BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

227 related articles for article (PubMed ID: 37967363)

  • 1. R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription-Replication Conflicts.
    Liu ZS; Sinha S; Bannister M; Song A; Arriaga-Gomez E; McKeeken AJ; Bonner EA; Hanson BK; Sarchi M; Takashima K; Zong D; Corral VM; Nguyen E; Yoo J; Chiraphapphaiboon W; Leibson C; McMahon MC; Rai S; Swisher EM; Sachs Z; Chatla S; Stirewalt DL; Deeg HJ; Skorski T; Papapetrou EP; Walter MJ; Graubert TA; Doulatov S; Lee SC; Nguyen HD
    Cancer Res; 2024 Feb; 84(4):577-597. PubMed ID: 37967363
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes.
    Nguyen HD; Leong WY; Li W; Reddy PNG; Sullivan JD; Walter MJ; Zou L; Graubert TA
    Cancer Res; 2018 Sep; 78(18):5363-5374. PubMed ID: 30054334
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency.
    Gatti M; Imhof R; Huang Q; Baudis M; Altmeyer M
    Cell Rep; 2020 Aug; 32(5):107985. PubMed ID: 32755579
    [TBL] [Abstract][Full Text] [Related]  

  • 4. PARP1 associates with R-loops to promote their resolution and genome stability.
    Laspata N; Kaur P; Mersaoui SY; Muoio D; Liu ZS; Bannister MH; Nguyen HD; Curry C; Pascal JM; Poirier GG; Wang H; Masson JY; Fouquerel E
    Nucleic Acids Res; 2023 Mar; 51(5):2215-2237. PubMed ID: 36794853
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.
    Pettitt SJ; Krastev DB; Brandsma I; Dréan A; Song F; Aleksandrov R; Harrell MI; Menon M; Brough R; Campbell J; Frankum J; Ranes M; Pemberton HN; Rafiq R; Fenwick K; Swain A; Guettler S; Lee JM; Swisher EM; Stoynov S; Yusa K; Ashworth A; Lord CJ
    Nat Commun; 2018 May; 9(1):1849. PubMed ID: 29748565
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Targeting PARP proteins in acute leukemia: DNA damage response inhibition and therapeutic strategies.
    Padella A; Ghelli Luserna Di Rorà A; Marconi G; Ghetti M; Martinelli G; Simonetti G
    J Hematol Oncol; 2022 Jan; 15(1):10. PubMed ID: 35065680
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination-Proficient Pancreatic Cancer.
    Parsels LA; Engelke CG; Parsels J; Flanagan SA; Zhang Q; Tanska D; Wahl DR; Canman CE; Lawrence TS; Morgan MA
    Mol Cancer Ther; 2021 Feb; 20(2):263-273. PubMed ID: 33268569
    [TBL] [Abstract][Full Text] [Related]  

  • 8. XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition.
    Patidar PL; Viera T; Morales JC; Singh N; Motea EA; Khandelwal M; Fattah FJ
    Sci Rep; 2020 Aug; 10(1):14253. PubMed ID: 32859985
    [TBL] [Abstract][Full Text] [Related]  

  • 9. PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response.
    Wurster S; Hennes F; Parplys AC; Seelbach JI; Mansour WY; Zielinski A; Petersen C; Clauditz TS; Münscher A; Friedl AA; Borgmann K
    Oncotarget; 2016 Mar; 7(9):9732-41. PubMed ID: 26799421
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic.
    Cerrato A; Morra F; Celetti A
    J Exp Clin Cancer Res; 2016 Nov; 35(1):179. PubMed ID: 27884198
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders.
    Henning RJ; Bourgeois M; Harbison RD
    Cardiovasc Toxicol; 2018 Dec; 18(6):493-506. PubMed ID: 29968072
    [TBL] [Abstract][Full Text] [Related]  

  • 12. EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer.
    Yamaguchi H; Du Y; Nakai K; Ding M; Chang SS; Hsu JL; Yao J; Wei Y; Nie L; Jiao S; Chang WC; Chen CH; Yu Y; Hortobagyi GN; Hung MC
    Oncogene; 2018 Jan; 37(2):208-217. PubMed ID: 28925391
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Therapeutic vulnerability to PARP1,2 inhibition in RB1-mutant osteosarcoma.
    Zoumpoulidou G; Alvarez-Mendoza C; Mancusi C; Ahmed RM; Denman M; Steele CD; Tarabichi M; Roy E; Davies LR; Manji J; Cristalli C; Scotlandi K; Pillay N; Strauss SJ; Mittnacht S
    Nat Commun; 2021 Dec; 12(1):7064. PubMed ID: 34862364
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Therapeutic Targeting of Poly(ADP-Ribose) Polymerase-1 (PARP1) in Cancer: Current Developments, Therapeutic Strategies, and Future Opportunities.
    Rajawat J; Shukla N; Mishra DP
    Med Res Rev; 2017 Nov; 37(6):1461-1491. PubMed ID: 28510338
    [TBL] [Abstract][Full Text] [Related]  

  • 15. PARP1-mediated PARylation of TonEBP prevents R-loop-associated DNA damage.
    Ye BJ; Kang HJ; Lee-Kwon W; Kwon HM; Choi SY
    DNA Repair (Amst); 2021 Aug; 104():103132. PubMed ID: 34049076
    [TBL] [Abstract][Full Text] [Related]  

  • 16. HDAC inhibitors suppress protein poly(ADP-ribosyl)ation and DNA repair protein levels and phosphorylation status in hematologic cancer cells: implications for their use in combination with PARP inhibitors and chemotherapeutic drugs.
    Valdez BC; Nieto Y; Yuan B; Murray D; Andersson BS
    Oncotarget; 2022 Oct; 13():1122-1135. PubMed ID: 36243940
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Triumphs and challenges in exploiting poly(ADP-ribose) polymerase inhibition to combat triple-negative breast cancer.
    Wooten J; Mavingire N; Damar K; Loaiza-Perez A; Brantley E
    J Cell Physiol; 2023 Aug; 238(8):1625-1640. PubMed ID: 37042191
    [TBL] [Abstract][Full Text] [Related]  

  • 18. PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response.
    Kim C; Wang XD; Yu Y
    Elife; 2020 Aug; 9():. PubMed ID: 32844745
    [TBL] [Abstract][Full Text] [Related]  

  • 19. HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer.
    Ma H; Qi G; Han F; Lu W; Peng J; Li R; Yan S; Yuan C; Kong B
    Cell Death Dis; 2022 Mar; 13(3):263. PubMed ID: 35332131
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models.
    Frederick BA; Gupta R; Atilano-Roque A; Su TT; Raben D
    Radiat Res; 2020 Nov; 194(5):519-531. PubMed ID: 32936912
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.