These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

214 related articles for article (PubMed ID: 37665033)

  • 1. Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.
    Syed A; Filandr F; Patterson-Fortin J; Bacolla A; Ravindranathan R; Zhou J; McDonald DT; Albuhluli ME; Verway-Cohen A; Newman JA; Tsai MS; Jones DE; Schriemer DC; D'Andrea AD; Tainer JA
    Nucleic Acids Res; 2023 Oct; 51(18):9920-9937. PubMed ID: 37665033
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.
    Zhou J; Gelot C; Pantelidou C; Li A; Yücel H; Davis RE; Färkkilä A; Kochupurakkal B; Syed A; Shapiro GI; Tainer JA; Blagg BSJ; Ceccaldi R; D'Andrea AD
    Nat Cancer; 2021 Jun; 2(6):598-610. PubMed ID: 34179826
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Polymerase theta is a synthetic lethal target for killing Epstein-Barr virus lymphomas.
    Willman GH; Xu H; Zeigler TM; McIntosh MT; Bhaduri-McIntosh S
    J Virol; 2024 Jul; 98(7):e0057224. PubMed ID: 38860782
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM.
    Ito F; Li Z; Minakhin L; Chandramouly G; Tyagi M; Betsch R; Krais JJ; Taberi B; Vekariya U; Calbert M; Skorski T; Johnson N; Chen XS; Pomerantz RT
    Nat Commun; 2024 Aug; 15(1):7003. PubMed ID: 39143110
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.
    Ceccaldi R; Liu JC; Amunugama R; Hajdu I; Primack B; Petalcorin MI; O'Connor KW; Konstantinopoulos PA; Elledge SJ; Boulton SJ; Yusufzai T; D'Andrea AD
    Nature; 2015 Feb; 518(7538):258-62. PubMed ID: 25642963
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours.
    Barszczewska-Pietraszek G; Drzewiecka M; Czarny P; Skorski T; Śliwiński T
    Int J Mol Sci; 2022 Dec; 24(1):. PubMed ID: 36613762
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.
    Zatreanu D; Robinson HMR; Alkhatib O; Boursier M; Finch H; Geo L; Grande D; Grinkevich V; Heald RA; Langdon S; Majithiya J; McWhirter C; Martin NMB; Moore S; Neves J; Rajendra E; Ranzani M; Schaedler T; Stockley M; Wiggins K; Brough R; Sridhar S; Gulati A; Shao N; Badder LM; Novo D; Knight EG; Marlow R; Haider S; Callen E; Hewitt G; Schimmel J; Prevo R; Alli C; Ferdinand A; Bell C; Blencowe P; Bot C; Calder M; Charles M; Curry J; Ekwuru T; Ewings K; Krajewski W; MacDonald E; McCarron H; Pang L; Pedder C; Rigoreau L; Swarbrick M; Wheatley E; Willis S; Wong AC; Nussenzweig A; Tijsterman M; Tutt A; Boulton SJ; Higgins GS; Pettitt SJ; Smith GCM; Lord CJ
    Nat Commun; 2021 Jun; 12(1):3636. PubMed ID: 34140467
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Polymerase θ-helicase efficiently unwinds DNA and RNA-DNA hybrids.
    Ozdemir AY; Rusanov T; Kent T; Siddique LA; Pomerantz RT
    J Biol Chem; 2018 Apr; 293(14):5259-5269. PubMed ID: 29444826
    [No Abstract]   [Full Text] [Related]  

  • 9. POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells.
    Schrempf A; Bernardo S; Arasa Verge EA; Ramirez Otero MA; Wilson J; Kirchhofer D; Timelthaler G; Ambros AM; Kaya A; Wieder M; Ecker GF; Winter GE; Costanzo V; Loizou JI
    Cell Rep; 2022 Nov; 41(9):111716. PubMed ID: 36400033
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanisms of synthetic lethality between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta targeting.
    Ronson GE; Starowicz K; Anthony EJ; Piberger AL; Clarke LC; Garvin AJ; Beggs AD; Whalley CM; Edmonds MJ; Beesley JFJ; Morris JR
    Nat Commun; 2023 Nov; 14(1):7834. PubMed ID: 38030626
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Targeting DNA Repair with Combined Inhibition of NHEJ and MMEJ Induces Synthetic Lethality in TP53-Mutant Cancers.
    Patterson-Fortin J; Bose A; Tsai WC; Grochala C; Nguyen H; Zhou J; Parmar K; Lazaro JB; Liu J; McQueen K; Shapiro GI; Kozono D; D'Andrea AD
    Cancer Res; 2022 Oct; 82(20):3815-3829. PubMed ID: 35972384
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Targeting Polymerase Theta (POLθ) for Cancer Therapy.
    Patterson-Fortin J; D'Andrea AD
    Cancer Treat Res; 2023; 186():285-298. PubMed ID: 37978141
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular basis of microhomology-mediated end-joining by purified full-length Polθ.
    Black SJ; Ozdemir AY; Kashkina E; Kent T; Rusanov T; Ristic D; Shin Y; Suma A; Hoang T; Chandramouly G; Siddique LA; Borisonnik N; Sullivan-Reed K; Mallon JS; Skorski T; Carnevale V; Murakami KS; Wyman C; Pomerantz RT
    Nat Commun; 2019 Sep; 10(1):4423. PubMed ID: 31562312
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Sequential requirements for distinct Polθ domains during theta-mediated end joining.
    Fijen C; Drogalis Beckham L; Terino D; Li Y; Ramsden DA; Wood RD; Doublié S; Rothenberg E
    Mol Cell; 2024 Apr; 84(8):1460-1474.e6. PubMed ID: 38640894
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of
    Bubenik M; Mader P; Mochirian P; Vallée F; Clark J; Truchon JF; Perryman AL; Pau V; Kurinov I; Zahn KE; Leclaire ME; Papp R; Mathieu MC; Hamel M; Duffy NM; Godbout C; Casas-Selves M; Falgueyret JP; Baruah PS; Nicolas O; Stocco R; Poirier H; Martino G; Fortin AB; Roulston A; Chefson A; Dorich S; St-Onge M; Patel P; Pellerin C; Ciblat S; Pinter T; Barabé F; El Bakkouri M; Parikh P; Gervais C; Sfeir A; Mamane Y; Morris SJ; Black WC; Sicheri F; Gallant M
    J Med Chem; 2022 Oct; 65(19):13198-13215. PubMed ID: 36126059
    [TBL] [Abstract][Full Text] [Related]  

  • 16. POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps.
    Mann A; Ramirez-Otero MA; De Antoni A; Hanthi YW; Sannino V; Baldi G; Falbo L; Schrempf A; Bernardo S; Loizou J; Costanzo V
    Mol Cell; 2022 Nov; 82(22):4218-4231.e8. PubMed ID: 36400008
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Polymerase θ Coordinates Multiple Intrinsic Enzymatic Activities during DNA Repair.
    Zahn KE; Jensen RB
    Genes (Basel); 2021 Aug; 12(9):. PubMed ID: 34573292
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Small Molecules Targeting DNA Polymerase Theta (POLθ) as Promising Synthetic Lethal Agents for Precision Cancer Therapy.
    Pismataro MC; Astolfi A; Barreca ML; Pacetti M; Schenone S; Bandiera T; Carbone A; Massari S
    J Med Chem; 2023 May; 66(10):6498-6522. PubMed ID: 37134182
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis.
    Gelot C; Kovacs MT; Miron S; Mylne E; Haan A; Boeffard-Dosierre L; Ghouil R; Popova T; Dingli F; Loew D; Guirouilh-Barbat J; Del Nery E; Zinn-Justin S; Ceccaldi R
    Nature; 2023 Sep; 621(7978):415-422. PubMed ID: 37674080
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi.
    de Lima LP; Calderano SG; da Silva MS; de Araujo CB; Vasconcelos EJR; Iwai LK; Pereira CA; Fragoso SP; Elias MC
    Sci Rep; 2019 Feb; 9(1):2888. PubMed ID: 30814563
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.