BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

131 related articles for article (PubMed ID: 38157659)

  • 1. Molecular Dynamics and Machine Learning reveal distinguishing mechanisms of Competitive Ligands to perturb α,β-Tubulin.
    Basu D; Dastidar SG
    Comput Biol Chem; 2024 Feb; 108():108004. PubMed ID: 38157659
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discrimination of ligands with different flexibilities resulting from the plasticity of the binding site in tubulin.
    Chakraborti S; Chakravarty D; Gupta S; Chatterji BP; Dhar G; Poddar A; Panda D; Chakrabarti P; Ghosh Dastidar S; Bhattacharyya B
    Biochemistry; 2012 Sep; 51(36):7138-48. PubMed ID: 22891709
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.
    Wang Y; Zhang H; Gigant B; Yu Y; Wu Y; Chen X; Lai Q; Yang Z; Chen Q; Yang J
    FEBS J; 2016 Jan; 283(1):102-11. PubMed ID: 26462166
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The interaction of the B-ring of colchicine with alpha-tubulin: a novel footprinting approach.
    Chaudhuri AR; Seetharamalu P; Schwarz PM; Hausheer FH; Ludueña RF
    J Mol Biol; 2000 Nov; 303(5):679-92. PubMed ID: 11061968
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Linkages in tubulin-colchicine functions: the role of the ring C (C') oxygens and ring B in the controls.
    Pérez-Ramírez B; Gorbunoff MJ; Timasheff SN
    Biochemistry; 1998 Feb; 37(6):1646-61. PubMed ID: 9484236
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization.
    Prota AE; Danel F; Bachmann F; Bargsten K; Buey RM; Pohlmann J; Reinelt S; Lane H; Steinmetz MO
    J Mol Biol; 2014 Apr; 426(8):1848-60. PubMed ID: 24530796
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Tubulin inhibitors: Discovery of a new scaffold targeting extra-binding residues within the colchicine site through anchoring substituents properly adapted to their pocket by a semi-flexible linker.
    Maklad RM; AbdelHafez EMN; Abdelhamid D; Aly OM
    Bioorg Chem; 2020 Jun; 99():103767. PubMed ID: 32325332
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Docking study of ligands into the colchicine binding site of tubulin.
    Farce A; Loge C; Gallet S; Lebegue N; Carato P; Chavatte P; Berthelot P; Lesieur D
    J Enzyme Inhib Med Chem; 2004 Dec; 19(6):541-7. PubMed ID: 15662957
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Insight into microtubule destabilization mechanism of 3,4,5-trimethoxyphenyl indanone derivatives using molecular dynamics simulation and conformational modes analysis.
    Tripathi S; Srivastava G; Singh A; Prakasham AP; Negi AS; Sharma A
    J Comput Aided Mol Des; 2018 Apr; 32(4):559-572. PubMed ID: 29516382
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanisms of influence of the microtubule over-stabilizing ligands on the structure and intrinsic dynamics of α,β-Tubulin.
    Basu D; Majumdar S; Mandal N; Dastidar SG
    Comput Biol Chem; 2022 Feb; 96():107617. PubMed ID: 34942453
    [TBL] [Abstract][Full Text] [Related]  

  • 11. High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design.
    Bueno O; Estévez Gallego J; Martins S; Prota AE; Gago F; Gómez-SanJuan A; Camarasa MJ; Barasoain I; Steinmetz MO; Díaz JF; Pérez-Pérez MJ; Liekens S; Priego EM
    Sci Rep; 2018 Mar; 8(1):4242. PubMed ID: 29523799
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular interactions at the colchicine binding site in tubulin: An X-ray crystallography perspective.
    Wang J; Miller DD; Li W
    Drug Discov Today; 2022 Mar; 27(3):759-776. PubMed ID: 34890803
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Characterization of the colchicine binding site on avian tubulin isotype betaVI.
    Sharma S; Poliks B; Chiauzzi C; Ravindra R; Blanden AR; Bane S
    Biochemistry; 2010 Apr; 49(13):2932-42. PubMed ID: 20178367
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Binding of dihydroxynaphthyl aryl ketones to tubulin colchicine site inhibits microtubule assembly.
    Gutierrez E; Benites J; Valderrama JA; Calderon PB; Verrax J; Nova E; Villanelo F; Maturana D; Escobar C; Lagos R; Monasterio O
    Biochem Biophys Res Commun; 2015 Oct; 466(3):418-25. PubMed ID: 26365353
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structural Changes, Biological Consequences, and Repurposing of Colchicine Site Ligands.
    Montecinos F; Sackett DL
    Biomolecules; 2023 May; 13(5):. PubMed ID: 37238704
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin.
    Bhattacharyya B; Panda D; Gupta S; Banerjee M
    Med Res Rev; 2008 Jan; 28(1):155-83. PubMed ID: 17464966
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Ligand- and structural-based discovery of potential small molecules that target the colchicine site of tubulin for cancer treatment.
    Guo Q; Zhang H; Deng Y; Zhai S; Jiang Z; Zhu D; Wang L
    Eur J Med Chem; 2020 Jun; 196():112328. PubMed ID: 32320841
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Exploring the Origin of Differential Binding Affinities of Human Tubulin Isotypes αβII, αβIII and αβIV for DAMA-Colchicine Using Homology Modelling, Molecular Docking and Molecular Dynamics Simulations.
    Kumbhar BV; Borogaon A; Panda D; Kunwar A
    PLoS One; 2016; 11(5):e0156048. PubMed ID: 27227832
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis of Thicolchicine-Based Conjugates: Investigation towards Bivalent Tubulin/Microtubules Binders.
    Bonandi E; Foschi F; Marucci C; Dapiaggi F; Sironi M; Pieraccini S; Christodoulou MS; de Asís Balaguer F; Díaz JF; Zidar N; Passarella D
    Chempluschem; 2019 Jan; 84(1):98-102. PubMed ID: 31950734
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Potential colchicine binding site inhibitors unraveled by virtual screening, molecular dynamics and MM/PBSA.
    Federico LB; Silva GM; Gomes SQ; Francischini IAG; Barcelos MP; Dos Santos CBR; Costa LT; Campos Rosa JM; de Paula da Silva CHT
    Comput Biol Med; 2021 Oct; 137():104817. PubMed ID: 34488030
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.