177 related articles for article (PubMed ID: 37895825)
1. Structure-Activity Relationship Studies of Chalcones and Diarylpentanoids with Antitumor Activity: Potency and Selectivity Optimization.
Moreira J; Loureiro JB; Correia D; Palmeira A; Pinto MM; Saraiva L; Cidade H
Pharmaceuticals (Basel); 2023 Sep; 16(10):. PubMed ID: 37895825
[TBL] [Abstract][Full Text] [Related]
2. Discovery of a New Chalcone-Trimethoxycinnamide Hybrid with Antimitotic Effect: Design, Synthesis, and Structure-Activity Relationship Studies.
Moreira J; Silva PMA; Barros M; Saraiva L; Pinto M; Bousbaa H; Cidade H
Pharmaceuticals (Basel); 2023 Jun; 16(6):. PubMed ID: 37375826
[TBL] [Abstract][Full Text] [Related]
3. A Diarylpentanoid with Potential Activation of the p53 Pathway: Combination of in silico Screening Studies, Synthesis, and Biological Activity Evaluation.
Moreira J; Almeida J; Loureiro JB; Ramos H; Palmeira A; Pinto MM; Saraiva L; Cidade H
ChemMedChem; 2021 Oct; 16(19):2969-2981. PubMed ID: 34170069
[TBL] [Abstract][Full Text] [Related]
4. BP-M345 as a Basis for the Discovery of New Diarylpentanoids with Promising Antimitotic Activity.
Moreira J; Silva PMA; Castro E; Saraiva L; Pinto M; Bousbaa H; Cidade H
Int J Mol Sci; 2024 Jan; 25(3):. PubMed ID: 38338967
[TBL] [Abstract][Full Text] [Related]
5. BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity.
Novais P; Silva PMA; Moreira J; Palmeira A; Amorim I; Pinto M; Cidade H; Bousbaa H
Molecules; 2021 Nov; 26(23):. PubMed ID: 34885726
[TBL] [Abstract][Full Text] [Related]
6. Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction.
Soares J; Pereira NA; Monteiro Â; Leão M; Bessa C; Dos Santos DJ; Raimundo L; Queiroz G; Bisio A; Inga A; Pereira C; Santos MM; Saraiva L
Eur J Pharm Sci; 2015 Jan; 66():138-47. PubMed ID: 25312347
[TBL] [Abstract][Full Text] [Related]
7. Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53-MDM2 interaction.
Leão M; Soares J; Gomes S; Raimundo L; Ramos H; Bessa C; Queiroz G; Domingos S; Pinto M; Inga A; Cidade H; Saraiva L
Life Sci; 2015 Dec; 142():60-5. PubMed ID: 26475964
[TBL] [Abstract][Full Text] [Related]
8. Targeting the MDM2-p53 protein-protein interaction with prenylchalcones: Synthesis of a small library and evaluation of potential antitumor activity.
Brandão P; Loureiro JB; Carvalho S; Hamadou MH; Cravo S; Moreira J; Pereira D; Palmeira A; Pinto M; Saraiva L; Cidade H
Eur J Med Chem; 2018 Aug; 156():711-721. PubMed ID: 30041135
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and evaluation of modified chalcone based p53 stabilizing agents.
Iftikhar S; Khan S; Bilal A; Manzoor S; Abdullah M; Emwas AH; Sioud S; Gao X; Chotana GA; Faisal A; Saleem RSZ
Bioorg Med Chem Lett; 2017 Sep; 27(17):4101-4106. PubMed ID: 28743509
[TBL] [Abstract][Full Text] [Related]
10. A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins.
Soares J; Raimundo L; Pereira NA; dos Santos DJ; Pérez M; Queiroz G; Leão M; Santos MM; Saraiva L
Pharmacol Res; 2015; 95-96():42-52. PubMed ID: 25814188
[TBL] [Abstract][Full Text] [Related]
11. Novel p-Functionalized Chromen-4-on-3-yl Chalcones Bearing Astonishing Boronic Acid Moiety as MDM2 Inhibitor: Synthesis, Cytotoxic Evaluation and Simulation Studies.
Bhatia RK; Singh L; Garg R; Kaur M; Yadav M; Madan J; Kancherla S; Pissurlenkar RRS; Coutinho EC
Med Chem; 2020; 16(2):212-228. PubMed ID: 31146672
[TBL] [Abstract][Full Text] [Related]
12. Spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function.
Saxena R; Gupta G; Manohar M; Debnath U; Popli P; Prabhakar YS; Konwar R; Kumar S; Kumar A; Dwivedi A
Int J Biochem Cell Biol; 2016 Jan; 70():105-17. PubMed ID: 26556313
[TBL] [Abstract][Full Text] [Related]
13. One-pot synthesis of spiro(indoline-3,4'-pyrazolo[3,4-b]pyridine)-5'-carbonitriles as p53-MDM2 interaction inhibitors.
Ibrahim HS; Eldehna WM; Fallacara AL; Ahmed ER; Ghabbour HA; Elaasser MM; Botta M; Abou-Seri SM; Abdel-Aziz HA
Future Med Chem; 2018 Dec; 10(24):2771-2789. PubMed ID: 30526032
[TBL] [Abstract][Full Text] [Related]
14. Potency and Selectivity Optimization of Tryptophanol-Derived Oxazoloisoindolinones: Novel p53 Activators in Human Colorectal Cancer.
Barcherini V; Almeida J; Lopes EA; Wang M; Magalhães E Silva D; Mori M; Wang S; Saraiva L; Santos MMM
ChemMedChem; 2021 Jan; 16(1):250-258. PubMed ID: 32737944
[TBL] [Abstract][Full Text] [Related]
15. Design, Synthesis, In Vitro Anti-cancer Activity, ADMET Profile and Molecular Docking of Novel Triazolo[3,4-a]phthalazine Derivatives Targeting VEGFR-2 Enzyme.
El-Helby AA; Sakr H; Ayyad RRA; El-Adl K; Ali MM; Khedr F
Anticancer Agents Med Chem; 2018; 18(8):1184-1196. PubMed ID: 29651967
[TBL] [Abstract][Full Text] [Related]
16. A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome.
Achanta G; Modzelewska A; Feng L; Khan SR; Huang P
Mol Pharmacol; 2006 Jul; 70(1):426-33. PubMed ID: 16636137
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis and in vitro and in vivo antitumour activity of 3-benzylideneindolin-2-one derivatives, a novel class of small-molecule inhibitors of the MDM2-p53 interaction.
Zheng GH; Shen JJ; Zhan YC; Yi H; Xue ST; Wang Z; Ji XY; Li ZR
Eur J Med Chem; 2014 Jun; 81():277-88. PubMed ID: 24852275
[TBL] [Abstract][Full Text] [Related]
18. Design, Synthesis and Bioactivity Evaluation of Novel Chalcone Derivatives Possessing Tryptophan Moiety with Dual Activities of Anti-Cancer and Partially Restoring the Proliferation of Normal Kidney Cells Pre-Treated with Cisplatin.
He M; Yu M; Li C; Meng X; Su J; Zhu Y; Yao R
Anticancer Agents Med Chem; 2022; 22(10):1945-1961. PubMed ID: 34674626
[TBL] [Abstract][Full Text] [Related]
19. Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity.
Farghaly TA; Masaret GS; Muhammad ZA; Harras MF
Bioorg Chem; 2020 May; 98():103761. PubMed ID: 32200332
[TBL] [Abstract][Full Text] [Related]
20. Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors.
Si D; Luo H; Zhang X; Yang K; Wen H; Li W; Liu J
Bioorg Chem; 2021 Oct; 115():105268. PubMed ID: 34426149
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]