BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

130 related articles for article (PubMed ID: 38086241)

  • 1. Design and synthesis of luotonin A-derived topoisomerase targeting scaffold with potent antitumor effect and low genotoxicity.
    Li XW; Fang SJ; Li YZ; Qin LQ; Chen NY; Zheng B; Mo DL; Su GF; Su JC; Pan CX
    Bioorg Chem; 2024 Feb; 143():107015. PubMed ID: 38086241
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design and Synthesis of Arylnaphthalene Lignan Lactone Derivatives as Potent Topoisomerase Inhibitors.
    Chen W; Feng Z; Hu D; Meng J
    Med Chem; 2021; 17(8):856-865. PubMed ID: 32520691
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Recent advances in the development of dual topoisomerase I and II inhibitors as anticancer drugs.
    Salerno S; Da Settimo F; Taliani S; Simorini F; La Motta C; Fornaciari G; Marini AM
    Curr Med Chem; 2010; 17(35):4270-90. PubMed ID: 20939813
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors.
    My Van HT; Woo H; Jeong HM; Khadka DB; Yang SH; Zhao C; Jin Y; Lee ES; Youl Lee K; Kwon Y; Cho WJ
    Eur J Med Chem; 2014 Jul; 82():181-94. PubMed ID: 24904965
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Optimization of the Natural Product Calothrixin A to Discover Novel Dual Topoisomerase I and II Inhibitors with Improved Anticancer Activity.
    Yang X; Wang ZP; Xiang S; Wang D; Zhao Y; Luo D; Qiu Y; Huang C; Guo J; Dai Y; Zhang SL; He Y
    J Med Chem; 2022 Jun; 65(11):8040-8061. PubMed ID: 35612499
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents.
    Thapa P; Kadayat TM; Park S; Shin S; Thapa Magar TB; Bist G; Shrestha A; Na Y; Kwon Y; Lee ES
    Bioorg Chem; 2016 Jun; 66():145-59. PubMed ID: 27174797
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and Synthesis of 3,4-diarylpyrrole Analogues as Potent Topoisomerase Inhibitors.
    Chen W; Feng Z; He X; Zhao Q; Liang Q
    Med Chem; 2018; 14(5):485-494. PubMed ID: 29485001
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II.
    Zhuo ST; Li CY; Hu MH; Chen SB; Yao PF; Huang SL; Ou TM; Tan JH; An LK; Li D; Gu LQ; Huang ZS
    Org Biomol Chem; 2013 Jun; 11(24):3989-4005. PubMed ID: 23657605
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors.
    Yao BL; Mai YW; Chen SB; Xie HT; Yao PF; Ou TM; Tan JH; Wang HG; Li D; Huang SL; Gu LQ; Huang ZS
    Eur J Med Chem; 2015 Mar; 92():540-53. PubMed ID: 25599951
    [TBL] [Abstract][Full Text] [Related]  

  • 10. D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity.
    Almansour AI; Kumar RS; Arumugam N; Bianchini G; Menéndez JC; Mohammad F; Dupadahalli K; Altaf M
    Biomed Res Int; 2019; 2019():2514524. PubMed ID: 31815127
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines.
    Kadayat TM; Song C; Shin S; Magar TB; Bist G; Shrestha A; Thapa P; Na Y; Kwon Y; Lee ES
    Bioorg Med Chem; 2015 Jul; 23(13):3499-512. PubMed ID: 26022080
    [TBL] [Abstract][Full Text] [Related]  

  • 12. B-ring-aryl substituted luotonin A analogues with a new binding mode to the topoisomerase 1-DNA complex show enhanced cytotoxic activity.
    González-Ruiz V; Pascua I; Fernández-Marcelo T; Ribelles P; Bianchini G; Sridharan V; Iniesta P; Ramos MT; Olives AI; Martín MA; Menéndez JC
    PLoS One; 2014; 9(5):e95998. PubMed ID: 24830682
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibition of DNA topoisomerases II and/or I by pyrazolo[1,5-a]indole derivatives and their growth inhibitory activities.
    Umemura K; Mizushima T; Katayama H; Kiryu Y; Yamori T; Andoh T
    Mol Pharmacol; 2002 Oct; 62(4):873-80. PubMed ID: 12237334
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity.
    Abdel-Aziz M; Park SE; Abuo-Rahma Gel-D; Sayed MA; Kwon Y
    Eur J Med Chem; 2013 Nov; 69():427-38. PubMed ID: 24090914
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Substituted 2-arylquinazolinones: Design, synthesis, and evaluation of cytotoxicity and inhibition of topoisomerases.
    Khadka DB; Tran GH; Shin S; Nguyen HT; Cao HT; Zhao C; Jin Y; Van HT; Chau MV; Kwon Y; Le TN; Cho WJ
    Eur J Med Chem; 2015 Oct; 103():69-79. PubMed ID: 26334499
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
    Thapa U; Thapa P; Karki R; Yun M; Choi JH; Jahng Y; Lee E; Jeon KH; Na Y; Ha EM; Cho WJ; Kwon Y; Lee ES
    Eur J Med Chem; 2011 Aug; 46(8):3201-9. PubMed ID: 21601964
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I.
    Yu CC; Pan SL; Chao SW; Liu SP; Hsu JL; Yang YC; Li TK; Huang WJ; Guh JH
    Biochem Pharmacol; 2014 Aug; 90(3):320-30. PubMed ID: 24915421
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Topoisomerase inhibitors as anticancer agents: a patent update.
    Khadka DB; Cho WJ
    Expert Opin Ther Pat; 2013 Aug; 23(8):1033-56. PubMed ID: 23611704
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study.
    Karki R; Jun KY; Kadayat TM; Shin S; Thapa Magar TB; Bist G; Shrestha A; Na Y; Kwon Y; Lee ES
    Eur J Med Chem; 2016 May; 113():228-45. PubMed ID: 26945111
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 3-chloromethylene-6-fluorothiochroman-4-one, A novel DNA Topoisomerase poison.
    Wang Y; Chen J; Shen R; Yang C; Ma Z; Liu Y
    Pak J Pharm Sci; 2016 Nov; 29(6 Suppl):2377-2383. PubMed ID: 28167481
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.