BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 37983188)

  • 1. Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant
    Abdelhady R; Senthong P; Eyers CE; Reamtong O; Cowley E; Cannizzaro L; Stimpson J; Cain K; Wilkinson OJ; Williams NH; Barran PE; Margison GP; Williams DM; Povey AC
    Chem Res Toxicol; 2023 Dec; 36(12):1921-1929. PubMed ID: 37983188
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase.
    Senthong P; Millington CL; Wilkinson OJ; Marriott AS; Watson AJ; Reamtong O; Eyers CE; Williams DM; Margison GP; Povey AC
    Nucleic Acids Res; 2013 Mar; 41(5):3047-55. PubMed ID: 23335782
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Kinetics of O(6)-methyl-2'-deoxyguanosine repair by O(6)-alkylguanine DNA alkyltransferase within K-ras gene-derived DNA sequences.
    Guza R; Rajesh M; Fang Q; Pegg AE; Tretyakova N
    Chem Res Toxicol; 2006 Apr; 19(4):531-8. PubMed ID: 16608164
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA.
    Kotandeniya D; Murphy D; Seneviratne U; Guza R; Pegg A; Kanugula S; Tretyakova N
    Chem Res Toxicol; 2011 Nov; 24(11):1966-75. PubMed ID: 21913712
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT).
    Shibata T; Glynn N; McMurry TB; McElhinney RS; Margison GP; Williams DM
    Nucleic Acids Res; 2006; 34(6):1884-91. PubMed ID: 16609128
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis.
    Nyskohus LS; Watson AJ; Margison GP; Le Leu RK; Kim SW; Lockett TJ; Head RJ; Young GP; Hu Y
    Mutat Res Genet Toxicol Environ Mutagen; 2013 Dec; 758(1-2):80-6. PubMed ID: 24140386
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis of oligodeoxyribonucleotides containing a tricyclic thio analogue of
    Abdu K; Aiertza MK; Wilkinson OJ; Senthong P; Craggs TD; Povey AC; Margison GP; Williams DM
    Nucleosides Nucleotides Nucleic Acids; 2020; 39(8):1108-1121. PubMed ID: 32449465
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Repair of O6-carboxymethylguanine adducts by O6-methylguanine-DNA methyltransferase in human colon epithelial cells.
    Kostka T; Empl MT; Seiwert N; Geisen SM; Hoffmann P; Adam J; Seeger B; Shay JW; Christmann M; Sturla SJ; Fahrer J; Steinberg P
    Carcinogenesis; 2021 Aug; 42(8):1110-1118. PubMed ID: 34115837
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O
    Kraus A; McKeague M; Seiwert N; Nagel G; Geisen SM; Ziegler N; Trantakis IA; Kaina B; Thomas AD; Sturla SJ; Fahrer J
    Arch Toxicol; 2019 Feb; 93(2):559-572. PubMed ID: 30446773
    [TBL] [Abstract][Full Text] [Related]  

  • 10. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.
    Kaina B; Christmann M; Naumann S; Roos WP
    DNA Repair (Amst); 2007 Aug; 6(8):1079-99. PubMed ID: 17485253
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A novel DNA damage recognition protein in Schizosaccharomyces pombe.
    Pearson SJ; Wharton S; Watson AJ; Begum G; Butt A; Glynn N; Williams DM; Shibata T; Santibáñez-Koref MF; Margison GP
    Nucleic Acids Res; 2006; 34(8):2347-54. PubMed ID: 16679453
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Conformational change in human DNA repair enzyme O6-methylguanine-DNA methyltransferase upon alkylation of its active site by SN1 (indirect-acting) and SN2 (direct-acting) alkylating agents: breaking a "salt-link".
    Oh HK; Teo AK; Ali RB; Lim A; Ayi TC; Yarosh DB; Li BF
    Biochemistry; 1996 Sep; 35(38):12259-66. PubMed ID: 8823159
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction.
    Göder A; Nagel G; Kraus A; Dörsam B; Seiwert N; Kaina B; Fahrer J
    Carcinogenesis; 2015 Aug; 36(8):817-31. PubMed ID: 25998848
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase.
    Hazra TK; Roy R; Biswas T; Grabowski DT; Pegg AE; Mitra S
    Biochemistry; 1997 May; 36(19):5769-76. PubMed ID: 9153417
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Human colorectal mucosal O6-alkylguanine DNA-alkyltransferase activity and DNA-N7-methylguanine levels in colorectal adenoma cases and matched referents.
    Lees NP; Harrison KL; Hall CN; Margison GP; Povey AC
    Gut; 2007 Mar; 56(3):380-4. PubMed ID: 16891355
    [TBL] [Abstract][Full Text] [Related]  

  • 16. O6-methylguanine-DNA methyltransferase gene: epigenetic silencing and prognostic value in head and neck squamous cell carcinoma.
    Zuo C; Ai L; Ratliff P; Suen JY; Hanna E; Brent TP; Fan CY
    Cancer Epidemiol Biomarkers Prev; 2004 Jun; 13(6):967-75. PubMed ID: 15184253
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Development of a new application of the comet assay to assess levels of O6-methylguanine in genomic DNA (CoMeth).
    Ramos AA; Pedro DF; Lima CF; Collins AR; Pereira-Wilson C
    Free Radic Biol Med; 2013 Jul; 60():41-8. PubMed ID: 23391575
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A method for simultaneous identification of human active and active-site alkylated O6-methylguanine-DNA methyltransferase and its possible application for monitoring human exposure to alkylating carcinogens.
    Ayi TC; Oh HK; Lee TK; Li BF
    Cancer Res; 1994 Jul; 54(14):3726-31. PubMed ID: 8033092
    [TBL] [Abstract][Full Text] [Related]  

  • 19. p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor.
    Bocangel D; Sengupta S; Mitra S; Bhakat KK
    Anticancer Res; 2009 Oct; 29(10):3741-50. PubMed ID: 19846904
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Posttranslational Regulation of O(6)-Methylguanine-DNA Methyltransferase (MGMT) and New Opportunities for Treatment of Brain Cancers.
    Srivenugopal KS; Rawat A; Niture SK; Paranjpe A; Velu C; Venugopal SN; Madala HR; Basak D; Punganuru SR
    Mini Rev Med Chem; 2016; 16(6):455-64. PubMed ID: 26202203
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.