142 related articles for article (PubMed ID: 37536217)
21. Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies.
Si J; Shi X; Sun S; Zou B; Li Y; An D; Lin X; Gao Y; Long F; Pang B; Liu X; Liu T; Chi W; Chen L; Dimitrov DS; Sun Y; Du X; Yin W; Gao G; Min J; Wei L; Liao X
Cancer Cell; 2020 Oct; 38(4):551-566.e11. PubMed ID: 32860752
[TBL] [Abstract][Full Text] [Related]
22. Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.
Vara BA; Levi SM; Achab A; Candito DA; Fradera X; Lesburg CA; Kawamura S; Lacey BM; Lim J; Methot JL; Xu Z; Xu H; Smith DM; Piesvaux JA; Miller JR; Bittinger M; Ranganath SH; Bennett DJ; DiMauro EF; Pasternak A
ACS Med Chem Lett; 2021 Apr; 12(4):653-661. PubMed ID: 33859804
[TBL] [Abstract][Full Text] [Related]
23. The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function.
Hernandez S; Qing J; Thibodeau RH; Du X; Park S; Lee HM; Xu M; Oh S; Navarro A; Roose-Girma M; Newman RJ; Warming S; Nannini M; Sampath D; Kim JM; Grogan JL; Mellman I
Cell Rep; 2018 Oct; 25(1):80-94. PubMed ID: 30282040
[TBL] [Abstract][Full Text] [Related]
24. Current strategies for targeting HPK1 in cancer and the barriers to preclinical progress.
Chen H; Guan X; He C; Lu T; Lin X; Liao X
Expert Opin Ther Targets; 2024 Apr; 28(4):237-250. PubMed ID: 38650383
[TBL] [Abstract][Full Text] [Related]
25. Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation.
Johnson E; McTigue M; Gallego RA; Johnson TW; Timofeevski S; Maestre M; Fisher TS; Kania R; Sawasdikosol S; Burakoff S; Cronin CN
J Biol Chem; 2019 Jun; 294(23):9029-9036. PubMed ID: 31018963
[TBL] [Abstract][Full Text] [Related]
26. Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor.
You D; Hillerman S; Locke G; Chaudhry C; Stromko C; Murtaza A; Fan Y; Koenitzer J; Chen Y; Briceno S; Bhadra R; Duperret E; Gullo-Brown J; Gao C; Zhao D; Feder J; Curtin J; Degnan AP; Kumi G; Wittman M; Johnson BM; Parrish KE; Gokulrangan G; Morrison J; Quigley M; Hunt JT; Salter-Cid L; Lees E; Sanjuan MA; Liu J
J Immunother Cancer; 2021 Jan; 9(1):. PubMed ID: 33408094
[TBL] [Abstract][Full Text] [Related]
27. HPK1 as a novel target for cancer immunotherapy.
Sawasdikosol S; Zha R; Yang B; Burakoff S
Immunol Res; 2012 Dec; 54(1-3):262-5. PubMed ID: 22477524
[TBL] [Abstract][Full Text] [Related]
28. MAP4K Family Kinases in Immunity and Inflammation.
Chuang HC; Wang X; Tan TH
Adv Immunol; 2016; 129():277-314. PubMed ID: 26791862
[TBL] [Abstract][Full Text] [Related]
29. Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
Chan BK; Seward E; Lainchbury M; Brewer TF; An L; Blench T; Cartwright MW; Chan GKY; Choo EF; Drummond J; Elliott RL; Gancia E; Gazzard L; Hu B; Jones GE; Luo X; Madin A; Malhotra S; Moffat JG; Pang J; Salphati L; Sneeringer CJ; Stivala CE; Wei B; Wang W; Wu P; Heffron TP
ACS Med Chem Lett; 2022 Jan; 13(1):84-91. PubMed ID: 35059127
[TBL] [Abstract][Full Text] [Related]
30. Discovery of Novel HPK1 Inhibitors Through Structure-Based Virtual Screening.
Ge H; Peng L; Sun Z; Liu H; Shen Y; Yao X
Front Pharmacol; 2022; 13():850855. PubMed ID: 35370676
[TBL] [Abstract][Full Text] [Related]
31. Theoretical Studies on Selectivity of HPK1/JAK1 Inhibitors by Molecular Dynamics Simulations and Free Energy Calculations.
Ge H; Tang C; Pan Y; Yao X
Int J Mol Sci; 2023 Jan; 24(3):. PubMed ID: 36768974
[TBL] [Abstract][Full Text] [Related]
32. Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region.
Li T; Yu XJ; Zhang GY
FEBS Lett; 2008 Jun; 582(13):1894-900. PubMed ID: 18498770
[TBL] [Abstract][Full Text] [Related]
33. Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation.
Feng D; Liu B; Chen Z; Xu J; Geng M; Duan W; Ai J; Zhang H
J Biomol Struct Dyn; 2024 Jan; ():1-13. PubMed ID: 38198294
[TBL] [Abstract][Full Text] [Related]
34. Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models.
Setsu G; Goto M; Ito K; Taira T; Miyamoto M; Watanabe T; Taniguchi T; Umezaki Y; Nakazawa Y; Uesugi S; Mori K; Horiuchi T; Obuchi W; Minami M; Shimada T; Wada C; Yoshida T; Higuchi S
Eur J Pharmacol; 2023 Dec; 961():176184. PubMed ID: 37944847
[TBL] [Abstract][Full Text] [Related]
35. Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes.
Schulze-Luehrmann J; Santner-Nanan B; Jha MK; Schimpl A; Avots A; Serfling E
Blood; 2002 Aug; 100(3):954-60. PubMed ID: 12130508
[TBL] [Abstract][Full Text] [Related]
36. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade.
Hu MC; Qiu WR; Wang X; Meyer CF; Tan TH
Genes Dev; 1996 Sep; 10(18):2251-64. PubMed ID: 8824585
[TBL] [Abstract][Full Text] [Related]
37. Hematopoietic progenitor kinase 1 is a negative regulator of dendritic cell activation.
Alzabin S; Bhardwaj N; Kiefer F; Sawasdikosol S; Burakoff S
J Immunol; 2009 May; 182(10):6187-94. PubMed ID: 19414772
[TBL] [Abstract][Full Text] [Related]
38. A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1.
Ensenat D; Yao Z; Wang XS; Kori R; Zhou G; Lee SC; Tan TH
J Biol Chem; 1999 Nov; 274(48):33945-50. PubMed ID: 10567356
[TBL] [Abstract][Full Text] [Related]
39. Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade.
Zhou G; Lee SC; Yao Z; Tan TH
J Biol Chem; 1999 May; 274(19):13133-8. PubMed ID: 10224067
[TBL] [Abstract][Full Text] [Related]
40. Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors.
Xie C; Liu B; Song Z; Yang Y; Dai M; Gao Y; Yao Y; Ding C; Ai J; Zhang A
J Med Chem; 2023 Dec; 66(23):16201-16221. PubMed ID: 37990878
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]