BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

155 related articles for article (PubMed ID: 38156414)

  • 1. Quantitative comparison of presenilin protein expression reveals greater activity of PS2-γ-secretase.
    Eccles MK; Main N; Carlessi R; Armstrong AM; Sabale M; Roberts-Mok B; Tirnitz-Parker JEE; Agostino M; Groth D; Fraser PE; Verdile G
    FASEB J; 2024 Jan; 38(1):e23396. PubMed ID: 38156414
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.
    Stanga S; Vrancx C; Tasiaux B; Marinangeli C; Karlström H; Kienlen-Campard P
    J Cell Mol Med; 2018 Feb; 22(2):823-833. PubMed ID: 28994238
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.
    Yonemura Y; Futai E; Yagishita S; Suo S; Tomita T; Iwatsubo T; Ishiura S
    J Biol Chem; 2011 Dec; 286(52):44569-75. PubMed ID: 22074918
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
    Yonemura Y; Futai E; Yagishita S; Kaether C; Ishiura S
    Biochem Biophys Res Commun; 2016 Sep; 478(4):1751-7. PubMed ID: 27608597
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2.
    Pintchovski SA; Schenk DB; Basi GS
    Curr Alzheimer Res; 2013 Jan; 10(1):4-10. PubMed ID: 22950863
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations.
    Kim M; Bezprozvanny I
    Int J Mol Sci; 2021 Dec; 22(24):. PubMed ID: 34948396
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.
    Schmidt FC; Fitz K; Feilen LP; Okochi M; Steiner H; Langosch D
    J Biol Chem; 2023 May; 299(5):104626. PubMed ID: 36944398
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis.
    Islam S; Sun Y; Gao Y; Nakamura T; Noorani AA; Li T; Wong PC; Kimura N; Matsubara E; Kasuga K; Ikeuchi T; Tomita T; Zou K; Michikawa M
    J Neurosci; 2022 Feb; 42(8):1574-1586. PubMed ID: 34987110
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
    Kimberly WT; Xia W; Rahmati T; Wolfe MS; Selkoe DJ
    J Biol Chem; 2000 Feb; 275(5):3173-8. PubMed ID: 10652302
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.
    Watanabe H; Imaizumi K; Cai T; Zhou Z; Tomita T; Okano H
    eNeuro; 2021; 8(2):. PubMed ID: 33608391
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
    Frånberg J; Svensson AI; Winblad B; Karlström H; Frykman S
    Biochem Biophys Res Commun; 2011 Jan; 404(1):564-8. PubMed ID: 21146496
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
    Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
    Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
    Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
    Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
    Steiner H; Capell A; Leimer U; Haass C
    Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
    Lessard CB; Rodriguez E; Ladd TB; Minter LM; Osborne BA; Miele L; Golde TE; Ran Y
    J Biol Chem; 2019 Jul; 294(29):11276-11285. PubMed ID: 31167792
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
    Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
    Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Analysis of Non-Amyloidogenic Mutations in APP Supports Loss of Function Hypothesis of Alzheimer's Disease.
    Kim M; Bezprozvanny I
    Int J Mol Sci; 2023 Jan; 24(3):. PubMed ID: 36768421
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.
    Heilig EA; Xia W; Shen J; Kelleher RJ
    J Biol Chem; 2010 Jul; 285(29):22350-9. PubMed ID: 20460383
    [TBL] [Abstract][Full Text] [Related]  

  • 19. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
    Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
    J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
    Fukumori A; Fluhrer R; Steiner H; Haass C
    J Neurosci; 2010 Jun; 30(23):7853-62. PubMed ID: 20534834
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.