BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

158 related articles for article (PubMed ID: 37949232)

  • 1. CBAP regulates the function of Akt-associated TSC protein complexes to modulate mTORC1 signaling.
    Liao WT; Chiang YJ; Yang-Yen HF; Hsu LC; Chang ZF; Yen JJY
    J Biol Chem; 2023 Dec; 299(12):105455. PubMed ID: 37949232
    [TBL] [Abstract][Full Text] [Related]  

  • 2. CBAP modulates Akt-dependent TSC2 phosphorylation to promote Rheb-mTORC1 signaling and growth of T-cell acute lymphoblastic leukemia.
    Chiang YJ; Liao WT; Ho KC; Wang SH; Chen YG; Ho CL; Huang SF; Shih LY; Yang-Yen HF; Yen JJ
    Oncogene; 2019 Feb; 38(9):1432-1447. PubMed ID: 30266989
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Amino Acid-Mediated Intracellular Ca
    Amemiya Y; Nakamura N; Ikeda N; Sugiyama R; Ishii C; Maki M; Shibata H; Takahara T
    Int J Mol Sci; 2021 Jun; 22(13):. PubMed ID: 34198993
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.
    Carroll B; Maetzel D; Maddocks OD; Otten G; Ratcliff M; Smith GR; Dunlop EA; Passos JF; Davies OR; Jaenisch R; Tee AR; Sarkar S; Korolchuk VI
    Elife; 2016 Jan; 5():. PubMed ID: 26742086
    [TBL] [Abstract][Full Text] [Related]  

  • 5. VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activation and cellular transformation.
    Mohan N; Shen Y; Dokmanovic M; Endo Y; Hirsch DS; Wu WJ
    Oncotarget; 2016 Aug; 7(32):52239-52254. PubMed ID: 27409169
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
    Tee AR; Manning BD; Roux PP; Cantley LC; Blenis J
    Curr Biol; 2003 Aug; 13(15):1259-68. PubMed ID: 12906785
    [TBL] [Abstract][Full Text] [Related]  

  • 7. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.
    Gordon BS; Kazi AA; Coleman CS; Dennis MD; Chau V; Jefferson LS; Kimball SR
    Cell Signal; 2014 Mar; 26(3):461-7. PubMed ID: 24316235
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
    Inoki K; Li Y; Xu T; Guan KL
    Genes Dev; 2003 Aug; 17(15):1829-34. PubMed ID: 12869586
    [TBL] [Abstract][Full Text] [Related]  

  • 9. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
    Dibble CC; Elis W; Menon S; Qin W; Klekota J; Asara JM; Finan PM; Kwiatkowski DJ; Murphy LO; Manning BD
    Mol Cell; 2012 Aug; 47(4):535-46. PubMed ID: 22795129
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.
    Huang J; Dibble CC; Matsuzaki M; Manning BD
    Mol Cell Biol; 2008 Jun; 28(12):4104-15. PubMed ID: 18411301
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
    Kang YJ; Lu MK; Guan KL
    Cell Death Differ; 2011 Jan; 18(1):133-44. PubMed ID: 20616807
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway.
    Yoshida S; Hong S; Suzuki T; Nada S; Mannan AM; Wang J; Okada M; Guan KL; Inoki K
    J Biol Chem; 2011 Sep; 286(37):32651-60. PubMed ID: 21784859
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural insights into TSC complex assembly and GAP activity on Rheb.
    Yang H; Yu Z; Chen X; Li J; Li N; Cheng J; Gao N; Yuan HX; Ye D; Guan KL; Xu Y
    Nat Commun; 2021 Jan; 12(1):339. PubMed ID: 33436626
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
    Menon S; Dibble CC; Talbott G; Hoxhaj G; Valvezan AJ; Takahashi H; Cantley LC; Manning BD
    Cell; 2014 Feb; 156(4):771-85. PubMed ID: 24529379
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design of negative-regulating proteins of Rheb/mTORC1 with much-reduced sizes of the tuberous sclerosis protein complex.
    Fu W; Wu G
    Protein Sci; 2023 Aug; 32(8):e4731. PubMed ID: 37462942
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.
    Li Y; Inoki K; Guan KL
    Mol Cell Biol; 2004 Sep; 24(18):7965-75. PubMed ID: 15340059
    [TBL] [Abstract][Full Text] [Related]  

  • 17. MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation.
    Fawal MA; Brandt M; Djouder N
    Dev Cell; 2015 Apr; 33(1):67-81. PubMed ID: 25816988
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.
    Zhang HH; Huang J; Düvel K; Boback B; Wu S; Squillace RM; Wu CL; Manning BD
    PLoS One; 2009 Jul; 4(7):e6189. PubMed ID: 19593385
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex.
    Yasuda S; Sugiura H; Katsurabayashi S; Shimada T; Tanaka H; Takasaki K; Iwasaki K; Kobayashi T; Hino O; Yamagata K
    Sci Rep; 2014 Jun; 4():5155. PubMed ID: 24889507
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes.
    Miyazaki M; McCarthy JJ; Esser KA
    FEBS J; 2010 May; 277(9):2180-91. PubMed ID: 20412061
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.