These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
24. Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy. Schrempf A; Slyskova J; Loizou JI Trends Cancer; 2021 Feb; 7(2):98-111. PubMed ID: 33109489 [TBL] [Abstract][Full Text] [Related]
25. RHINO directs MMEJ to repair DNA breaks in mitosis. Brambati A; Sacco O; Porcella S; Heyza J; Kareh M; Schmidt JC; Sfeir A Science; 2023 Aug; 381(6658):653-660. PubMed ID: 37440612 [TBL] [Abstract][Full Text] [Related]
26. Polθ: emerging synthetic lethal partner in homologous recombination-deficient tumors. Bazan Russo TD; Mujacic C; Di Giovanni E; Vitale MC; Ferrante Bannera C; Randazzo U; Contino S; Bono M; Gristina V; Galvano A; Perez A; Badalamenti G; Russo A; Bazan V; Incorvaia L Cancer Gene Ther; 2024 Nov; 31(11):1619-1631. PubMed ID: 39122831 [TBL] [Abstract][Full Text] [Related]
27. Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination-Deficient Leukemia Cells. Sullivan-Reed K; Toma MM; Drzewiecka M; Nieborowska-Skorska M; Nejati R; Karami A; Wasik MA; Sliwinski T; Skorski T Mol Cancer Res; 2023 Oct; 21(10):1017-1022. PubMed ID: 37358557 [TBL] [Abstract][Full Text] [Related]
28. DNA polymerase θ (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse. Wang Z; Song Y; Li S; Kurian S; Xiang R; Chiba T; Wu X J Biol Chem; 2019 Mar; 294(11):3909-3919. PubMed ID: 30655289 [TBL] [Abstract][Full Text] [Related]
29. POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells. Belan O; Sebald M; Adamowicz M; Anand R; Vancevska A; Neves J; Grinkevich V; Hewitt G; Segura-Bayona S; Bellelli R; Robinson HMR; Higgins GS; Smith GCM; West SC; Rueda DS; Boulton SJ Mol Cell; 2022 Dec; 82(24):4664-4680.e9. PubMed ID: 36455556 [TBL] [Abstract][Full Text] [Related]
30. Contribution of Microhomology to Genome Instability: Connection between DNA Repair and Replication Stress. Jiang Y Int J Mol Sci; 2022 Oct; 23(21):. PubMed ID: 36361724 [TBL] [Abstract][Full Text] [Related]
32. DNA Polymerase θ: A Cancer Drug Target with Reverse Transcriptase Activity. Chen XS; Pomerantz RT Genes (Basel); 2021 Jul; 12(8):. PubMed ID: 34440316 [TBL] [Abstract][Full Text] [Related]
33. The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining. Fleury H; MacEachern MK; Stiefel CM; Anand R; Sempeck C; Nebenfuehr B; Maurer-Alcalá K; Ball K; Proctor B; Belan O; Taylor E; Ortega R; Dodd B; Weatherly L; Dansoko D; Leung JW; Boulton SJ; Arnoult N Mol Cell; 2023 May; 83(9):1429-1445.e8. PubMed ID: 37044098 [TBL] [Abstract][Full Text] [Related]
34. Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi. de Lima LP; Calderano SG; da Silva MS; de Araujo CB; Vasconcelos EJR; Iwai LK; Pereira CA; Fragoso SP; Elias MC Sci Rep; 2019 Feb; 9(1):2888. PubMed ID: 30814563 [TBL] [Abstract][Full Text] [Related]
35. POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis. Llorens-Agost M; Ensminger M; Le HP; Gawai A; Liu J; Cruz-García A; Bhetawal S; Wood RD; Heyer WD; Löbrich M Nat Cell Biol; 2021 Oct; 23(10):1095-1104. PubMed ID: 34616022 [TBL] [Abstract][Full Text] [Related]
36. Small Molecules Targeting DNA Polymerase Theta (POLθ) as Promising Synthetic Lethal Agents for Precision Cancer Therapy. Pismataro MC; Astolfi A; Barreca ML; Pacetti M; Schenone S; Bandiera T; Carbone A; Massari S J Med Chem; 2023 May; 66(10):6498-6522. PubMed ID: 37134182 [TBL] [Abstract][Full Text] [Related]
37. Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells. Goullet de Rugy T; Bashkurov M; Datti A; Betous R; Guitton-Sert L; Cazaux C; Durocher D; Hoffmann JS Biol Open; 2016 Oct; 5(10):1485-1492. PubMed ID: 27612511 [TBL] [Abstract][Full Text] [Related]
38. Template and primer requirements for DNA Pol θ-mediated end joining. He P; Yang W Proc Natl Acad Sci U S A; 2018 Jul; 115(30):7747-7752. PubMed ID: 29987024 [TBL] [Abstract][Full Text] [Related]