These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

107 related articles for article (PubMed ID: 38014186)

  • 1. Allosteric substrate activation of SAMHD1 shapes deoxynucleotide triphosphate imbalances by interconnecting the depletion and biosynthesis of different dNTPs.
    McCown C; Yu CH; Ivanov DN
    bioRxiv; 2023 Nov; ():. PubMed ID: 38014186
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Allosteric Activation of SAMHD1 Protein by Deoxynucleotide Triphosphate (dNTP)-dependent Tetramerization Requires dNTP Concentrations That Are Similar to dNTP Concentrations Observed in Cycling T Cells.
    Wang Z; Bhattacharya A; Villacorta J; Diaz-Griffero F; Ivanov DN
    J Biol Chem; 2016 Oct; 291(41):21407-21413. PubMed ID: 27566548
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural basis of cellular dNTP regulation by SAMHD1.
    Ji X; Tang C; Zhao Q; Wang W; Xiong Y
    Proc Natl Acad Sci U S A; 2014 Oct; 111(41):E4305-14. PubMed ID: 25267621
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
    Zhu CF; Wei W; Peng X; Dong YH; Gong Y; Yu XF
    Acta Crystallogr D Biol Crystallogr; 2015 Mar; 71(Pt 3):516-24. PubMed ID: 25760601
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
    Yu CH; Bhattacharya A; Persaud M; Taylor AB; Wang Z; Bulnes-Ramos A; Xu J; Selyutina A; Martinez-Lopez A; Cano K; Demeler B; Kim B; Hardies SC; Diaz-Griffero F; Ivanov DN
    Nat Commun; 2021 Feb; 12(1):731. PubMed ID: 33531504
    [TBL] [Abstract][Full Text] [Related]  

  • 6. GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state.
    Hansen EC; Seamon KJ; Cravens SL; Stivers JT
    Proc Natl Acad Sci U S A; 2014 May; 111(18):E1843-51. PubMed ID: 24753578
    [TBL] [Abstract][Full Text] [Related]  

  • 7. p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity.
    Valle-Casuso JC; Allouch A; David A; Lenzi GM; Studdard L; Barré-Sinoussi F; Müller-Trutwin M; Kim B; Pancino G; Sáez-Cirión A
    J Virol; 2017 Dec; 91(23):. PubMed ID: 28931685
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.
    Bhattacharya A; Wang Z; White T; Buffone C; Nguyen LA; Shepard CN; Kim B; Demeler B; Diaz-Griffero F; Ivanov DN
    Sci Rep; 2016 Aug; 6():31353. PubMed ID: 27511536
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Allosteric regulation of the human and mouse deoxyribonucleotide triphosphohydrolase sterile α-motif/histidine-aspartate domain-containing protein 1 (SAMHD1).
    Miazzi C; Ferraro P; Pontarin G; Rampazzo C; Reichard P; Bianchi V
    J Biol Chem; 2014 Jun; 289(26):18339-46. PubMed ID: 24828500
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanism of allosteric activation of SAMHD1 by dGTP.
    Ji X; Wu Y; Yan J; Mehrens J; Yang H; DeLucia M; Hao C; Gronenborn AM; Skowronski J; Ahn J; Xiong Y
    Nat Struct Mol Biol; 2013 Nov; 20(11):1304-9. PubMed ID: 24141705
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The missing link: allostery and catalysis in the anti-viral protein SAMHD1.
    Morris ER; Taylor IA
    Biochem Soc Trans; 2019 Aug; 47(4):1013-1027. PubMed ID: 31296733
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Vpx requires active cellular dNTP biosynthesis to effectively counteract the anti-lentivirus activity of SAMHD1 in macrophages.
    Bowen NE; Tao S; Cho YJ; Schinazi RF; Kim B
    J Biol Chem; 2023 Aug; 299(8):104984. PubMed ID: 37390988
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Functionality of Redox-Active Cysteines Is Required for Restriction of Retroviral Replication by SAMHD1.
    Wang Z; Bhattacharya A; White T; Buffone C; McCabe A; Nguyen LA; Shepard CN; Pardo S; Kim B; Weintraub ST; Demeler B; Diaz-Griffero F; Ivanov DN
    Cell Rep; 2018 Jul; 24(4):815-823. PubMed ID: 30044979
    [TBL] [Abstract][Full Text] [Related]  

  • 14. SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons.
    St Gelais C; de Silva S; Amie SM; Coleman CM; Hoy H; Hollenbaugh JA; Kim B; Wu L
    Retrovirology; 2012 Dec; 9():105. PubMed ID: 23231760
    [TBL] [Abstract][Full Text] [Related]  

  • 15. High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP.
    Klemm BP; Sikkema AP; Hsu AL; Horng JC; Hall TMT; Borgnia MJ; Schaaper RM
    J Biol Chem; 2022 Jul; 298(7):102073. PubMed ID: 35643313
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Substrate Specificity of SAMHD1 Triphosphohydrolase Activity Is Controlled by Deoxyribonucleoside Triphosphates and Phosphorylation at Thr592.
    Jang S; Zhou X; Ahn J
    Biochemistry; 2016 Oct; 55(39):5635-5646. PubMed ID: 27588835
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
    Knecht KM; Buzovetsky O; Schneider C; Thomas D; Srikanth V; Kaderali L; Tofoleanu F; Reiss K; Ferreirós N; Geisslinger G; Batista VS; Ji X; Cinatl J; Keppler OT; Xiong Y
    Proc Natl Acad Sci U S A; 2018 Oct; 115(43):E10022-E10031. PubMed ID: 30305425
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
    Bowen NE; Temple J; Shepard C; Oo A; Arizaga F; Kapoor-Vazirani P; Persaud M; Yu CH; Kim DH; Schinazi RF; Ivanov DN; Diaz-Griffero F; Yu DS; Xiong Y; Kim B
    J Biol Chem; 2021 Oct; 297(4):101170. PubMed ID: 34492268
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural basis of allosteric activation of sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates.
    Koharudin LM; Wu Y; DeLucia M; Mehrens J; Gronenborn AM; Ahn J
    J Biol Chem; 2014 Nov; 289(47):32617-27. PubMed ID: 25288794
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A Cyclin-Binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation.
    St Gelais C; Kim SH; Maksimova VV; Buzovetsky O; Knecht KM; Shepard C; Kim B; Xiong Y; Wu L
    J Virol; 2018 Mar; 92(6):. PubMed ID: 29321329
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.