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8. PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability. Tejwani V; Carroll T; Macartney T; Bandau S; Alabert C; Saredi G; Toth R; Rouse J Sci Rep; 2024 Sep; 14(1):20824. PubMed ID: 39242638 [TBL] [Abstract][Full Text] [Related]
9. Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress. Basile G; Leuzzi G; Pichierri P; Franchitto A Nucleic Acids Res; 2014 Nov; 42(20):12628-39. PubMed ID: 25352544 [TBL] [Abstract][Full Text] [Related]
10. Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers. Ferretti S; Hamon J; de Kanter R; Scheufler C; Andraos-Rey R; Barbe S; Bechter E; Blank J; Bordas V; Dammassa E; Decker A; Di Nanni N; Dourdoigne M; Gavioli E; Hattenberger M; Heuser A; Hemmerlin C; Hinrichs J; Kerr G; Laborde L; Jaco I; Núñez EJ; Martus HJ; Quadt C; Reschke M; Romanet V; Schaeffer F; Schoepfer J; Schrapp M; Strang R; Voshol H; Wartmann M; Welly S; Zécri F; Hofmann F; Möbitz H; Cortés-Cros M Nature; 2024 May; 629(8011):443-449. PubMed ID: 38658754 [TBL] [Abstract][Full Text] [Related]
11. ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery. Ammazzalorso F; Pirzio LM; Bignami M; Franchitto A; Pichierri P EMBO J; 2010 Sep; 29(18):3156-69. PubMed ID: 20802463 [TBL] [Abstract][Full Text] [Related]
12. The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest. Sidorova JM; Li N; Folch A; Monnat RJ Cell Cycle; 2008 Mar; 7(6):796-807. PubMed ID: 18250621 [TBL] [Abstract][Full Text] [Related]
13. WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer. Kawasaki T; Ohnishi M; Suemoto Y; Kirkner GJ; Liu Z; Yamamoto H; Loda M; Fuchs CS; Ogino S Mod Pathol; 2008 Feb; 21(2):150-8. PubMed ID: 18084250 [TBL] [Abstract][Full Text] [Related]
14. Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle. Pichierri P; Rosselli F; Franchitto A Oncogene; 2003 Mar; 22(10):1491-500. PubMed ID: 12629512 [TBL] [Abstract][Full Text] [Related]
15. The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling. Pichierri P; Nicolai S; Cignolo L; Bignami M; Franchitto A Oncogene; 2012 Jun; 31(23):2809-23. PubMed ID: 22002307 [TBL] [Abstract][Full Text] [Related]
16. Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress. Aggarwal M; Sommers JA; Shoemaker RH; Brosh RM Proc Natl Acad Sci U S A; 2011 Jan; 108(4):1525-30. PubMed ID: 21220316 [TBL] [Abstract][Full Text] [Related]
17. WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI). Chan EM; Foster KJ; Bass AJ Cancer Treat Res; 2023; 186():313-328. PubMed ID: 37978143 [TBL] [Abstract][Full Text] [Related]
18. Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Aggarwal M; Banerjee T; Sommers JA; Iannascoli C; Pichierri P; Shoemaker RH; Brosh RM Cancer Res; 2013 Sep; 73(17):5497-507. PubMed ID: 23867477 [TBL] [Abstract][Full Text] [Related]
19. WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Chan EM; Shibue T; McFarland JM; Gaeta B; Ghandi M; Dumont N; Gonzalez A; McPartlan JS; Li T; Zhang Y; Bin Liu J; Lazaro JB; Gu P; Piett CG; Apffel A; Ali SO; Deasy R; Keskula P; Ng RWS; Roberts EA; Reznichenko E; Leung L; Alimova M; Schenone M; Islam M; Maruvka YE; Liu Y; Roper J; Raghavan S; Giannakis M; Tseng YY; Nagel ZD; D'Andrea A; Root DE; Boehm JS; Getz G; Chang S; Golub TR; Tsherniak A; Vazquez F; Bass AJ Nature; 2019 Apr; 568(7753):551-556. PubMed ID: 30971823 [TBL] [Abstract][Full Text] [Related]
20. Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay. Parker MJ; Lee H; Yao S; Irwin S; Hwang S; Belanger K; de Mare SW; Surgenor R; Yan L; Gee P; Morla S; Puyang X; Hsiao P; Zeng H; Zhu P; Korpal M; Dransfield P; Bolduc DM; Larsen NA Biochemistry; 2023 Jul; 62(14):2147-2160. PubMed ID: 37403936 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]