168 related articles for article (PubMed ID: 38267530)
1. Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice.
Driscoll R; Hampton L; Abraham NA; Larigan JD; Joseph NF; Hernandez-Vega JC; Geisler S; Yang FC; Deninger M; Tran DT; Khatri N; Godinho BMDC; Kinberger GA; Montagna DR; Hirst WD; Guardado CL; Glajch KE; Arnold HM; Gallant-Behm CL; Weihofen A
Sci Rep; 2024 Jan; 14(1):2061. PubMed ID: 38267530
[TBL] [Abstract][Full Text] [Related]
2. Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.
Pinto RM; Dragileva E; Kirby A; Lloret A; Lopez E; St Claire J; Panigrahi GB; Hou C; Holloway K; Gillis T; Guide JR; Cohen PE; Li GM; Pearson CE; Daly MJ; Wheeler VC
PLoS Genet; 2013 Oct; 9(10):e1003930. PubMed ID: 24204323
[TBL] [Abstract][Full Text] [Related]
3. Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease.
O'Reilly D; Belgrad J; Ferguson C; Summers A; Sapp E; McHugh C; Mathews E; Boudi A; Buchwald J; Ly S; Moreno D; Furgal R; Luu E; Kennedy Z; Hariharan V; Monopoli K; Yang XW; Carroll J; DiFiglia M; Aronin N; Khvorova A
Mol Ther; 2023 Jun; 31(6):1661-1674. PubMed ID: 37177784
[TBL] [Abstract][Full Text] [Related]
4. MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice.
Tomé S; Manley K; Simard JP; Clark GW; Slean MM; Swami M; Shelbourne PF; Tillier ER; Monckton DG; Messer A; Pearson CE
PLoS Genet; 2013; 9(2):e1003280. PubMed ID: 23468640
[TBL] [Abstract][Full Text] [Related]
5. A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.
Aldous SG; Smith EJ; Landles C; Osborne GF; Cañibano-Pico M; Nita IM; Phillips J; Zhang Y; Jin B; Hirst MB; Benn CL; Bond BC; Edelmann W; Greene JR; Bates GP
Brain; 2024 May; 147(5):1784-1798. PubMed ID: 38387080
[TBL] [Abstract][Full Text] [Related]
6. Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.
Kovalenko M; Dragileva E; St Claire J; Gillis T; Guide JR; New J; Dong H; Kucherlapati R; Kucherlapati MH; Ehrlich ME; Lee JM; Wheeler VC
PLoS One; 2012; 7(9):e44273. PubMed ID: 22970194
[TBL] [Abstract][Full Text] [Related]
7. Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice.
Goula AV; Berquist BR; Wilson DM; Wheeler VC; Trottier Y; Merienne K
PLoS Genet; 2009 Dec; 5(12):e1000749. PubMed ID: 19997493
[TBL] [Abstract][Full Text] [Related]
8. A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington's disease mice.
Suelves N; Kirkham-McCarthy L; Lahue RS; Ginés S
Sci Rep; 2017 Jul; 7(1):6082. PubMed ID: 28729730
[TBL] [Abstract][Full Text] [Related]
9. Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice.
Lloret A; Dragileva E; Teed A; Espinola J; Fossale E; Gillis T; Lopez E; Myers RH; MacDonald ME; Wheeler VC
Hum Mol Genet; 2006 Jun; 15(12):2015-24. PubMed ID: 16687439
[TBL] [Abstract][Full Text] [Related]
10. Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes.
Dragileva E; Hendricks A; Teed A; Gillis T; Lopez ET; Friedberg EC; Kucherlapati R; Edelmann W; Lunetta KL; MacDonald ME; Wheeler VC
Neurobiol Dis; 2009 Jan; 33(1):37-47. PubMed ID: 18930147
[TBL] [Abstract][Full Text] [Related]
11. Differential proteomic and genomic profiling of mouse striatal cell model of Huntington's disease and control; probable implications to the disease biology.
Choudhury KR; Das S; Bhattacharyya NP
J Proteomics; 2016 Jan; 132():155-66. PubMed ID: 26581643
[TBL] [Abstract][Full Text] [Related]
12. Loss of TDP-43 promotes somatic CAG repeat expansion in Huntington's disease knock-in mice.
Bai D; Zhu L; Jia Q; Duan X; Chen L; Wang X; Hou J; Jiang G; Yang S; Li S; Li XJ; Yin P
Prog Neurobiol; 2023 Aug; 227():102484. PubMed ID: 37315918
[TBL] [Abstract][Full Text] [Related]
13. A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes.
Ciosi M; Maxwell A; Cumming SA; Hensman Moss DJ; Alshammari AM; Flower MD; Durr A; Leavitt BR; Roos RAC; ; ; Holmans P; Jones L; Langbehn DR; Kwak S; Tabrizi SJ; Monckton DG
EBioMedicine; 2019 Oct; 48():568-580. PubMed ID: 31607598
[TBL] [Abstract][Full Text] [Related]
14. Cellular Analysis of Silencing the Huntington's Disease Gene Using AAV9 Mediated Delivery of Artificial Micro RNA into the Striatum of Q140/Q140 Mice.
Keeler AM; Sapp E; Chase K; Sottosanti E; Danielson E; Pfister E; Stoica L; DiFiglia M; Aronin N; Sena-Esteves M
J Huntingtons Dis; 2016 Oct; 5(3):239-248. PubMed ID: 27689620
[TBL] [Abstract][Full Text] [Related]
15. Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype.
Wegrzynowicz M; Bichell TJ; Soares BD; Loth MK; McGlothan JS; Mori S; Alikhan FS; Hua K; Coughlin JM; Holt HK; Jetter CS; Pomper MG; Osmand AP; Guilarte TR; Bowman AB
J Huntingtons Dis; 2015; 4(1):17-36. PubMed ID: 26333255
[TBL] [Abstract][Full Text] [Related]
16. Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.
Loupe JM; Pinto RM; Kim KH; Gillis T; Mysore JS; Andrew MA; Kovalenko M; Murtha R; Seong I; Gusella JF; Kwak S; Howland D; Lee R; Lee JM; Wheeler VC; MacDonald ME
Hum Mol Genet; 2020 Nov; 29(18):3044-3053. PubMed ID: 32876667
[TBL] [Abstract][Full Text] [Related]
17. Quantification of age-dependent somatic CAG repeat instability in Hdh CAG knock-in mice reveals different expansion dynamics in striatum and liver.
Lee JM; Pinto RM; Gillis T; St Claire JC; Wheeler VC
PLoS One; 2011; 6(8):e23647. PubMed ID: 21897851
[TBL] [Abstract][Full Text] [Related]
18. Transcription elongation and tissue-specific somatic CAG instability.
Goula AV; Stys A; Chan JP; Trottier Y; Festenstein R; Merienne K
PLoS Genet; 2012; 8(11):e1003051. PubMed ID: 23209427
[TBL] [Abstract][Full Text] [Related]
19. Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.
Gall-Duncan T; Luo J; Jurkovic CM; Fischer LA; Fujita K; Deshmukh AL; Harding RJ; Tran S; Mehkary M; Li V; Leib DE; Chen R; Tanaka H; Mason AG; Lévesque D; Khan M; Razzaghi M; Prasolava T; Lanni S; Sato N; Caron MC; Panigrahi GB; Wang P; Lau R; Castel AL; Masson JY; Tippett L; Turner C; Spies M; La Spada AR; Campos EI; Curtis MA; Boisvert FM; Faull RLM; Davidson BL; Nakamori M; Okazawa H; Wold MS; Pearson CE
Cell; 2023 Oct; 186(22):4898-4919.e25. PubMed ID: 37827155
[TBL] [Abstract][Full Text] [Related]
20. Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum.
Wheeler VC; Lebel LA; Vrbanac V; Teed A; te Riele H; MacDonald ME
Hum Mol Genet; 2003 Feb; 12(3):273-81. PubMed ID: 12554681
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]