorating T cell exhaustion.
    Zeng S; Zeng M; Yuan S; He L; Jin Y; Huang J; Zhang M; Yang M; Pan Y; Wang Z; Chen Y; Xu X; Huang W
    Bioorg Chem; 2023 Oct; 139():106728. PubMed ID: 37536217
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody.
    Zeng S; Wu M; Jin Y; Ye Y; Xia H; Chen X; Che J; Wang Z; Wu Y; Dong X; Chen Y; Huang W
    Eur J Med Chem; 2024 Mar; 267():116206. PubMed ID: 38350360
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors.
    Wu F; Li H; An Q; Sun Y; Yu J; Cao W; Sun P; Diao X; Meng L; Xu S
    Eur J Med Chem; 2023 Jun; 254():115355. PubMed ID: 37062169
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of Macrocycle-Based HPK1 Inhibitors for T-Cell-Based Immunotherapy.
    Wang MS; Wang ZZ; Li ZL; Gong Y; Duan CX; Cheng QH; Huang W; Yang GF
    J Med Chem; 2023 Jan; 66(1):611-626. PubMed ID: 36542759
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design and synthesis of 1H-pyrazolo[3,4-d]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors.
    Zhang J; Li Y; Tang H; Zhou Q; Tong L; Ding J; Xie H; Xiong B; Liu T
    Bioorg Chem; 2023 Nov; 140():106811. PubMed ID: 37659145
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors.
    Qiu X; Liu R; Ling H; Zhou Y; Ren X; Zhou F; Zhang J; Huang W; Wang Z; Ding K
    Eur J Med Chem; 2024 Apr; 269():116310. PubMed ID: 38479166
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of diaminotriazine carboxamides as potent inhibitors of hematopoetic progenitor kinase 1.
    Zhou L; Ye X; Wang K; Shen H; Wang T; Zhang X; Jiang S; Xiao Y; Zhang K
    Bioorg Chem; 2023 Sep; 138():106682. PubMed ID: 37339563
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy.
    Malchow S; Korepanova A; Panchal SC; McClure RA; Longenecker KL; Qiu W; Zhao H; Cheng M; Guo J; Klinge KL; Trusk P; Pratt SD; Li T; Kurnick MD; Duan L; Shoemaker AR; Gopalakrishnan SM; Warder SE; Shotwell JB; Lai A; Sun C; Osuma AT; Pappano WN
    ACS Chem Biol; 2022 Mar; 17(3):556-566. PubMed ID: 35188729
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibitors of immuno-oncology target HPK1 - a patent review (2016 to 2020).
    Linney ID; Kaila N
    Expert Opin Ther Pat; 2021 Oct; 31(10):893-910. PubMed ID: 33956554
    [No Abstract]   [Full Text] [Related]  

  • 10. Development of a series of quinazoline-2,5-diamine derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors.
    Shi H; Tang H; Li Y; Chen D; Liu T; Chen Y; Wang X; Chen L; Wang Y; Xie H; Xiong B
    Eur J Med Chem; 2023 Feb; 248():115064. PubMed ID: 36621137
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay.
    Wang W; Mevellec L; Liu A; Struble G; Miller R; Allen SJ; Federowicz K; Wroblowski B; Vialard J; Ahn K; Krosky D
    Biochemistry; 2021 Oct; 60(41):3114-3124. PubMed ID: 34608799
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The development of small-molecule inhibitors targeting HPK1.
    Zhou L; Wang T; Zhang K; Zhang X; Jiang S
    Eur J Med Chem; 2022 Dec; 244():114819. PubMed ID: 36209628
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of quinazoline HPK1 inhibitors with high cellular potency.
    Toure M; Johnson T; Li B; Schmidt R; Ma H; Neagu C; Lopez AU; Wang Y; Guler S; Xiao Y; Henkes R; Ho K; Zhang S; Chu CL; Gundra UM; Porichis F; Li L; Maurer CK; Fang Z; Musil D; DiPoto M; Friis E; Jones R; Jones C; Cummings J; Chekler E; Tanzer EM; Huck B; Sherer B
    Bioorg Med Chem; 2023 Sep; 92():117423. PubMed ID: 37531921
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors.
    Lacey BM; Xu Z; Chai X; Laskey J; Fradera X; Mittal P; Mishra S; Piesvaux J; Saradjian P; Shaffer L; Vassileva G; Gerdt C; Wang Y; Ferguson H; Smith DM; Ballard J; Wells S; Jain R; Mueller U; Addona G; Kariv I; Methot JL; Bittinger M; Ranganath S; Mcleod R; Pasternak A; Miller JR; Xu H
    SLAS Discov; 2021 Jan; 26(1):88-99. PubMed ID: 32844715
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes.
    Ma W; Xia C; Ling P; Qiu M; Luo Y; Tan TH; Liu M
    Oncogene; 2001 Mar; 20(14):1703-14. PubMed ID: 11313918
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses.
    Shui JW; Boomer JS; Han J; Xu J; Dement GA; Zhou G; Tan TH
    Nat Immunol; 2007 Jan; 8(1):84-91. PubMed ID: 17115060
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hematopoietic Progenitor Kinase 1 in Tumor Immunology: A Medicinal Chemistry Perspective.
    Zhu Q; Chen N; Tian X; Zhou Y; You Q; Xu X
    J Med Chem; 2022 Jun; 65(12):8065-8090. PubMed ID: 35696642
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1.
    Arnold R; Patzak IM; Neuhaus B; Vancauwenbergh S; Veillette A; Van Lint J; Kiefer F
    Mol Cell Biol; 2005 Mar; 25(6):2364-83. PubMed ID: 15743830
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function.
    Wang Y; Zhang K; Georgiev P; Wells S; Xu H; Lacey BM; Xu Z; Laskey J; Mcleod R; Methot JL; Bittinger M; Pasternak A; Ranganath S
    PLoS One; 2020; 15(12):e0243145. PubMed ID: 33270695
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies.
    Si J; Shi X; Sun S; Zou B; Li Y; An D; Lin X; Gao Y; Long F; Pang B; Liu X; Liu T; Chi W; Chen L; Dimitrov DS; Sun Y; Du X; Yin W; Gao G; Min J; Wei L; Liao X
    Cancer Cell; 2020 Oct; 38(4):551-566.e11. PubMed ID: 32860752
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.