These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. Genome-Wide CRISPR Screens Reveal ZATT as a Synthetic Lethal Target of TOP2-Poison Etoposide That Can Act in a TDP2-Independent Pathway. Park JM; Zhang H; Nie L; Wang C; Huang M; Feng X; Tang M; Chen Z; Xiong Y; Lee N; Li S; Yin L; Hart T; Chen J Int J Mol Sci; 2023 Mar; 24(7):. PubMed ID: 37047518 [TBL] [Abstract][Full Text] [Related]
3. Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms. Tsuda M; Kitamasu K; Hosokawa S; Nakano T; Ide H Nucleosides Nucleotides Nucleic Acids; 2020; 39(1-3):170-184. PubMed ID: 31608820 [TBL] [Abstract][Full Text] [Related]
4. RAD54L2-mediated DNA damage avoidance pathway specifically preserves genome integrity in response to topoisomerase 2 poisons. Zhang H; Xiong Y; Sun Y; Park JM; Su D; Feng X; Keast S; Tang M; Huang M; Wang C; Srivastava M; Yang C; Zhu D; Chen Z; Li S; Yin L; Pommier Y; Chen J Sci Adv; 2023 Dec; 9(49):eadi6681. PubMed ID: 38055811 [TBL] [Abstract][Full Text] [Related]
5. ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links. Schellenberg MJ; Lieberman JA; Herrero-Ruiz A; Butler LR; Williams JG; Muñoz-Cabello AM; Mueller GA; London RE; Cortés-Ledesma F; Williams RS Science; 2017 Sep; 357(6358):1412-1416. PubMed ID: 28912134 [TBL] [Abstract][Full Text] [Related]
6. Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2). Gao R; Schellenberg MJ; Huang SY; Abdelmalak M; Marchand C; Nitiss KC; Nitiss JL; Williams RS; Pommier Y J Biol Chem; 2014 Jun; 289(26):17960-9. PubMed ID: 24808172 [TBL] [Abstract][Full Text] [Related]
8. Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes. Lee KC; Swan RL; Sondka Z; Padget K; Cowell IG; Austin CA Int J Mol Sci; 2018 Jul; 19(7):. PubMed ID: 30011940 [TBL] [Abstract][Full Text] [Related]
9. TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands. Al Mahmud MR; Ishii K; Bernal-Lozano C; Delgado-Sainz I; Toi M; Akamatsu S; Fukumoto M; Watanabe M; Takeda S; Cortés-Ledesma F; Sasanuma H Genes Cells; 2020 Jul; 25(7):450-465. PubMed ID: 32277721 [TBL] [Abstract][Full Text] [Related]
10. TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo. Gómez-Herreros F; Romero-Granados R; Zeng Z; Alvarez-Quilón A; Quintero C; Ju L; Umans L; Vermeire L; Huylebroeck D; Caldecott KW; Cortés-Ledesma F PLoS Genet; 2013; 9(3):e1003226. PubMed ID: 23505375 [TBL] [Abstract][Full Text] [Related]
11. Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity. Sciascia N; Wu W; Zong D; Sun Y; Wong N; John S; Wangsa D; Ried T; Bunting SF; Pommier Y; Nussenzweig A Elife; 2020 Feb; 9():. PubMed ID: 32057297 [TBL] [Abstract][Full Text] [Related]
12. Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA. Morimoto S; Tsuda M; Bunch H; Sasanuma H; Austin C; Takeda S Genes (Basel); 2019 Oct; 10(11):. PubMed ID: 31671674 [TBL] [Abstract][Full Text] [Related]
13. Molecular mechanisms of topoisomerase 2 DNA-protein crosslink resolution. Riccio AA; Schellenberg MJ; Williams RS Cell Mol Life Sci; 2020 Jan; 77(1):81-91. PubMed ID: 31728578 [TBL] [Abstract][Full Text] [Related]
14. BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes. Sasanuma H; Tsuda M; Morimoto S; Saha LK; Rahman MM; Kiyooka Y; Fujiike H; Cherniack AD; Itou J; Callen Moreu E; Toi M; Nakada S; Tanaka H; Tsutsui K; Yamada S; Nussenzweig A; Takeda S Proc Natl Acad Sci U S A; 2018 Nov; 115(45):E10642-E10651. PubMed ID: 30352856 [TBL] [Abstract][Full Text] [Related]
15. MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner. Shu J; Jiang J; Wang X; Yang X; Zhao G; Cai T Cell Death Dis; 2024 Jan; 15(1):83. PubMed ID: 38263255 [TBL] [Abstract][Full Text] [Related]
16. Physiological concentrations of glucocorticoids induce pathological DNA double-strand breaks. Akter S; Shimba A; Ikuta K; Mahmud MRA; Yamada S; Sasanuma H; Tsuda M; Sone M; Ago Y; Murai K; Tanaka H; Takeda S Genes Cells; 2023 Jan; 28(1):53-67. PubMed ID: 36415926 [TBL] [Abstract][Full Text] [Related]
17. Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding. Shimizu N; Hamada Y; Morozumi R; Yamamoto J; Iwai S; Sugiyama KI; Ide H; Tsuda M J Biol Chem; 2023 Aug; 299(8):104988. PubMed ID: 37392847 [TBL] [Abstract][Full Text] [Related]
19. TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage. Zeng Z; Cortés-Ledesma F; El Khamisy SF; Caldecott KW J Biol Chem; 2011 Jan; 286(1):403-9. PubMed ID: 21030584 [TBL] [Abstract][Full Text] [Related]
20. Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Schellenberg MJ; Perera L; Strom CN; Waters CA; Monian B; Appel CD; Vilas CK; Williams JG; Ramsden DA; Williams RS Nucleic Acids Res; 2016 May; 44(8):3829-44. PubMed ID: 27060144 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]