BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

126 related articles for article (PubMed ID: 38244767)

  • 1. Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase.
    Mpakali A; Barla I; Lu L; Ramesh KM; Thomaidis N; Stern LJ; Giastas P; Stratikos E
    J Mol Biol; 2024 Mar; 436(6):168449. PubMed ID: 38244767
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.
    Mpakali A; Saridakis E; Harlos K; Zhao Y; Kokkala P; Georgiadis D; Giastas P; Papakyriakou A; Stratikos E
    J Med Chem; 2017 Apr; 60(7):2963-2972. PubMed ID: 28328206
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures.
    Diwakarla S; Nylander E; Grönbladh A; Vanga SR; Shamsudin Y; Gutiérrez-de-Terán H; Sävmarker J; Ng L; Pham V; Lundbäck T; Jenmalm-Jensen A; Svensson R; Artursson P; Zelleroth S; Engen K; Rosenström U; Larhed M; Åqvist J; Chai SY; Hallberg M
    ACS Chem Neurosci; 2016 Oct; 7(10):1383-1392. PubMed ID: 27501164
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.
    Hermans SJ; Ascher DB; Hancock NC; Holien JK; Michell BJ; Chai SY; Morton CJ; Parker MW
    Protein Sci; 2015 Feb; 24(2):190-9. PubMed ID: 25408552
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates.
    Svensson F; Engen K; Lundbäck T; Larhed M; Sköld C
    J Chem Inf Model; 2015 Sep; 55(9):1984-93. PubMed ID: 26252078
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Binding to and Inhibition of Insulin-Regulated Aminopeptidase by Macrocyclic Disulfides Enhances Spine Density.
    Diwakarla S; Nylander E; Grönbladh A; Vanga SR; Khan YS; Gutiérrez-de-Terán H; Ng L; Pham V; Sävmarker J; Lundbäck T; Jenmalm-Jensen A; Andersson H; Engen K; Rosenström U; Larhed M; Åqvist J; Chai SY; Hallberg M
    Mol Pharmacol; 2016 Apr; 89(4):413-24. PubMed ID: 26769413
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers.
    Albiston AL; Diwakarla S; Fernando RN; Mountford SJ; Yeatman HR; Morgan B; Pham V; Holien JK; Parker MW; Thompson PE; Chai SY
    Br J Pharmacol; 2011 Sep; 164(1):37-47. PubMed ID: 21470200
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Insulin-regulated aminopeptidase inhibitor-mediated increases in dendritic spine density are facilitated by glucose uptake.
    Seyer B; Diwakarla S; Burns P; Hallberg A; Grӧnbladh A; Hallberg M; Chai SY
    J Neurochem; 2020 May; 153(4):485-494. PubMed ID: 31556456
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase.
    Albiston AL; Pham V; Ye S; Ng L; Lew RA; Thompson PE; Holien JK; Morton CJ; Parker MW; Chai SY
    Mol Pharmacol; 2010 Oct; 78(4):600-7. PubMed ID: 20628006
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Insulin-regulated aminopeptidase inhibitors do not alter glucose handling in normal and diabetic rats.
    Albiston AL; Cacador M; Sinnayah P; Burns P; Chai SY
    J Mol Endocrinol; 2017 May; 58(4):193-198. PubMed ID: 28356324
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cyclic insulin-regulated aminopeptidase (IRAP)/AT4 receptor ligands.
    Axén A; Lindeberg G; Demaegdt H; Vauquelin G; Karlén A; Hallberg M
    J Pept Sci; 2006 Nov; 12(11):705-13. PubMed ID: 16967438
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening.
    Engen K; Rosenström U; Axelsson H; Konda V; Dahllund L; Otrocka M; Sigmundsson K; Nikolaou A; Vauquelin G; Hallberg M; Jenmalm Jensen A; Lundbäck T; Larhed M
    Assay Drug Dev Technol; 2016 Apr; 14(3):180-93. PubMed ID: 27078680
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain.
    Ascher DB; Cromer BA; Morton CJ; Volitakis I; Cherny RA; Albiston AL; Chai SY; Parker MW
    Biochemistry; 2011 Apr; 50(13):2611-22. PubMed ID: 21348480
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Insulin-regulated aminopeptidase: analysis of peptide substrate and inhibitor binding to the catalytic domain.
    Ye S; Chai SY; Lew RA; Albiston AL
    Biol Chem; 2007 Apr; 388(4):399-403. PubMed ID: 17391061
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase.
    Ye S; Chai SY; Lew RA; Ascher DB; Morton CJ; Parker MW; Albiston AL
    Biochem Cell Biol; 2008 Jun; 86(3):251-61. PubMed ID: 18523486
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase.
    Albiston AL; Morton CJ; Ng HL; Pham V; Yeatman HR; Ye S; Fernando RN; De Bundel D; Ascher DB; Mendelsohn FA; Parker MW; Chai SY
    FASEB J; 2008 Dec; 22(12):4209-17. PubMed ID: 18716029
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of Selective Inhibitor Leads by Targeting an Allosteric Site in Insulin-Regulated Aminopeptidase.
    Temponeras I; Chiniadis L; Papakyriakou A; Stratikos E
    Pharmaceuticals (Basel); 2021 Jun; 14(6):. PubMed ID: 34207179
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Angiotensin AT4 receptor ligand interaction with cystinyl aminopeptidase and aminopeptidase N: [125I]Angiotensin IV only binds to the cystinyl aminopeptidase apo-enzyme.
    Demaegdt H; Lenaerts PJ; Swales J; De Backer JP; Laeremans H; Le MT; Kersemans K; Vogel LK; Michotte Y; Vanderheyden P; Vauquelin G
    Eur J Pharmacol; 2006 Sep; 546(1-3):19-27. PubMed ID: 16919623
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effects of ligands or substrate of insulin-regulated aminopeptidase (IRAP) on trophoblast invasion.
    Cohen M; Wuillemin C; Chai SY; Bischof P
    J Pept Sci; 2008 Jul; 14(7):883-7. PubMed ID: 18275097
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Substrate-Induced Facilitated Dissociation of the Competitive Inhibitor from the Active Site of O-Acetyl Serine Sulfhydrylase Reveals a Competitive-Allostery Mechanism.
    Singh AK; Ekka MK; Kaushik A; Pandya V; Singh RP; Banerjee S; Mittal M; Singh V; Kumaran S
    Biochemistry; 2017 Sep; 56(37):5011-5025. PubMed ID: 28805060
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.