198 related articles for article (PubMed ID: 37942685)
1. Discovery of a Potent Proteolysis Targeting Chimera Enables Targeting the Scaffolding Functions of FK506-Binding Protein 51 (FKBP51).
Geiger TM; Walz M; Meyners C; Kuehn A; Dreizler JK; Sugiarto WO; Maciel EVS; Zheng M; Lermyte F; Hausch F
Angew Chem Int Ed Engl; 2024 Jan; 63(3):e202309706. PubMed ID: 37942685
[TBL] [Abstract][Full Text] [Related]
2. Target protein localization and its impact on PROTAC-mediated degradation.
Simpson LM; Glennie L; Brewer A; Zhao JF; Crooks J; Shpiro N; Sapkota GP
Cell Chem Biol; 2022 Oct; 29(10):1482-1504.e7. PubMed ID: 36075213
[TBL] [Abstract][Full Text] [Related]
3. Journey of Von Hippel-Lindau (VHL) E3 ligase in PROTACs design: From VHL ligands to VHL-based degraders.
Setia N; Almuqdadi HTA; Abid M
Eur J Med Chem; 2024 Feb; 265():116041. PubMed ID: 38199162
[TBL] [Abstract][Full Text] [Related]
4. Expansion of targeted degradation by Gilteritinib-Warheaded PROTACs to ALK fusion proteins.
Yokoo H; Tsuji G; Inoue T; Naito M; Demizu Y; Ohoka N
Bioorg Chem; 2024 Apr; 145():107204. PubMed ID: 38377822
[TBL] [Abstract][Full Text] [Related]
5. Macrocyclic FKBP51 Ligands Define a Transient Binding Mode with Enhanced Selectivity.
Voll AM; Meyners C; Taubert MC; Bajaj T; Heymann T; Merz S; Charalampidou A; Kolos J; Purder PL; Geiger TM; Wessig P; Gassen NC; Bracher A; Hausch F
Angew Chem Int Ed Engl; 2021 Jun; 60(24):13257-13263. PubMed ID: 33843131
[TBL] [Abstract][Full Text] [Related]
6. Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets.
Xiong Y; Zhong Y; Yim H; Yang X; Park KS; Xie L; Poulikakos PI; Han X; Xiong Y; Chen X; Liu J; Jin J
J Am Chem Soc; 2022 Dec; 144(49):22622-22632. PubMed ID: 36448571
[TBL] [Abstract][Full Text] [Related]
7. Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity.
Imaide S; Riching KM; Makukhin N; Vetma V; Whitworth C; Hughes SJ; Trainor N; Mahan SD; Murphy N; Cowan AD; Chan KH; Craigon C; Testa A; Maniaci C; Urh M; Daniels DL; Ciulli A
Nat Chem Biol; 2021 Nov; 17(11):1157-1167. PubMed ID: 34675414
[TBL] [Abstract][Full Text] [Related]
8. Design, synthesis, and biological evaluation of first-in-class indomethacin-based PROTACs degrading SARS-CoV-2 main protease and with broad-spectrum antiviral activity.
Desantis J; Bazzacco A; Eleuteri M; Tuci S; Bianconi E; Macchiarulo A; Mercorelli B; Loregian A; Goracci L
Eur J Med Chem; 2024 Mar; 268():116202. PubMed ID: 38394929
[TBL] [Abstract][Full Text] [Related]
9. Molecular dynamics simulation, binding free energy calculation and unbinding pathway analysis on selectivity difference between FKBP51 and FKBP52: Insight into the molecular mechanism of isoform selectivity.
Shi D; Bai Q; Zhou S; Liu X; Liu H; Yao X
Proteins; 2018 Jan; 86(1):43-56. PubMed ID: 29023988
[TBL] [Abstract][Full Text] [Related]
10. Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer.
Yu X; Li D; Kottur J; Kim HS; Herring LE; Yu Y; Xie L; Hu X; Chen X; Cai L; Liu J; Aggarwal AK; Wang GG; Jin J
J Med Chem; 2023 Dec; 66(23):16168-16186. PubMed ID: 38019706
[TBL] [Abstract][Full Text] [Related]
11. Differential conformational dynamics in the closely homologous FK506-binding domains of FKBP51 and FKBP52.
Mustafi SM; LeMaster DM; Hernández G
Biochem J; 2014 Jul; 461(1):115-23. PubMed ID: 24749623
[TBL] [Abstract][Full Text] [Related]
12. Development of versatile solid-phase methods for syntheses of PROTACs with diverse E3 ligands.
Xu H; Kurohara T; Ohoka N; Tsuji G; Inoue T; Naito M; Demizu Y
Bioorg Med Chem; 2023 May; 86():117293. PubMed ID: 37126968
[TBL] [Abstract][Full Text] [Related]
13. Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation.
Wurz RP; Rui H; Dellamaggiore K; Ghimire-Rijal S; Choi K; Smither K; Amegadzie A; Chen N; Li X; Banerjee A; Chen Q; Mohl D; Vaish A
Nat Commun; 2023 Jul; 14(1):4177. PubMed ID: 37443112
[TBL] [Abstract][Full Text] [Related]
14. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.
Kim K; Lee DH; Park S; Jo SH; Ku B; Park SG; Park BC; Jeon YU; Ahn S; Kang CH; Hwang D; Chae S; Ha JD; Kim S; Hwang JY; Kim JH
Sci Rep; 2019 Dec; 9(1):19654. PubMed ID: 31873151
[TBL] [Abstract][Full Text] [Related]
15. Structure-function analysis of squirrel monkey FK506-binding protein 51, a potent inhibitor of glucocorticoid receptor activity.
Denny WB; Prapapanich V; Smith DF; Scammell JG
Endocrinology; 2005 Jul; 146(7):3194-201. PubMed ID: 15802496
[TBL] [Abstract][Full Text] [Related]
16. In situ albumin-binding and esterase-specifically cleaved BRD4-degrading PROTAC for targeted cancer therapy.
Cho H; Jeon SI; Shim MK; Ahn CH; Kim K
Biomaterials; 2023 Apr; 295():122038. PubMed ID: 36787659
[TBL] [Abstract][Full Text] [Related]
17. The helix 1-3 loop in the glucocorticoid receptor LBD is a regulatory element for FKBP cochaperones.
Cluning C; Ward BK; Rea SL; Arulpragasam A; Fuller PJ; Ratajczak T
Mol Endocrinol; 2013 Jul; 27(7):1020-35. PubMed ID: 23686112
[TBL] [Abstract][Full Text] [Related]
18. Comprehensive Transcriptomic Analysis of Novel Class I HDAC Proteolysis Targeting Chimeras (PROTACs).
Baker IM; Smalley JP; Sabat KA; Hodgkinson JT; Cowley SM
Biochemistry; 2023 Feb; 62(3):645-656. PubMed ID: 35948047
[TBL] [Abstract][Full Text] [Related]
19. FKBP51 and FKBP12.6-Novel and tight interactors of Glomulin.
Hähle A; Geiger TM; Merz S; Meyners C; Tianqi M; Kolos J; Hausch F
PLoS One; 2019; 14(9):e0221926. PubMed ID: 31490997
[TBL] [Abstract][Full Text] [Related]
20. SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate.
Roy MJ; Winkler S; Hughes SJ; Whitworth C; Galant M; Farnaby W; Rumpel K; Ciulli A
ACS Chem Biol; 2019 Mar; 14(3):361-368. PubMed ID: 30721025
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
