149 related articles for article (PubMed ID: 37605297)
21. Akebia saponin E, as a novel PIKfyve inhibitor, induces lysosome-associated cytoplasmic vacuolation to inhibit proliferation of hepatocellular carcinoma cells.
Peng P; Jia D; Cao L; Lu W; Liu X; Liang C; Pan Z; Fang Z
J Ethnopharmacol; 2021 Feb; 266():113446. PubMed ID: 33031902
[TBL] [Abstract][Full Text] [Related]
22. Discovery of
Liu L; Zhao L; Yang L; Chai M; Liu Z; Ma N; Wang Y; Wu Q; Guo J; Zhou F; Huang W; Ren X; Wang J; Ding M; Wang Z; Ding K
J Med Chem; 2024 May; 67(10):8043-8059. PubMed ID: 38730324
[TBL] [Abstract][Full Text] [Related]
23. PIKFYVE inhibitors trigger interleukin-24-dependent cell death of autophagy-dependent melanoma.
Roy A; Chakraborty AR; DePamphilis ML
Mol Oncol; 2024 Apr; 18(4):988-1011. PubMed ID: 38414326
[TBL] [Abstract][Full Text] [Related]
24. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands.
Han X; Zhao L; Xiang W; Qin C; Miao B; Xu T; Wang M; Yang CY; Chinnaswamy K; Stuckey J; Wang S
J Med Chem; 2019 Dec; 62(24):11218-11231. PubMed ID: 31804827
[TBL] [Abstract][Full Text] [Related]
25. Discovery of A031 as effective proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader for the treatment of prostate cancer.
Chen L; Han L; Mao S; Xu P; Xu X; Zhao R; Wu Z; Zhong K; Yu G; Wang X
Eur J Med Chem; 2021 Apr; 216():113307. PubMed ID: 33652354
[TBL] [Abstract][Full Text] [Related]
26. Discovery of Highly Potent Nicotinamide Phosphoribosyltransferase Degraders for Efficient Treatment of Ovarian Cancer.
Bi K; Cheng J; He S; Fang Y; Huang M; Sheng C; Dong G
J Med Chem; 2023 Jan; 66(1):1048-1062. PubMed ID: 36563407
[TBL] [Abstract][Full Text] [Related]
27. Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader.
Carmona AV; Jonnalagadda S; Case AM; Maddeboina K; Jonnalagadda SK; Dow LF; Duan L; Penning TM; Trippier PC
Commun Chem; 2024 Apr; 7(1):95. PubMed ID: 38684887
[TBL] [Abstract][Full Text] [Related]
28. Potent and Selective Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2) Heterobifunctional Small-molecule Degraders.
Hu J; Wei J; Yim H; Wang L; Xie L; Jin MS; Kabir M; Qin L; Chen X; Liu J; Jin J
J Med Chem; 2020 Dec; 63(24):15883-15905. PubMed ID: 33284613
[TBL] [Abstract][Full Text] [Related]
29. Discovery of the First Potent, Selective, and
Sun Y; Xue Y; Sun P; Mu S; Liu H; Sun Y; Wang L; Wang J; Wu T; Yin W; Qin Q; Sun Y; Liu N; Wang H; Yang H; Zhao D; Cheng M
J Med Chem; 2023 Jun; 66(12):8200-8221. PubMed ID: 37279162
[TBL] [Abstract][Full Text] [Related]
30. Discovery of novel potent covalent inhibitor-based EGFR degrader with excellent in vivo efficacy.
Shi S; Du Y; Huang L; Cui J; Niu J; Xu Y; Zhu Q
Bioorg Chem; 2022 Mar; 120():105605. PubMed ID: 35081479
[TBL] [Abstract][Full Text] [Related]
31. PIKfyve controls dendritic cell function and tumor immunity.
Choi JE; Qiao Y; Kryczek I; Yu J; Gurkan J; Bao Y; Gondal M; Tien JC; Maj T; Yazdani S; Parolia A; Xia H; Zhou J; Wei S; Grove S; Vatan L; Lin H; Li G; Zheng Y; Zhang Y; Cao X; Su F; Wang R; He T; Cieslik M; Green MD; Zou W; Chinnaiyan AM
bioRxiv; 2024 Mar; ():. PubMed ID: 38464258
[TBL] [Abstract][Full Text] [Related]
32. Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition.
Sano O; Kazetani K; Funata M; Fukuda Y; Matsui J; Iwata H
FEBS Lett; 2016 Jun; 590(11):1576-85. PubMed ID: 27135648
[TBL] [Abstract][Full Text] [Related]
33. Blocked autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363.
Lamoureux F; Thomas C; Crafter C; Kumano M; Zhang F; Davies BR; Gleave ME; Zoubeidi A
Clin Cancer Res; 2013 Feb; 19(4):833-44. PubMed ID: 23258740
[TBL] [Abstract][Full Text] [Related]
34. Discovery of the First-in-Class G9a/GLP PROTAC Degrader.
Velez J; Han Y; Yim H; Yang P; Deng Z; Park KS; Kabir M; Kaniskan HÜ; Xiong Y; Jin J
J Med Chem; 2024 Apr; 67(8):6397-6409. PubMed ID: 38602846
[TBL] [Abstract][Full Text] [Related]
35. Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer.
Cheng C; Hu J; Mannan R; Bhattacharyya R; Rossiter NJ; Magnuson B; Wisniewski JP; Zheng Y; Xiao L; Li C; Awad D; He T; Bao Y; Zhang Y; Cao X; Wang Z; Mehra R; Morlacchi P; Sahai V; di Magliano MP; Shah YM; Ding K; Qiao Y; Lyssiotis CA; Chinnaiyan AM
bioRxiv; 2024 Mar; ():. PubMed ID: 38562800
[TBL] [Abstract][Full Text] [Related]
36. Discovery of the First-in-class G9a/GLP PROTAC Degrader.
Velez J; Han Y; Yim H; Yang P; Deng Z; Park KS; Kabir M; Kaniskan HÜ; Xiong Y; Jin J
bioRxiv; 2024 Feb; ():. PubMed ID: 38464025
[TBL] [Abstract][Full Text] [Related]
37. PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1.
Oppelt A; Haugsten EM; Zech T; Danielsen HE; Sveen A; Lobert VH; Skotheim RI; Wesche J
Biochem J; 2014 Aug; 461(3):383-90. PubMed ID: 24840251
[TBL] [Abstract][Full Text] [Related]
38. Discovery of highly potent and selective KRAS
Yang N; Fan Z; Sun S; Hu X; Mao Y; Jia C; Cai X; Xu T; Li B; Li Y; Han L; Wei T; Qian X; Qin W; Li P; Zheng Z; Li S
Eur J Med Chem; 2023 Dec; 261():115857. PubMed ID: 37852032
[TBL] [Abstract][Full Text] [Related]
39. Discovery of CBPD-409 as a Highly Potent, Selective, and Orally Efficacious CBP/p300 PROTAC Degrader for the Treatment of Advanced Prostate Cancer.
Chen Z; Wang M; Wu D; Zhao L; Metwally H; Jiang W; Wang Y; Bai L; McEachern D; Luo J; Wang M; Li Q; Matvekas A; Wen B; Sun D; Chinnaiyan AM; Wang S
J Med Chem; 2024 Apr; 67(7):5351-5372. PubMed ID: 38530938
[TBL] [Abstract][Full Text] [Related]
40. PIKfyve regulation of endosome-linked pathways.
de Lartigue J; Polson H; Feldman M; Shokat K; Tooze SA; Urbé S; Clague MJ
Traffic; 2009 Jul; 10(7):883-93. PubMed ID: 19582903
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
