139 related articles for article (PubMed ID: 37596939)
1. Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys.
Mackman RL; Kalla RV; Babusis D; Pitts J; Barrett KT; Chun K; Du Pont V; Rodriguez L; Moshiri J; Xu Y; Lee M; Lee G; Bleier B; Nguyen AQ; O'Keefe BM; Ambrosi A; Cook M; Yu J; Dempah KE; Bunyan E; Riola NC; Lu X; Liu R; Davie A; Hsiang TY; Dearing J; Vermillion M; Gale M; Niedziela-Majka A; Feng JY; Hedskog C; Bilello JP; Subramanian R; Cihlar T
J Med Chem; 2023 Sep; 66(17):11701-11717. PubMed ID: 37596939
[TBL] [Abstract][Full Text] [Related]
2. Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice.
Schäfer A; Martinez DR; Won JJ; Meganck RM; Moreira FR; Brown AJ; Gully KL; Zweigart MR; Conrad WS; May SR; Dong S; Kalla R; Chun K; Du Pont V; Babusis D; Tang J; Murakami E; Subramanian R; Barrett KT; Bleier BJ; Bannister R; Feng JY; Bilello JP; Cihlar T; Mackman RL; Montgomery SA; Baric RS; Sheahan TP
Sci Transl Med; 2022 May; 14(643):eabm3410. PubMed ID: 35315683
[TBL] [Abstract][Full Text] [Related]
3. The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses.
Martinez DR; Moreira FR; Catanzaro NJ; Diefenbacher MV; Zweigart MR; Gully KL; De la Cruz G; Brown AJ; Adams LE; Yount B; Baric TJ; Mallory ML; Conrad H; May SR; Dong S; Scobey DT; Nguyen C; Montgomery SA; Perry JK; Babusis D; Barrett KT; Nguyen AH; Nguyen AQ; Kalla R; Bannister R; Feng JY; Cihlar T; Baric RS; Mackman RL; Bilello JP; Schäfer A; Sheahan TP
Sci Transl Med; 2024 May; 16(748):eadj4504. PubMed ID: 38776389
[TBL] [Abstract][Full Text] [Related]
4. Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection.
Pitts J; Babusis D; Vermillion MS; Subramanian R; Barrett K; Lye D; Ma B; Zhao X; Riola N; Xie X; Kajon A; Lu X; Bannister R; Shi PY; Toteva M; Porter DP; Smith BJ; Cihlar T; Mackman R; Bilello JP
Antiviral Res; 2022 Jul; 203():105329. PubMed ID: 35525335
[TBL] [Abstract][Full Text] [Related]
5. Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets.
Cox RM; Wolf JD; Lieber CM; Sourimant J; Lin MJ; Babusis D; DuPont V; Chan J; Barrett KT; Lye D; Kalla R; Chun K; Mackman RL; Ye C; Cihlar T; Martinez-Sobrido L; Greninger AL; Bilello JP; Plemper RK
Nat Commun; 2021 Nov; 12(1):6415. PubMed ID: 34741049
[TBL] [Abstract][Full Text] [Related]
6. Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2.
Wei D; Hu T; Zhang Y; Zheng W; Xue H; Shen J; Xie Y; Aisa HA
Bioorg Med Chem; 2021 Sep; 46():116364. PubMed ID: 34450570
[TBL] [Abstract][Full Text] [Related]
7. The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants.
Cao L; Li Y; Yang S; Li G; Zhou Q; Sun J; Xu T; Yang Y; Liao R; Shi Y; Yang Y; Zhu T; Huang S; Ji Y; Cong F; Luo Y; Zhu Y; Luan H; Zhang H; Chen J; Liu X; Luo R; Liu L; Wang P; Yu Y; Xing F; Ke B; Zheng H; Deng X; Zhang W; Lin C; Shi M; Li CM; Zhang Y; Zhang L; Dai J; Lu H; Zhao J; Zhang X; Guo D
Sci Transl Med; 2022 Sep; 14(661):eabm7621. PubMed ID: 35579533
[TBL] [Abstract][Full Text] [Related]
8. Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 Activity.
Hu H; Mady Traore MD; Li R; Yuan H; He M; Wen B; Gao W; Jonsson CB; Fitzpatrick EA; Sun D
J Med Chem; 2022 Sep; 65(18):12044-12054. PubMed ID: 36070561
[TBL] [Abstract][Full Text] [Related]
9. AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2
Good SS; Westover J; Jung KH; Zhou XJ; Moussa A; La Colla P; Collu G; Canard B; Sommadossi JP
Antimicrob Agents Chemother; 2021 Mar; 65(4):. PubMed ID: 33558299
[TBL] [Abstract][Full Text] [Related]
10. Broad-Spectrum
Lo MK; Shrivastava-Ranjan P; Chatterjee P; Flint M; Beadle JR; Valiaeva N; Murphy J; Schooley RT; Hostetler KY; Montgomery JM; Spiropoulou CF
Microbiol Spectr; 2021 Dec; 9(3):e0153721. PubMed ID: 34817209
[TBL] [Abstract][Full Text] [Related]
11. Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potential.
Martinez DR; Moreira FR; Zweigart MR; Gully KL; De la Cruz G; Brown AJ; Adams LE; Catanzaro N; Yount B; Baric TJ; Mallory ML; Conrad H; May SR; Dong S; Scobey DT; Montgomery SA; Perry J; Babusis D; Barrett KT; Nguyen AH; Nguyen AQ; Kalla R; Bannister R; Bilello JP; Feng JY; Cihlar T; Baric RS; Mackman RL; Schäfer A; Sheahan TP
bioRxiv; 2023 Jun; ():. PubMed ID: 37425890
[TBL] [Abstract][Full Text] [Related]
12. Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
Mackman RL; Hui HC; Perron M; Murakami E; Palmiotti C; Lee G; Stray K; Zhang L; Goyal B; Chun K; Byun D; Siegel D; Simonovich S; Du Pont V; Pitts J; Babusis D; Vijjapurapu A; Lu X; Kim C; Zhao X; Chan J; Ma B; Lye D; Vandersteen A; Wortman S; Barrett KT; Toteva M; Jordan R; Subramanian R; Bilello JP; Cihlar T
J Med Chem; 2021 Apr; 64(8):5001-5017. PubMed ID: 33835812
[TBL] [Abstract][Full Text] [Related]
13. Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants.
Pitts J; Li J; Perry JK; Du Pont V; Riola N; Rodriguez L; Lu X; Kurhade C; Xie X; Camus G; Manhas S; Martin R; Shi PY; Cihlar T; Porter DP; Mo H; Maiorova E; Bilello JP
Antimicrob Agents Chemother; 2022 Jun; 66(6):e0022222. PubMed ID: 35532238
[TBL] [Abstract][Full Text] [Related]
14. A Review on Remdesivir: A Possible Promising Agent for the Treatment of COVID-19.
Hashemian SM; Farhadi T; Velayati AA
Drug Des Devel Ther; 2020; 14():3215-3222. PubMed ID: 32821086
[TBL] [Abstract][Full Text] [Related]
15. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.
Agostini ML; Andres EL; Sims AC; Graham RL; Sheahan TP; Lu X; Smith EC; Case JB; Feng JY; Jordan R; Ray AS; Cihlar T; Siegel D; Mackman RL; Clarke MO; Baric RS; Denison MR
mBio; 2018 Mar; 9(2):. PubMed ID: 29511076
[TBL] [Abstract][Full Text] [Related]
16. Advancement of Prodrug Approaches for Nucleotide Antiviral Agents.
Li Y; Yang B; Quan Y; Li Z
Curr Top Med Chem; 2021; 21(32):2909-2927. PubMed ID: 34323189
[TBL] [Abstract][Full Text] [Related]
17. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.
Warren TK; Jordan R; Lo MK; Ray AS; Mackman RL; Soloveva V; Siegel D; Perron M; Bannister R; Hui HC; Larson N; Strickley R; Wells J; Stuthman KS; Van Tongeren SA; Garza NL; Donnelly G; Shurtleff AC; Retterer CJ; Gharaibeh D; Zamani R; Kenny T; Eaton BP; Grimes E; Welch LS; Gomba L; Wilhelmsen CL; Nichols DK; Nuss JE; Nagle ER; Kugelman JR; Palacios G; Doerffler E; Neville S; Carra E; Clarke MO; Zhang L; Lew W; Ross B; Wang Q; Chun K; Wolfe L; Babusis D; Park Y; Stray KM; Trancheva I; Feng JY; Barauskas O; Xu Y; Wong P; Braun MR; Flint M; McMullan LK; Chen SS; Fearns R; Swaminathan S; Mayers DL; Spiropoulou CF; Lee WA; Nichol ST; Cihlar T; Bavari S
Nature; 2016 Mar; 531(7594):381-5. PubMed ID: 26934220
[TBL] [Abstract][Full Text] [Related]
18. Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs.
Schooley RT; Carlin AF; Beadle JR; Valiaeva N; Zhang XQ; Clark AE; McMillan RE; Leibel SL; McVicar RN; Xie J; Garretson AF; Smith VI; Murphy J; Hostetler KY
Antimicrob Agents Chemother; 2021 Sep; 65(10):e0115521. PubMed ID: 34310217
[TBL] [Abstract][Full Text] [Related]
19. In vitro activity of itraconazole against SARS-CoV-2.
Van Damme E; De Meyer S; Bojkova D; Ciesek S; Cinatl J; De Jonghe S; Jochmans D; Leyssen P; Buyck C; Neyts J; Van Loock M
J Med Virol; 2021 Jul; 93(7):4454-4460. PubMed ID: 33666253
[TBL] [Abstract][Full Text] [Related]
20. Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.
Schäfer A; Martinez DR; Won JJ; Moreira FR; Brown AJ; Gully KL; Kalla R; Chun K; Du Pont V; Babusis D; Tang J; Murakami E; Subramanian R; Barrett KT; Bleier BJ; Bannister R; Feng JY; Bilello JP; Cihlar T; Mackman RL; Montgomery SA; Baric RS; Sheahan TP
bioRxiv; 2021 Sep; ():. PubMed ID: 34545367
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]