BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

117 related articles for article (PubMed ID: 37995644)

  • 21. Design and synthesis of novel pyrazolo[3,4-d]pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy.
    Ibrahim TS; Hawwas MM; Taher ES; Alhakamy NA; Alfaleh MA; Elagawany M; Elgendy B; Zayed GM; Mohamed MFA; Abdel-Samii ZK; Elshaier YAMM
    Bioorg Chem; 2020 Dec; 105():104352. PubMed ID: 33080494
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Synthesis and Anti-Proliferative Evaluations of New Heterocyclic Derivatives Using 5,6,8,9-Tetrahydropyrazolo[5,1-b]quinazolin-7(3H)-one Derivatives Derived from Cyclohexa-1,4-dione.
    Mahmoud MAA; Alsharif MA; Mohareb RM
    Anticancer Agents Med Chem; 2021; 21(4):468-486. PubMed ID: 32445457
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Dual EGFR/VEGFR2 inhibitors and apoptosis inducers: Synthesis and antitumor activity of novel pyrazoline derivatives.
    Alkamaly OM; Altwaijry N; Sabour R; Harras MF
    Arch Pharm (Weinheim); 2021 Apr; 354(4):e2000351. PubMed ID: 33252142
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Design and biological evaluation of 3-substituted quinazoline-2,4(1
    Hassan A; Mubarak FAF; Shehadi IA; Mosallam AM; Temairk H; Badr M; Abdelmonsef AH
    J Enzyme Inhib Med Chem; 2023 Dec; 38(1):2189578. PubMed ID: 36919632
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Structural optimization of 4-(imidazol-5-yl)pyridine derivatives affords broad-spectrum anticancer agents with selective B-RAF
    Ali EMH; Mersal KI; Ammar UM; Zaraei SO; Abdel-Maksoud MS; El-Gamal MI; Haque MM; Das T; Kim EE; Lee JS; Lee KH; Kim HK; Oh CH
    Eur J Pharm Sci; 2022 Apr; 171():106115. PubMed ID: 34995782
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Discovery of novel pyrazolo[3,4-b]pyridine scaffold-based derivatives as potential PIM-1 kinase inhibitors in breast cancer MCF-7 cells.
    Nafie MS; Amer AM; Mohamed AK; Tantawy ES
    Bioorg Med Chem; 2020 Dec; 28(24):115828. PubMed ID: 33166925
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Design, Synthesis, biological Evaluation, and molecular docking studies of novel Pyrazolo[3,4-d]Pyrimidine derivative scaffolds as potent EGFR inhibitors and cell apoptosis inducers.
    Sherbiny FF; Bayoumi AH; El-Morsy AM; Sobhy M; Hagras M
    Bioorg Chem; 2021 Nov; 116():105325. PubMed ID: 34507234
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Novel Pyrazolo[3,4-d]pyrimidines as Potential Cytotoxic Agents: Design, Synthesis, Molecular Docking and CDK2 Inhibition.
    Maher M; Kassab AE; Zaher AF; Mahmoud Z
    Anticancer Agents Med Chem; 2019; 19(11):1368-1381. PubMed ID: 31038080
    [TBL] [Abstract][Full Text] [Related]  

  • 29. New pyrazolopyrimidine derivatives with anticancer activity: Design, synthesis, PIM-1 inhibition, molecular docking study and molecular dynamics.
    Philoppes JN; Khedr MA; Hassan MHA; Kamel G; Lamie PF
    Bioorg Chem; 2020 Jul; 100():103944. PubMed ID: 32450389
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Transforming Type II to Type I c-Met kinase inhibitors via combined scaffold hopping and structure-guided synthesis of new series of 1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4-one derivatives.
    El-Wakil MH; Teleb M
    Bioorg Chem; 2021 Nov; 116():105304. PubMed ID: 34534756
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect.
    Ahmed HEA; El-Nassag MAA; Hassan AH; Okasha RM; Ihmaid S; Fouda AM; Afifi TH; Aljuhani A; El-Agrody AM
    J Enzyme Inhib Med Chem; 2018 Dec; 33(1):1074-1088. PubMed ID: 29923425
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Design, synthesis, and antitumor screening of new thiazole, thiazolopyrimidine, and thiazolotriazine derivatives as potent inhibitors of VEGFR-2.
    Abd Elhameed AA; Ali AR; Ghabbour HA; Bayomi SM; El-Gohary NS
    Drug Dev Res; 2023 Dec; 84(8):1664-1698. PubMed ID: 37661648
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a multistep in vitro assessment.
    Elgiushy HR; Mohamed SH; Taha H; Sawaf H; Hassan Z; Abou-Taleb NA; El-Labbad EM; Hassan AS; Abouzid KAM; Hammad SF
    Bioorg Chem; 2022 Mar; 120():105646. PubMed ID: 35134645
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Selective VEGFR-2 inhibitors: Synthesis of pyridine derivatives, cytotoxicity and apoptosis induction profiling.
    AbdelHaleem A; Mansour AO; AbdelKader M; Arafa RK
    Bioorg Chem; 2020 Oct; 103():104222. PubMed ID: 32889383
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Novel pyrazole-based COX-2 inhibitors as potential anticancer agents: Design, synthesis, cytotoxic effect against resistant cancer cells, cell cycle arrest, apoptosis induction and dual EGFR/Topo-1 inhibition.
    Halim PA; Sharkawi SMZ; Labib MB
    Bioorg Chem; 2023 Feb; 131():106273. PubMed ID: 36444790
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Pyrazolo[3,4-d]pyrimidine-based dual EGFR T790M/HER2 inhibitors: Design, synthesis, structure-activity relationship and biological activity as potential antitumor and anticonvulsant agents.
    Lamie PF; El-Kalaawy AM; Abdel Latif NS; Rashed LA; Philoppes JN
    Eur J Med Chem; 2021 Mar; 214():113222. PubMed ID: 33545637
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Novel antiproliferative agents bearing substituted thieno[2,3-d]pyrimidine scaffold as dual VEGFR-2 and BRAF kinases inhibitors and apoptosis inducers; design, synthesis and molecular docking.
    Hassan RA; Hamed MIA; Abdou AM; El-Dash Y
    Bioorg Chem; 2022 Aug; 125():105861. PubMed ID: 35569190
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Novel Nicotinonitrile Derivatives Bearing Imino Moieties Enhance Apoptosis and Inhibit Tyrosine Kinase.
    El-Hashash MA; El-Bordany EA; Marzouk MI; El-Naggar AM; Nawar TMS; El-Sayed WM
    Anticancer Agents Med Chem; 2018; 18(11):1589-1598. PubMed ID: 29745342
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Dual VEGFR-2/PIM-1 kinase inhibition towards surmounting the resistance to antiangiogenic agents via hybrid pyridine and thienopyridine-based scaffolds: Design, synthesis and biological evaluation.
    Rizk OH; Teleb M; Abu-Serie MM; Shaaban OG
    Bioorg Chem; 2019 Nov; 92():103189. PubMed ID: 31473473
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Design, Synthesis, Molecular Docking, and Biological Studies of New Heterocyclic Compounds Derived from β-Diketones as Novel EGFR and Pim-1 Inhibitors Endowed with AntitumorActivity.
    Mohareb RM; Bagato NMA; Radwan IT
    Anticancer Agents Med Chem; 2022; 22(14):2558-2576. PubMed ID: 35023461
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 6.