119 related articles for article (PubMed ID: 38191231)
1. Preclinical cardiovascular safety assessment of pharmacology-toxicology relationship for a set of novel kinase inhibitors.
Koshman YE; Kohnken R; Logan MR; Mittelstadt SW; Foley CM
Toxicol Sci; 2024 Mar; 198(2):316-327. PubMed ID: 38191231
[TBL] [Abstract][Full Text] [Related]
2. Evaluating Associations Between Nonclinical Cardiovascular Functional Endpoints and Repeat-dose Cardiovascular Toxicity in the Beagle Dog: A Cross-company Initiative.
Milliken P; Aylott M; Edmunds N; Engle S; Ewart L; Fleurance R; Guffroy M; Hargreaves A; Heinz-Taheny K; Kirk S; Leishman D; Leong L; McMahon N; Valentin JP; Watson D; Wallis R; Clements P
Toxicol Sci; 2020 Jul; 176(1):224-235. PubMed ID: 32298455
[TBL] [Abstract][Full Text] [Related]
3. An evaluation of the utility of LVdP/dt
Pugsley MK; Guth B; Chiang AY; Doyle JM; Engwall M; Guillon JM; Hoffmann PK; Koerner JE; Mittelstadt SW; Pierson JB; Rossman EI; Sarazan DR; Parish ST
J Pharmacol Toxicol Methods; 2017; 85():1-21. PubMed ID: 28065821
[TBL] [Abstract][Full Text] [Related]
4. Levosimendan (OR-1259), a myofilament calcium sensitizer, enhances myocardial contractility but does not alter isovolumic relaxation in conscious and anesthetized dogs.
Pagel PS; Harkin CP; Hettrick DA; Warltier DC
Anesthesiology; 1994 Oct; 81(4):974-87. PubMed ID: 7943849
[TBL] [Abstract][Full Text] [Related]
5. The effects of housing conditions on baseline cardiovascular parameters and the sensitivity to detect changes in contractility in telemetry-implanted dogs.
Sadekova N; Boudreau G; Jalbert B; Norton K
J Pharmacol Toxicol Methods; 2016; 81():60-74. PubMed ID: 27163176
[TBL] [Abstract][Full Text] [Related]
6. The cardiovascular pharmacology of ICI 170777 ((6RS)-6-methyl-5-(pyrid-4-yl)-3H,6H-1,3,4- thiadiazin-2-one) a novel compound with positive inotropic and vasodilator effects.
Collis MG; Keddie JR; Rouse W
Br J Pharmacol; 1989 Jun; 97(2):409-18. PubMed ID: 2758224
[TBL] [Abstract][Full Text] [Related]
7. Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs.
Koshman YE; Wilsey AS; Bird BM; Endemann AL; Sadilek S; Treadway J; Martin RL; Polakowski JS; Gintant GA; Mittelstadt SW
J Pharmacol Toxicol Methods; 2020; 103():106871. PubMed ID: 32360993
[TBL] [Abstract][Full Text] [Related]
8. Test of the usefulness of a paradigm to identify potential cardiovascular liabilities of four test articles with varying pharmacological properties in anesthetized guinea pigs.
Kijtawornrat A; Ueyama Y; del Rio C; Sawangkoon S; Buranakarl C; Chaiyabutr N; Hamlin RL
Toxicol Sci; 2014 Feb; 137(2):458-68. PubMed ID: 24189130
[TBL] [Abstract][Full Text] [Related]
9. Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins.
Koshman YE; Wilsey AS; Bird BM; Sadilek S; Weisbecker DA; Ebert PA; Polakowski JS; Gintant GA; Mittelstadt SW; Foley CM
J Pharmacol Toxicol Methods; 2021; 111():107109. PubMed ID: 34416395
[TBL] [Abstract][Full Text] [Related]
10. Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins.
Koshman YE; Wilsey AS; Bird BM; Sadilek S; Weisbecker DA; Ebert PA; Polakowski JS; Gintant GA; Mittelstadt SW; Foley CM
J Pharmacol Toxicol Methods; 2021; 109():107066. PubMed ID: 33838254
[TBL] [Abstract][Full Text] [Related]
11. Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog.
Antic O; Koshman YE; Bird BM; Jasiek G; Wilsey AS; Mittelstadt SW; Foley CM
J Pharmacol Toxicol Methods; 2024; 126():107497. PubMed ID: 38479593
[TBL] [Abstract][Full Text] [Related]
12. Semi-mechanistic modelling platform to assess cardiac contractility and haemodynamics in preclinical cardiovascular safety profiling of new molecular entities.
Venkatasubramanian R; Collins TA; Lesko LJ; Mettetal JT; Trame MN
Br J Pharmacol; 2020 Aug; 177(15):3568-3590. PubMed ID: 32335903
[TBL] [Abstract][Full Text] [Related]
13. In vivo evidence of positive inotropism of EMD 57033 through calcium sensitization.
Haeusler G; Jonas R; Minck KO; Schliep HJ; Schelling P; Weygandt H; Lues I
J Cardiovasc Pharmacol; 1997 May; 29(5):647-55. PubMed ID: 9213208
[TBL] [Abstract][Full Text] [Related]
14. Amrinone enhances myocardial contractility and improves left ventricular diastolic function in conscious and anesthetized chronically instrumented dogs.
Pagel PS; Hettrick DA; Warltier DC
Anesthesiology; 1993 Oct; 79(4):753-65. PubMed ID: 8214755
[TBL] [Abstract][Full Text] [Related]
15. Cardiovascular effects of torcetrapib in conscious and pentobarbital-anesthetized dogs.
Polakowski JS; King AJ; Campbell TJ; Nelson RA; Preusser LC; Kempf-Grote AJ; Marsh KC; Gintant GA; Cox BF; Mittelstadt SW
J Cardiovasc Pharmacol; 2009 Dec; 54(6):543-51. PubMed ID: 19770671
[TBL] [Abstract][Full Text] [Related]
16. Cardiovascular effects of (2RS,3SR)- 2-aminomethyl-2,3,7,8-tetrahydro-2,3,5,8,8-pentamethyl-6H-furo- [2,3-e]indol-7-one hydrochloride (UK-1745), a novel cardiotonic agent with vasodilatory and antiarrhythmic properties.
Uchida Y; Kawada M; Sawanobori K; Sonoki H; Inoue K; Mizuno K; Itou T; Tabunoki Y; Tsukamoto M; Ohashi Y; Kyotani Y; Shimizu N; Fujii M; Nakamura M
Arzneimittelforschung; 1998 Mar; 48(3):219-31. PubMed ID: 9553677
[TBL] [Abstract][Full Text] [Related]
17. Promising approach for the preclinical assessment of cardiac risks using left ventricular pressure-volume loop analyses in anesthetized monkeys.
Ishizaka T; Yoshimatsu Y; Maeda Y; Takasaki W; Chiba K; Mori K
J Pharmacol Toxicol Methods; 2017; 84():1-10. PubMed ID: 27756610
[TBL] [Abstract][Full Text] [Related]
18. The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium.
Guth BD; Chiang AY; Doyle J; Engwall MJ; Guillon JM; Hoffmann P; Koerner J; Mittelstadt S; Ottinger S; Pierson JB; Pugsley MK; Rossman EI; Walisser J; Sarazan RD
J Pharmacol Toxicol Methods; 2015; 75():70-90. PubMed ID: 25843226
[TBL] [Abstract][Full Text] [Related]
19. Translational PK/PD modeling for cardiovascular safety assessment of drug candidates: Methods and examples in drug development.
Caruso A; Frances N; Meille C; Greiter-Wilke A; Hillebrecht A; Lavé T
J Pharmacol Toxicol Methods; 2014; 70(1):73-85. PubMed ID: 24879942
[TBL] [Abstract][Full Text] [Related]
20. Cardiohemodynamic and electrophysiological effects of a selective EP4 receptor agonist ONO--AE1--329 in the halothane-anesthetized dogs.
Nomura H; Nakamura Y; Cao X; Honda A; Katagi J; Ohara H; Izumi-Nakaseko H; Satoh Y; Ando K; Sugiyama A
Eur J Pharmacol; 2015 Aug; 761():217-25. PubMed ID: 26073024
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]