BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

164 related articles for article (PubMed ID: 37823551)

  • 1. Mutant SF3B1 promotes malignancy in PDAC.
    Simmler P; Ioannidi EI; Mengis T; Marquart KF; Asawa S; Van-Lehmann K; Kahles A; Thomas T; Schwerdel C; Aceto N; Rätsch G; Stoffel M; Schwank G
    Elife; 2023 Oct; 12():. PubMed ID: 37823551
    [TBL] [Abstract][Full Text] [Related]  

  • 2. SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A-c-Myc axis.
    Yang JY; Huo YM; Yang MW; Shen Y; Liu DJ; Fu XL; Tao LY; He RZ; Zhang JF; Hua R; Jiang SH; Sun YW; Liu W
    Mol Oncol; 2021 Nov; 15(11):3076-3090. PubMed ID: 33932092
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1.
    Genrich G; Kruppa M; Lenk L; Helm O; Broich A; Freitag-Wolf S; Röcken C; Sipos B; Schäfer H; Sebens S
    BMC Cancer; 2016 Feb; 16():155. PubMed ID: 26915435
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug.
    Alors-Perez E; Blázquez-Encinas R; Alcalá S; Viyuela-García C; Pedraza-Arevalo S; Herrero-Aguayo V; Jiménez-Vacas JM; Mafficini A; Sánchez-Frías ME; Cano MT; Abollo-Jiménez F; Marín-Sanz JA; Cabezas-Sainz P; Lawlor RT; Luchini C; Sánchez L; Sánchez-Hidalgo JM; Ventura S; Martin-Hijano L; Gahete MD; Scarpa A; Arjona-Sánchez Á; Ibáñez-Costa A; Sainz B; Luque RM; Castaño JP
    J Exp Clin Cancer Res; 2021 Dec; 40(1):382. PubMed ID: 34857016
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling.
    Ungefroren H; Sebens S; Giehl K; Helm O; Groth S; Fändrich F; Röcken C; Sipos B; Lehnert H; Gieseler F
    Oncotarget; 2014 Jan; 5(1):277-90. PubMed ID: 24378395
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancer.
    Geismann C; Morscheck M; Koch D; Bergmann F; Ungefroren H; Arlt A; Tsao MS; Bachem MG; Altevogt P; Sipos B; Fölsch UR; Schäfer H; Müerköster SS
    Cancer Res; 2009 May; 69(10):4517-26. PubMed ID: 19435915
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Stem cell marker nestin is critical for TGF-β1-mediated tumor progression in pancreatic cancer.
    Su HT; Weng CC; Hsiao PJ; Chen LH; Kuo TL; Chen YW; Kuo KK; Cheng KH
    Mol Cancer Res; 2013 Jul; 11(7):768-79. PubMed ID: 23552743
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Simvastatin attenuates macrophage-mediated gemcitabine resistance of pancreatic ductal adenocarcinoma by regulating the TGF-β1/Gfi-1 axis.
    Xian G; Zhao J; Qin C; Zhang Z; Lin Y; Su Z
    Cancer Lett; 2017 Jan; 385():65-74. PubMed ID: 27840243
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma.
    Zhang W; Nandakumar N; Shi Y; Manzano M; Smith A; Graham G; Gupta S; Vietsch EE; Laughlin SZ; Wadhwa M; Chetram M; Joshi M; Wang F; Kallakury B; Toretsky J; Wellstein A; Yi C
    Sci Signal; 2014 May; 7(324):ra42. PubMed ID: 24803537
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression.
    Ijichi H; Chytil A; Gorska AE; Aakre ME; Fujitani Y; Fujitani S; Wright CV; Moses HL
    Genes Dev; 2006 Nov; 20(22):3147-60. PubMed ID: 17114585
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Binding of the transcription factor Slug to the L1CAM promoter is essential for transforming growth factor-β1 (TGF-β)-induced L1CAM expression in human pancreatic ductal adenocarcinoma cells.
    Geismann C; Arlt A; Bauer I; Pfeifer M; Schirmer U; Altevogt P; Müerköster SS; Schäfer H
    Int J Oncol; 2011 Jan; 38(1):257-66. PubMed ID: 21109948
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation.
    Obeng EA; Chappell RJ; Seiler M; Chen MC; Campagna DR; Schmidt PJ; Schneider RK; Lord AM; Wang L; Gambe RG; McConkey ME; Ali AM; Raza A; Yu L; Buonamici S; Smith PG; Mullally A; Wu CJ; Fleming MD; Ebert BL
    Cancer Cell; 2016 Sep; 30(3):404-417. PubMed ID: 27622333
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Characterization of the aberrant splicing of MAP3K7 induced by cancer-associated SF3B1 mutation.
    Li Z; Zhao B; Shi Y; Liang Y; Qian R; Wan Y
    J Biochem; 2021 Sep; 170(1):69-77. PubMed ID: 33751071
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Crosstalk between Nrf2 and TGF-β1 in the Epithelial-Mesenchymal Transition of Pancreatic Duct Epithelial Cells.
    Arfmann-Knübel S; Struck B; Genrich G; Helm O; Sipos B; Sebens S; Schäfer H
    PLoS One; 2015; 10(7):e0132978. PubMed ID: 26226105
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The antioxidant transcription factor Nrf2 modulates the stress response and phenotype of malignant as well as premalignant pancreatic ductal epithelial cells by inducing expression of the ATF3 splicing variant ΔZip2.
    Kha ML; Hesse L; Deisinger F; Sipos B; Röcken C; Arlt A; Sebens S; Helm O; Schäfer H
    Oncogene; 2019 Feb; 38(9):1461-1476. PubMed ID: 30302023
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Role of TGF-β in pancreatic ductal adenocarcinoma progression and PD-L1 expression.
    Hussain SM; Kansal RG; Alvarez MA; Hollingsworth TJ; Elahi A; Miranda-Carboni G; Hendrick LE; Pingili AK; Albritton LM; Dickson PV; Deneve JL; Yakoub D; Hayes DN; Kurosu M; Shibata D; Makowski L; Glazer ES
    Cell Oncol (Dordr); 2021 Jun; 44(3):673-687. PubMed ID: 33694102
    [TBL] [Abstract][Full Text] [Related]  

  • 17. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.
    Nolan-Stevaux O; Lau J; Truitt ML; Chu GC; Hebrok M; Fernández-Zapico ME; Hanahan D
    Genes Dev; 2009 Jan; 23(1):24-36. PubMed ID: 19136624
    [TBL] [Abstract][Full Text] [Related]  

  • 18. SMAD4 endows TGF-β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer.
    Chen HD; Ye Z; Hu HF; Fan GX; Hu YH; Li Z; Li BR; Ji SR; Zhou CJ; Xu XW; Yu XJ; Qin Y
    Acta Pharmacol Sin; 2024 Apr; 45(4):844-856. PubMed ID: 38057506
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.
    Bardeesy N; Cheng KH; Berger JH; Chu GC; Pahler J; Olson P; Hezel AF; Horner J; Lauwers GY; Hanahan D; DePinho RA
    Genes Dev; 2006 Nov; 20(22):3130-46. PubMed ID: 17114584
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Oncogenic ERBB2 aberrations and KRAS mutations cooperate to promote pancreatic ductal adenocarcinoma progression.
    Li Z; Shao C; Liu X; Lu X; Jia X; Zheng X; Wang S; Zhu L; Li K; Pang Y; Xie F; Lu Y; Wang Y
    Carcinogenesis; 2020 Mar; 41(1):44-55. PubMed ID: 31046123
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.