BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

167 related articles for article (PubMed ID: 38030711)

  • 1. Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer's disease in mice.
    Qian Z; Li B; Meng X; Liao J; Wang G; Li Y; Luo Q; Ye K
    Neuropsychopharmacology; 2024 Feb; 49(3):620-630. PubMed ID: 38030711
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Asparagine endopeptidase-targeted Ultrasound-responsive Nanobubbles Alleviate Tau Cleavage and Amyloid-β Deposition in an Alzheimer's Disease Model.
    Mi X; Du H; Guo X; Wu Y; Shen L; Luo Y; Wang D; Su Q; Xiang R; Yue S; Wu S; Gong J; Yang Z; Zhang Y; Tan X
    Acta Biomater; 2022 Mar; 141():388-397. PubMed ID: 35045359
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer's disease via modulating neuropathology and gut microbiota through suppressing C/EBPβ/AEP pathway.
    Xu QQ; Su ZR; Yang W; Zhong M; Xian YF; Lin ZX
    J Neuroinflammation; 2023 Jan; 20(1):19. PubMed ID: 36717922
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pharmacological inhibition of asparaginyl endopeptidase by δ-secretase inhibitor 11 mitigates Alzheimer's disease-related pathologies in a senescence-accelerated mouse model.
    Wang J; Hu HJ; Liu ZK; Liu JJ; Wang SS; Cheng Q; Chen HZ; Song M
    Transl Neurodegener; 2021 Mar; 10(1):12. PubMed ID: 33789744
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology.
    Wu Z; Wang ZH; Liu X; Zhang Z; Gu X; Yu SP; Keene CD; Cheng L; Ye K
    Prog Neurobiol; 2020 Feb; 185():101730. PubMed ID: 31778772
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Imaging asparaginyl endopeptidase (AEP) in the live brain as a biomarker for Alzheimer's disease.
    Wang SS; Liu ZK; Liu JJ; Cheng Q; Wang YX; Liu Y; Ni WW; Chen HZ; Song M
    J Nanobiotechnology; 2021 Aug; 19(1):249. PubMed ID: 34412639
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.
    Zhang Z; Song M; Liu X; Kang SS; Kwon IS; Duong DM; Seyfried NT; Hu WT; Liu Z; Wang JZ; Cheng L; Sun YE; Yu SP; Levey AI; Ye K
    Nat Med; 2014 Nov; 20(11):1254-62. PubMed ID: 25326800
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
    Zhang Z; Obianyo O; Dall E; Du Y; Fu H; Liu X; Kang SS; Song M; Yu SP; Cabrele C; Schubert M; Li X; Wang JZ; Brandstetter H; Ye K
    Nat Commun; 2017 Mar; 8():14740. PubMed ID: 28345579
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Spatiotemporal activation of the C/EBPβ/δ-secretase axis regulates the pathogenesis of Alzheimer's disease.
    Wang H; Liu X; Chen S; Ye K
    Proc Natl Acad Sci U S A; 2018 Dec; 115(52):E12427-E12434. PubMed ID: 30530690
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases.
    Zhang Z; Xie M; Ye K
    Expert Opin Ther Targets; 2016 Oct; 20(10):1237-45. PubMed ID: 27115710
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease.
    Zhang Z; Song M; Liu X; Su Kang S; Duong DM; Seyfried NT; Cao X; Cheng L; Sun YE; Ping Yu S; Jia J; Levey AI; Ye K
    Nat Commun; 2015 Nov; 6():8762. PubMed ID: 26549211
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Spinal cord injury-activated C/EBPβ-AEP axis mediates cognitive impairment through APP C586/Tau N368 fragments spreading.
    Wu Z; Zhu R; Yu Y; Wang J; Hu X; Xu W; Ren Y; Li C; Zeng Z; Ma B; Xie N; Lin G; Ma B; Zhu R; Ye K; Cheng L
    Prog Neurobiol; 2023 Aug; 227():102467. PubMed ID: 37257680
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pharmacological Inhibition of the Asparaginyl Endopeptidase (AEP) in an Alzheimer's Disease Model Improves the Survival and Efficacy of Transplanted Neural Stem Cells.
    Cheng Q; Ma X; Liu J; Feng X; Liu Y; Wang Y; Ni W; Song M
    Int J Mol Sci; 2023 Apr; 24(9):. PubMed ID: 37175445
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Gut inflammation triggers C/EBPβ/δ-secretase-dependent gut-to-brain propagation of Aβ and Tau fibrils in Alzheimer's disease.
    Chen C; Zhou Y; Wang H; Alam A; Kang SS; Ahn EH; Liu X; Jia J; Ye K
    EMBO J; 2021 Sep; 40(17):e106320. PubMed ID: 34260075
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The Asparaginyl Endopeptidase Legumain: An Emerging Therapeutic Target and Potential Biomarker for Alzheimer's Disease.
    Song M
    Int J Mol Sci; 2022 Sep; 23(18):. PubMed ID: 36142134
    [TBL] [Abstract][Full Text] [Related]  

  • 16. APP/PS1 mice overexpressing SREBP-2 exhibit combined Aβ accumulation and tau pathology underlying Alzheimer's disease.
    Barbero-Camps E; Fernández A; Martínez L; Fernández-Checa JC; Colell A
    Hum Mol Genet; 2013 Sep; 22(17):3460-76. PubMed ID: 23648430
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer's disease.
    Liao J; Chen C; Ahn EH; Liu X; Li H; Edgington-Mitchell LE; Lu Z; Ming S; Ye K
    Neuropharmacology; 2021 Oct; 197():108737. PubMed ID: 34343610
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Neuronal ApoE4 stimulates C/EBPβ activation, promoting Alzheimer's disease pathology in a mouse model.
    Wang ZH; Xia Y; Wu Z; Kang SS; Zhang JC; Liu P; Liu X; Song W; Huin V; Dhaenens CM; Yu SP; Wang XC; Ye K
    Prog Neurobiol; 2022 Feb; 209():102212. PubMed ID: 34958873
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Asparagine Endopeptidase (δ Secretase), an Enzyme Implicated in Alzheimer's Disease Pathology, Is an Inhibitor of Axon Regeneration in Peripheral Nerves.
    English AW; Liu X; Mistretta OC; Ward PJ; Ye K
    eNeuro; 2021; 8(1):. PubMed ID: 33323399
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease.
    Kang SS; Ahn EH; Ye K
    Exp Mol Med; 2020 Aug; 52(8):1275-1287. PubMed ID: 32859953
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.