BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

190 related articles for article (PubMed ID: 37605285)

  • 1. APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids.
    Zhao J; Ikezu TC; Lu W; Macyczko JR; Li Y; Lewis-Tuffin LJ; Martens YA; Ren Y; Zhu Y; Asmann YW; Ertekin-Taner N; Kanekiyo T; Bu G
    Stem Cell Res Ther; 2023 Aug; 14(1):214. PubMed ID: 37605285
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Culture Variabilities of Human iPSC-Derived Cerebral Organoids Are a Major Issue for the Modelling of Phenotypes Observed in Alzheimer's Disease.
    Hernández D; Rooney LA; Daniszewski M; Gulluyan L; Liang HH; Cook AL; Hewitt AW; Pébay A
    Stem Cell Rev Rep; 2022 Feb; 18(2):718-731. PubMed ID: 33725267
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids.
    Zhao J; Lu W; Ren Y; Fu Y; Martens YA; Shue F; Davis MD; Wang X; Chen K; Li F; Liu CC; Graff-Radford NR; Wszolek ZK; Younkin SG; Brafman DA; Ertekin-Taner N; Asmann YW; Dickson DW; Xu Z; Pan M; Han X; Kanekiyo T; Bu G
    Acta Neuropathol; 2021 Nov; 142(5):807-825. PubMed ID: 34453582
    [TBL] [Abstract][Full Text] [Related]  

  • 4. APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes.
    de Leeuw SM; Kirschner AWT; Lindner K; Rust R; Budny V; Wolski WE; Gavin AC; Nitsch RM; Tackenberg C
    Stem Cell Reports; 2022 Jan; 17(1):110-126. PubMed ID: 34919811
    [TBL] [Abstract][Full Text] [Related]  

  • 5. APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.
    Lin YT; Seo J; Gao F; Feldman HM; Wen HL; Penney J; Cam HP; Gjoneska E; Raja WK; Cheng J; Rueda R; Kritskiy O; Abdurrob F; Peng Z; Milo B; Yu CJ; Elmsaouri S; Dey D; Ko T; Yankner BA; Tsai LH
    Neuron; 2018 Jun; 98(6):1141-1154.e7. PubMed ID: 29861287
    [TBL] [Abstract][Full Text] [Related]  

  • 6. APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.
    Zhao J; Fu Y; Yamazaki Y; Ren Y; Davis MD; Liu CC; Lu W; Wang X; Chen K; Cherukuri Y; Jia L; Martens YA; Job L; Shue F; Nguyen TT; Younkin SG; Graff-Radford NR; Wszolek ZK; Brafman DA; Asmann YW; Ertekin-Taner N; Kanekiyo T; Bu G
    Nat Commun; 2020 Nov; 11(1):5540. PubMed ID: 33139712
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.
    Tcw J; Qian L; Pipalia NH; Chao MJ; Liang SA; Shi Y; Jain BR; Bertelsen SE; Kapoor M; Marcora E; Sikora E; Andrews EJ; Martini AC; Karch CM; Head E; Holtzman DM; Zhang B; Wang M; Maxfield FR; Poon WW; Goate AM
    Cell; 2022 Jun; 185(13):2213-2233.e25. PubMed ID: 35750033
    [TBL] [Abstract][Full Text] [Related]  

  • 8. APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes.
    Zhao J; Davis MD; Martens YA; Shinohara M; Graff-Radford NR; Younkin SG; Wszolek ZK; Kanekiyo T; Bu G
    Hum Mol Genet; 2017 Jul; 26(14):2690-2700. PubMed ID: 28444230
    [TBL] [Abstract][Full Text] [Related]  

  • 9.
    Sienski G; Narayan P; Bonner JM; Kory N; Boland S; Arczewska AA; Ralvenius WT; Akay L; Lockshin E; He L; Milo B; Graziosi A; Baru V; Lewis CA; Kellis M; Sabatini DM; Tsai LH; Lindquist S
    Sci Transl Med; 2021 Mar; 13(583):. PubMed ID: 33658354
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Generation and validation of
    Martens YA; Xu S; Tait R; Li G; Zhao XC; Lu W; Liu CC; Kanekiyo T; Bu G; Zhao J
    STAR Protoc; 2021 Jun; 2(2):100571. PubMed ID: 34151296
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk.
    Huang YA; Zhou B; Nabet AM; Wernig M; Südhof TC
    J Neurosci; 2019 Sep; 39(37):7408-7427. PubMed ID: 31331998
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Plasma ApoE4 Levels Are Lower than ApoE2 and ApoE3 Levels, and Not Associated with Plasma Aβ40/42 Ratio as a Biomarker of Amyloid-β Amyloidosis in Alzheimer's Disease.
    Nakamura T; Kawarabayashi T; Ueda T; Shimomura S; Hoshino M; Itoh K; Ihara K; Nakaji S; Takatama M; Ikeda Y; Shoji M
    J Alzheimers Dis; 2023; 93(1):333-348. PubMed ID: 36970894
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice.
    Gong JS; Kobayashi M; Hayashi H; Zou K; Sawamura N; Fujita SC; Yanagisawa K; Michikawa M
    J Biol Chem; 2002 Aug; 277(33):29919-26. PubMed ID: 12042316
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer's disease (AD) risk.
    Raman S; Brookhouser N; Brafman DA
    Neurobiol Dis; 2020 May; 138():104788. PubMed ID: 32032733
    [TBL] [Abstract][Full Text] [Related]  

  • 15. ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes.
    Lee H; Cho S; Kim MJ; Park YJ; Cho E; Jo YS; Kim YS; Lee JY; Thoudam T; Woo SH; Lee SI; Jeon J; Lee YS; Suh BC; Yoon JH; Go Y; Lee IK; Seo J
    Cell Rep; 2023 Oct; 42(10):113183. PubMed ID: 37777962
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice.
    Hu J; Liu CC; Chen XF; Zhang YW; Xu H; Bu G
    Mol Neurodegener; 2015 Mar; 10():6. PubMed ID: 25871773
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels.
    Jansen PJ; Lütjohann D; Thelen KM; von Bergmann K; van Leuven F; Ramaekers FC; Monique M
    J Alzheimers Dis; 2009; 18(2):319-29. PubMed ID: 19584433
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Transcriptomic Mapping of Neural Diversity, Differentiation and Functional Trajectory in iPSC-Derived 3D Brain Organoid Models.
    Kiaee K; Jodat YA; Bassous NJ; Matharu N; Shin SR
    Cells; 2021 Dec; 10(12):. PubMed ID: 34943930
    [TBL] [Abstract][Full Text] [Related]  

  • 19. APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis.
    Ramakrishna S; Jhaveri V; Konings SC; Nawalpuri B; Chakraborty S; Holst B; Schmid B; Gouras GK; Freude KK; Muddashetty RS
    J Neurosci; 2021 Oct; 41(42):8686-8709. PubMed ID: 34475200
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
    Brecht WJ; Harris FM; Chang S; Tesseur I; Yu GQ; Xu Q; Dee Fish J; Wyss-Coray T; Buttini M; Mucke L; Mahley RW; Huang Y
    J Neurosci; 2004 Mar; 24(10):2527-34. PubMed ID: 15014128
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.