BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

219 related articles for article (PubMed ID: 37984887)

  • 1. The Onset of Molecule-Spanning Dynamics in Heat Shock Protein Hsp90.
    Sohmen B; Beck C; Frank V; Seydel T; Hoffmann I; Hermann B; NĂ¼esch M; Grimaldo M; Schreiber F; Wolf S; Roosen-Runge F; Hugel T
    Adv Sci (Weinh); 2023 Dec; 10(36):e2304262. PubMed ID: 37984887
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Exploring Mechanisms of Allosteric Regulation and Communication Switching in the Multiprotein Regulatory Complexes of the Hsp90 Chaperone with Cochaperones and Client Proteins: Atomistic Insights from Integrative Biophysical Modeling and Network Analysis of Conformational Landscapes.
    Verkhivker GM
    J Mol Biol; 2022 Sep; 434(17):167506. PubMed ID: 35202628
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Extended conformational states dominate the Hsp90 chaperone dynamics.
    Jussupow A; Lopez A; Baumgart M; Mader SL; Sattler M; Kaila VRI
    J Biol Chem; 2022 Jul; 298(7):102101. PubMed ID: 35667441
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90.
    Rehn A; Moroni E; Zierer BK; Tippel F; Morra G; John C; Richter K; Colombo G; Buchner J
    J Mol Biol; 2016 Nov; 428(22):4559-4571. PubMed ID: 27663270
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Probing molecular mechanisms of the Hsp90 chaperone: biophysical modeling identifies key regulators of functional dynamics.
    Dixit A; Verkhivker GM
    PLoS One; 2012; 7(5):e37605. PubMed ID: 22624053
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Allosteric Mechanism of the Hsp90 Chaperone Interactions with Cochaperones and Client Proteins by Modulating Communication Spines of Coupled Regulatory Switches: Integrative Atomistic Modeling of Hsp90 Signaling in Dynamic Interaction Networks.
    Astl L; Stetz G; Verkhivker GM
    J Chem Inf Model; 2020 Jul; 60(7):3616-3631. PubMed ID: 32519853
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Computational modeling of allosteric regulation in the hsp90 chaperones: a statistical ensemble analysis of protein structure networks and allosteric communications.
    Blacklock K; Verkhivker GM
    PLoS Comput Biol; 2014 Jun; 10(6):e1003679. PubMed ID: 24922508
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Dissecting Molecular Principles of the Hsp90 Chaperone Regulation by Allosteric Modulators Using a Hierarchical Simulation Approach and Network Modeling of Allosteric Interactions: Conformational Selection Dictates the Diversity of Protein Responses and Ligand-Specific Functional Mechanisms.
    Astl L; Stetz G; Verkhivker GM
    J Chem Theory Comput; 2020 Oct; 16(10):6656-6677. PubMed ID: 32941034
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Allosteric regulation of the Hsp90 dynamics and stability by client recruiter cochaperones: protein structure network modeling.
    Blacklock K; Verkhivker GM
    PLoS One; 2014; 9(1):e86547. PubMed ID: 24466147
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex.
    Ali MM; Roe SM; Vaughan CK; Meyer P; Panaretou B; Piper PW; Prodromou C; Pearl LH
    Nature; 2006 Apr; 440(7087):1013-7. PubMed ID: 16625188
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Atomistic simulations and network-based modeling of the Hsp90-Cdc37 chaperone binding with Cdk4 client protein: A mechanism of chaperoning kinase clients by exploiting weak spots of intrinsically dynamic kinase domains.
    Czemeres J; Buse K; Verkhivker GM
    PLoS One; 2017; 12(12):e0190267. PubMed ID: 29267381
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dynamics-based community analysis and perturbation response scanning of allosteric interaction networks in the TRAP1 chaperone structures dissect molecular linkage between conformational asymmetry and sequential ATP hydrolysis.
    Verkhivker GM
    Biochim Biophys Acta Proteins Proteom; 2018 Aug; 1866(8):899-912. PubMed ID: 29684503
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle.
    Siligardi G; Hu B; Panaretou B; Piper PW; Pearl LH; Prodromou C
    J Biol Chem; 2004 Dec; 279(50):51989-98. PubMed ID: 15466438
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Hsp90 chaperone machinery: conformational dynamics and regulation by co-chaperones.
    Li J; Soroka J; Buchner J
    Biochim Biophys Acta; 2012 Mar; 1823(3):624-35. PubMed ID: 21951723
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Modeling signal propagation mechanisms and ligand-based conformational dynamics of the Hsp90 molecular chaperone full-length dimer.
    Morra G; Verkhivker G; Colombo G
    PLoS Comput Biol; 2009 Mar; 5(3):e1000323. PubMed ID: 19300478
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Conformational dynamics of the molecular chaperone Hsp90.
    Krukenberg KA; Street TO; Lavery LA; Agard DA
    Q Rev Biophys; 2011 May; 44(2):229-55. PubMed ID: 21414251
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The Co-chaperone Sba1 connects the ATPase reaction of Hsp90 to the progression of the chaperone cycle.
    Richter K; Walter S; Buchner J
    J Mol Biol; 2004 Oct; 342(5):1403-13. PubMed ID: 15364569
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Using Single-Molecule Optical Tweezers to Study the Conformational Cycle of the Hsp90 Molecular Chaperone.
    Tych K; Rief M
    Methods Mol Biol; 2022; 2478():401-425. PubMed ID: 36063329
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands.
    Vettoretti G; Moroni E; Sattin S; Tao J; Agard DA; Bernardi A; Colombo G
    Sci Rep; 2016 Apr; 6():23830. PubMed ID: 27032695
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle.
    Li J; Richter K; Reinstein J; Buchner J
    Nat Struct Mol Biol; 2013 Mar; 20(3):326-31. PubMed ID: 23396352
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.