BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

129 related articles for article (PubMed ID: 37536263)

  • 1. Discovery and biological evaluation of cholic acid derivatives as potent TGR5 positive allosteric modulators.
    Li Y; Sun J; Wang X; Luo Z; Shao X; Li Y; Cao Q; Zhao S; Qian M; Chen X
    Bioorg Med Chem; 2023 Sep; 92():117418. PubMed ID: 37536263
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of novel cholic acid derivatives as highly potent agonists for G protein-coupled bile acid receptor.
    Qian M; Luo Z; Hou W; Sun J; Lu X; Zhang Q; Wu Y; Xue C; Zhao S; Chen X
    Bioorg Chem; 2022 Mar; 120():105588. PubMed ID: 34979448
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives.
    Rosatelli E; Carotti A; Cerra B; De Franco F; Passeri D; Pellicciari R; Gioiello A
    Eur J Med Chem; 2023 Dec; 261():115851. PubMed ID: 37813065
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor.
    Abrigo J; Gonzalez F; Aguirre F; Tacchi F; Gonzalez A; Meza MP; Simon F; Cabrera D; Arrese M; Karpen S; Cabello-Verrugio C
    J Cell Physiol; 2021 Jan; 236(1):260-272. PubMed ID: 32506638
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.
    Sato H; Macchiarulo A; Thomas C; Gioiello A; Une M; Hofmann AF; Saladin R; Schoonjans K; Pellicciari R; Auwerx J
    J Med Chem; 2008 Mar; 51(6):1831-41. PubMed ID: 18307294
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy.
    Wang XY; Zhang SY; Li J; Liu HN; Xie X; Nan FJ
    Acta Pharmacol Sin; 2014 Nov; 35(11):1463-72. PubMed ID: 25283506
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular modelling studies on ɑ7 nicotinic receptor allosteric modulators yields novel filter-based virtual screening protocol.
    Al Rawashdah S; Hamrouni A; Sadek B; Amer R; Metwaly M; Atatreh N; Ghattas MA
    J Mol Graph Model; 2019 Nov; 92():44-54. PubMed ID: 31306865
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 7-Methylation of Chenodeoxycholic Acid Derivatives Yields a Substantial Increase in TGR5 Receptor Potency.
    Nakhi A; McDermott CM; Stoltz KL; John K; Hawkinson JE; Ambrose EA; Khoruts A; Sadowsky MJ; Dosa PI
    J Med Chem; 2019 Jul; 62(14):6824-6830. PubMed ID: 31268316
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism.
    Pathak P; Liu H; Boehme S; Xie C; Krausz KW; Gonzalez F; Chiang JYL
    J Biol Chem; 2017 Jun; 292(26):11055-11069. PubMed ID: 28478385
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity.
    Pellicciari R; Gioiello A; Macchiarulo A; Thomas C; Rosatelli E; Natalini B; Sardella R; Pruzanski M; Roda A; Pastorini E; Schoonjans K; Auwerx J
    J Med Chem; 2009 Dec; 52(24):7958-61. PubMed ID: 20014870
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5.
    Macchiarulo A; Gioiello A; Thomas C; Massarotti A; Nuti R; Rosatelli E; Sabbatini P; Schoonjans K; Auwerx J; Pellicciari R
    J Chem Inf Model; 2008 Sep; 48(9):1792-801. PubMed ID: 18698841
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-Activity Relationships of Pan-Gα
    Berizzi AE; Bender AM; Lindsley CW; Conn PJ; Sexton PM; Langmead CJ; Christopoulos A
    ACS Chem Neurosci; 2018 Jul; 9(7):1818-1828. PubMed ID: 29683647
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mutual Cooperativity of Three Allosteric Sites on the Dopamine D1 Receptor.
    Wang X; Hembre EJ; Goldsmith PJ; Beck JP; Svensson KA; Willard FS; Bruns RF
    Mol Pharmacol; 2023 Mar; 103(3):176-187. PubMed ID: 36804203
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of small molecule positive allosteric modulators of the secretin receptor.
    Dengler DG; Harikumar KG; Pollari S; Sun Q; Brown BT; Shinoki-Iwaya A; Ardecky R; Miller LJ; Sergienko EA
    Biochem Pharmacol; 2021 Mar; 185():114451. PubMed ID: 33545115
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects.
    Chaudhari SN; Harris DA; Aliakbarian H; Luo JN; Henke MT; Subramaniam R; Vernon AH; Tavakkoli A; Sheu EG; Devlin AS
    Nat Chem Biol; 2021 Jan; 17(1):20-29. PubMed ID: 32747812
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Quantitative analysis of receptor allosterism and its implication for drug discovery.
    Zhang R; Kavana M
    Expert Opin Drug Discov; 2015 Jul; 10(7):763-80. PubMed ID: 25927503
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.
    Gregory KJ; Noetzel MJ; Rook JM; Vinson PN; Stauffer SR; Rodriguez AL; Emmitte KA; Zhou Y; Chun AC; Felts AS; Chauder BA; Lindsley CW; Niswender CM; Conn PJ
    Mol Pharmacol; 2012 Nov; 82(5):860-75. PubMed ID: 22863693
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of novel pyrimidine and malonamide derivatives as TGR5 agonists.
    Park EJ; Ahn YG; Jung SH; Bang HJ; Kim M; Hong DJ; Kim J; Suh KH; Kim YJ; Kim D; Kim EY; Lee K; Min KH
    Bioorg Med Chem Lett; 2014 Sep; 24(17):4271-5. PubMed ID: 25082126
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Berberine compounds improves hyperglycemia via microbiome mediated colonic TGR5-GLP pathway in db/db mice.
    Li M; Zhou W; Dang Y; Li C; Ji G; Zhang L
    Biomed Pharmacother; 2020 Dec; 132():110953. PubMed ID: 33254441
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Retrospective ensemble docking of allosteric modulators in an adenosine G-protein-coupled receptor.
    Bhattarai A; Wang J; Miao Y
    Biochim Biophys Acta Gen Subj; 2020 Aug; 1864(8):129615. PubMed ID: 32298791
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.