BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

214 related articles for article (PubMed ID: 37875111)

  • 1. Methotrexate-based PROTACs as DHFR-specific chemical probes.
    Rana S; Dranchak P; Dahlin JL; Lamy L; Li W; Oliphant E; Shrimp JH; Rajacharya GH; Tharakan R; Holland DO; Whitten AS; Wilson KM; Singh PK; Durum SK; Tao D; Rai G; Inglese J
    Cell Chem Biol; 2024 Feb; 31(2):221-233.e14. PubMed ID: 37875111
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular mechanisms of resistance to antifolates, a review.
    Banerjee D; Ercikan-Abali E; Waltham M; Schnieders B; Hochhauser D; Li WW; Fan J; Gorlick R; Goker E; Bertino JR
    Acta Biochim Pol; 1995; 42(4):457-64. PubMed ID: 8852336
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
    Chen G; Wright JE; Rosowsky A
    Mol Pharmacol; 1995 Oct; 48(4):758-65. PubMed ID: 7476904
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Anticancer antifolates: current status and future directions.
    McGuire JJ
    Curr Pharm Des; 2003; 9(31):2593-613. PubMed ID: 14529544
    [TBL] [Abstract][Full Text] [Related]  

  • 5. In Silico Study Identified Methotrexate Analog as Potential Inhibitor of Drug Resistant Human Dihydrofolate Reductase for Cancer Therapeutics.
    Rana RM; Rampogu S; Abid NB; Zeb A; Parate S; Lee G; Yoon S; Kim Y; Kim D; Lee KW
    Molecules; 2020 Jul; 25(15):. PubMed ID: 32752079
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Much more than you expected: The non-DHFR-mediated effects of methotrexate.
    Sramek M; Neradil J; Veselska R
    Biochim Biophys Acta Gen Subj; 2017 Mar; 1861(3):499-503. PubMed ID: 27993660
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Diddens H; Niethammer D; Jackson RC
    Cancer Res; 1983 Nov; 43(11):5286-92. PubMed ID: 6225514
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase.
    Banerjee D; Mayer-Kuckuk P; Capiaux G; Budak-Alpdogan T; Gorlick R; Bertino JR
    Biochim Biophys Acta; 2002 Jul; 1587(2-3):164-73. PubMed ID: 12084458
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum.
    Bhattacharya A; Leprohon P; Ouellette M
    PLoS Negl Trop Dis; 2021 Apr; 15(4):e0009377. PubMed ID: 33905412
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel 6,5-fused ring heterocyclic antifolates: biochemical and biological characterization.
    McGuire JJ; Bergoltz VV; Heitzman KJ; Haile WH; Russell CA; Bolanowska WE; Kotake Y; Haneda T; Nomura H
    Cancer Res; 1994 May; 54(10):2673-9. PubMed ID: 8168096
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
    Rhee MS; Galivan J; Wright JE; Rosowsky A
    Mol Pharmacol; 1994 Apr; 45(4):783-91. PubMed ID: 7514264
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.
    Senkovich O; Schormann N; Chattopadhyay D
    Acta Crystallogr D Biol Crystallogr; 2009 Jul; 65(Pt 7):704-16. PubMed ID: 19564691
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dihydrofolate Reductase and Thymidylate Synthase Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation.
    Rushworth D; Mathews A; Alpert A; Cooper LJ
    J Biol Chem; 2015 Sep; 290(38):22970-6. PubMed ID: 26242737
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cancer research: from folate antagonism to molecular targets.
    Bertino JR
    Best Pract Res Clin Haematol; 2009 Dec; 22(4):577-82. PubMed ID: 19959110
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates.
    Goldman ID; Matherly LH
    NCI Monogr; 1987; (5):17-26. PubMed ID: 2448654
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Drug-resistant dihydrofolate reductases: generation, expression and therapeutic application.
    McIvor RS
    Bone Marrow Transplant; 1996 Dec; 18 Suppl 3():S50-4. PubMed ID: 8971409
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I.
    Gangjee A; Jain HD; Kurup S
    Anticancer Agents Med Chem; 2007 Sep; 7(5):524-42. PubMed ID: 17896913
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Role of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae.
    Kündig C; Leblanc E; Papadopoulou B; Ouellette M
    Nucleic Acids Res; 1999 Sep; 27(18):3653-9. PubMed ID: 10471733
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.
    Gangjee A; Yu J; McGuire JJ; Cody V; Galitsky N; Kisliuk RL; Queener SF
    J Med Chem; 2000 Oct; 43(21):3837-51. PubMed ID: 11052789
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A molecular model of the folate binding site of Pneumocystis carinii dihydrofolate reductase.
    Southerland WM
    J Comput Aided Mol Des; 1994 Apr; 8(2):113-22. PubMed ID: 8064329
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.