BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

117 related articles for article (PubMed ID: 38224893)

  • 1. Manganese disrupts the maturation and degradation of axonal autophagosome leading to hippocampal synaptic toxicity in mice via the activation of LRRK2 on phosphorylation of Rab10.
    Ma Z; Liu K; Zhang RF; Xie ZX; Liu W; Xu B
    Sci Total Environ; 2024 Mar; 915():170021. PubMed ID: 38224893
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Lysosomal positioning regulates Rab10 phosphorylation at LRRK2
    Kluss JH; Beilina A; Williamson CD; Lewis PA; Cookson MR; Bonet-Ponce L
    Proc Natl Acad Sci U S A; 2022 Oct; 119(43):e2205492119. PubMed ID: 36256825
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction.
    Pajarillo E; Kim S; Digman A; Dutton M; Son DS; Aschner M; Lee E
    J Biol Chem; 2023 Jul; 299(7):104879. PubMed ID: 37269951
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hyperactive LRRK2 kinase impairs the trafficking of axonal autophagosomes.
    Boecker CA; Holzbaur ELF
    Autophagy; 2021 Aug; 17(8):2043-2045. PubMed ID: 34110246
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation.
    Kuwahara T; Funakawa K; Komori T; Sakurai M; Yoshii G; Eguchi T; Fukuda M; Iwatsubo T
    Neurobiol Dis; 2020 Nov; 145():105081. PubMed ID: 32919031
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.
    Wang X; Bondar VV; Davis OB; Maloney MT; Agam M; Chin MY; Cheuk-Nga Ho A; Ghosh R; Leto DE; Joy D; Calvert MEK; Lewcock JW; Di Paolo G; Thorne RG; Sweeney ZK; Henry AG
    Elife; 2023 Oct; 12():. PubMed ID: 37874617
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes.
    Boecker CA; Goldsmith J; Dou D; Cajka GG; Holzbaur ELF
    Curr Biol; 2021 May; 31(10):2140-2154.e6. PubMed ID: 33765413
    [TBL] [Abstract][Full Text] [Related]  

  • 8. LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
    Eguchi T; Kuwahara T; Sakurai M; Komori T; Fujimoto T; Ito G; Yoshimura SI; Harada A; Fukuda M; Koike M; Iwatsubo T
    Proc Natl Acad Sci U S A; 2018 Sep; 115(39):E9115-E9124. PubMed ID: 30209220
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment.
    Kluss JH; Bonet-Ponce L; Lewis PA; Cookson MR
    Neurobiol Dis; 2022 Aug; 170():105769. PubMed ID: 35580815
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Manganese-induced α-synuclein overexpression promotes the accumulation of dysfunctional synaptic vesicles and hippocampal synaptotoxicity by suppressing Rab26-dependent autophagy in presynaptic neurons.
    Ma Z; Liu K; Zhang RF; Xie ZX; Liu W; Deng Y; Li X; Xu B
    Sci Total Environ; 2023 Feb; 858(Pt 1):159753. PubMed ID: 36341850
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The role of microglial LRRK2 in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction.
    Pajarillo E; Kim SH; Digman A; Dutton M; Son DS; Aschner M; Lee E
    bioRxiv; 2023 Apr; ():. PubMed ID: 37066140
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Development of phospho-specific Rab protein antibodies to monitor
    Lis P; Burel S; Steger M; Mann M; Brown F; Diez F; Tonelli F; Holton JL; Ho PW; Ho SL; Chou MY; Polinski NK; Martinez TN; Davies P; Alessi DR
    Biochem J; 2018 Jan; 475(1):1-22. PubMed ID: 29127256
    [TBL] [Abstract][Full Text] [Related]  

  • 13.
    Wauters F; Cornelissen T; Imberechts D; Martin S; Koentjoro B; Sue C; Vangheluwe P; Vandenberghe W
    Autophagy; 2020 Feb; 16(2):203-222. PubMed ID: 30945962
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Role of LRRK2 in manganese-induced neuroinflammation and microglial autophagy.
    Chen J; Su P; Luo W; Chen J
    Biochem Biophys Res Commun; 2018 Mar; 498(1):171-177. PubMed ID: 29408508
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
    Mir R; Tonelli F; Lis P; Macartney T; Polinski NK; Martinez TN; Chou MY; Howden AJM; König T; Hotzy C; Milenkovic I; Brücke T; Zimprich A; Sammler E; Alessi DR
    Biochem J; 2018 Jun; 475(11):1861-1883. PubMed ID: 29743203
    [TBL] [Abstract][Full Text] [Related]  

  • 16. LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.
    Liu Z; Xu E; Zhao HT; Cole T; West AB
    EMBO J; 2020 Oct; 39(20):e104862. PubMed ID: 32853409
    [TBL] [Abstract][Full Text] [Related]  

  • 17. LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner.
    Kania E; Long JS; McEwan DG; Welkenhuyzen K; La Rovere R; Luyten T; Halpin J; Lobbestael E; Baekelandt V; Bultynck G; Ryan KM; Parys JB
    Cell Death Dis; 2023 Jul; 14(7):436. PubMed ID: 37454104
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.
    Ito G; Katsemonova K; Tonelli F; Lis P; Baptista MA; Shpiro N; Duddy G; Wilson S; Ho PW; Ho SL; Reith AD; Alessi DR
    Biochem J; 2016 Sep; 473(17):2671-85. PubMed ID: 27474410
    [TBL] [Abstract][Full Text] [Related]  

  • 19. LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts.
    Kuwahara T; Inoue K; D'Agati VD; Fujimoto T; Eguchi T; Saha S; Wolozin B; Iwatsubo T; Abeliovich A
    Sci Rep; 2016 Jul; 6():29945. PubMed ID: 27424887
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Genetic background influences LRRK2-mediated Rab phosphorylation in the rat brain.
    Kelly K; Chang A; Hastings L; Abdelmotilib H; West AB
    Brain Res; 2021 May; 1759():147372. PubMed ID: 33600829
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.