BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 37932011)

  • 1. Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR.
    Zong D; Koussa NC; Cornwell JA; Pankajam AV; Kruhlak MJ; Wong N; Chari R; Cappell SD; Nussenzweig A
    Genes Dev; 2023 Oct; 37(19-20):913-928. PubMed ID: 37932011
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targe6ng of WRN and ATR.
    Zong D; Koussa NC; Cornwell JA; Pankajam AV; Kruhlak MJ; Wong N; Chari R; Cappell SD; Nussenzweig A
    bioRxiv; 2023 Jul; ():. PubMed ID: 37662356
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway.
    Su F; Bhattacharya S; Abdisalaam S; Mukherjee S; Yajima H; Yang Y; Mishra R; Srinivasan K; Ghose S; Chen DJ; Yannone SM; Asaithamby A
    Oncotarget; 2016 Jan; 7(1):46-65. PubMed ID: 26695548
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The WRN helicase: resolving a new target in microsatellite unstable cancers.
    van Wietmarschen N; Nathan WJ; Nussenzweig A
    Curr Opin Genet Dev; 2021 Dec; 71():34-38. PubMed ID: 34284257
    [TBL] [Abstract][Full Text] [Related]  

  • 5. WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes.
    Patro BS; Frøhlich R; Bohr VA; Stevnsner T
    J Cell Sci; 2011 Dec; 124(Pt 23):3967-79. PubMed ID: 22159421
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The Werner syndrome protein: linking the replication checkpoint response to genome stability.
    Pichierri P; Ammazzalorso F; Bignami M; Franchitto A
    Aging (Albany NY); 2011 Mar; 3(3):311-8. PubMed ID: 21389352
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
    van Wietmarschen N; Sridharan S; Nathan WJ; Tubbs A; Chan EM; Callen E; Wu W; Belinky F; Tripathi V; Wong N; Foster K; Noorbakhsh J; Garimella K; Cruz-Migoni A; Sommers JA; Huang Y; Borah AA; Smith JT; Kalfon J; Kesten N; Fugger K; Walker RL; Dolzhenko E; Eberle MA; Hayward BE; Usdin K; Freudenreich CH; Brosh RM; West SC; McHugh PJ; Meltzer PS; Bass AJ; Nussenzweig A
    Nature; 2020 Oct; 586(7828):292-298. PubMed ID: 32999459
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress.
    Basile G; Leuzzi G; Pichierri P; Franchitto A
    Nucleic Acids Res; 2014 Nov; 42(20):12628-39. PubMed ID: 25352544
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
    Ferretti S; Hamon J; de Kanter R; Scheufler C; Andraos-Rey R; Barbe S; Bechter E; Blank J; Bordas V; Dammassa E; Decker A; Di Nanni N; Dourdoigne M; Gavioli E; Hattenberger M; Heuser A; Hemmerlin C; Hinrichs J; Kerr G; Laborde L; Jaco I; Núñez EJ; Martus HJ; Quadt C; Reschke M; Romanet V; Schaeffer F; Schoepfer J; Schrapp M; Strang R; Voshol H; Wartmann M; Welly S; Zécri F; Hofmann F; Möbitz H; Cortés-Cros M
    Nature; 2024 May; 629(8011):443-449. PubMed ID: 38658754
    [TBL] [Abstract][Full Text] [Related]  

  • 10. ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.
    Ammazzalorso F; Pirzio LM; Bignami M; Franchitto A; Pichierri P
    EMBO J; 2010 Sep; 29(18):3156-69. PubMed ID: 20802463
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest.
    Sidorova JM; Li N; Folch A; Monnat RJ
    Cell Cycle; 2008 Mar; 7(6):796-807. PubMed ID: 18250621
    [TBL] [Abstract][Full Text] [Related]  

  • 12. WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer.
    Kawasaki T; Ohnishi M; Suemoto Y; Kirkner GJ; Liu Z; Yamamoto H; Loda M; Fuchs CS; Ogino S
    Mod Pathol; 2008 Feb; 21(2):150-8. PubMed ID: 18084250
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle.
    Pichierri P; Rosselli F; Franchitto A
    Oncogene; 2003 Mar; 22(10):1491-500. PubMed ID: 12629512
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling.
    Pichierri P; Nicolai S; Cignolo L; Bignami M; Franchitto A
    Oncogene; 2012 Jun; 31(23):2809-23. PubMed ID: 22002307
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.
    Aggarwal M; Sommers JA; Shoemaker RH; Brosh RM
    Proc Natl Acad Sci U S A; 2011 Jan; 108(4):1525-30. PubMed ID: 21220316
    [TBL] [Abstract][Full Text] [Related]  

  • 16. WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI).
    Chan EM; Foster KJ; Bass AJ
    Cancer Treat Res; 2023; 186():313-328. PubMed ID: 37978143
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
    Aggarwal M; Banerjee T; Sommers JA; Iannascoli C; Pichierri P; Shoemaker RH; Brosh RM
    Cancer Res; 2013 Sep; 73(17):5497-507. PubMed ID: 23867477
    [TBL] [Abstract][Full Text] [Related]  

  • 18. WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
    Chan EM; Shibue T; McFarland JM; Gaeta B; Ghandi M; Dumont N; Gonzalez A; McPartlan JS; Li T; Zhang Y; Bin Liu J; Lazaro JB; Gu P; Piett CG; Apffel A; Ali SO; Deasy R; Keskula P; Ng RWS; Roberts EA; Reznichenko E; Leung L; Alimova M; Schenone M; Islam M; Maruvka YE; Liu Y; Roper J; Raghavan S; Giannakis M; Tseng YY; Nagel ZD; D'Andrea A; Root DE; Boehm JS; Getz G; Chang S; Golub TR; Tsherniak A; Vazquez F; Bass AJ
    Nature; 2019 Apr; 568(7753):551-556. PubMed ID: 30971823
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay.
    Parker MJ; Lee H; Yao S; Irwin S; Hwang S; Belanger K; de Mare SW; Surgenor R; Yan L; Gee P; Morla S; Puyang X; Hsiao P; Zeng H; Zhu P; Korpal M; Dransfield P; Bolduc DM; Larsen NA
    Biochemistry; 2023 Jul; 62(14):2147-2160. PubMed ID: 37403936
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Werner helicase mediates the senescence and cell cycle of leukemia cells by regulating DNA repair pathways.
    Cui X; Hou J; Wang S; Yu J; Cheng S; Yu L; Song FJ; Luo H
    Int J Biol Macromol; 2024 Jan; 255():128305. PubMed ID: 37992942
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.