BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

181 related articles for article (PubMed ID: 38295690)

  • 1. Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2.
    Velez J; Dale B; Park KS; Kaniskan HÜ; Yu X; Jin J
    Eur J Med Chem; 2024 Mar; 267():116154. PubMed ID: 38295690
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2.
    Dale B; Anderson C; Park KS; Kaniskan HÜ; Ma A; Shen Y; Zhang C; Xie L; Chen X; Yu X; Jin J
    ACS Pharmacol Transl Sci; 2022 Jul; 5(7):491-507. PubMed ID: 35837138
    [TBL] [Abstract][Full Text] [Related]  

  • 3. EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis.
    Wang J; Yu X; Gong W; Liu X; Park KS; Ma A; Tsai YH; Shen Y; Onikubo T; Pi WC; Allison DF; Liu J; Chen WY; Cai L; Roeder RG; Jin J; Wang GG
    Nat Cell Biol; 2022 Mar; 24(3):384-399. PubMed ID: 35210568
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis, and evaluation of VHL-based EZH2 degraders for breast cancer.
    Xiao B; Shi Z; Liu J; Huang Q; Shu K; Liu F; Zhi C; Zhang D; Wu L; Yang S; Zeng X; Fan T; Liu Z; Jiang Y
    Bioorg Chem; 2024 Feb; 143():107078. PubMed ID: 38181661
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis and evaluation of EZH2-based PROTACs targeting PRC2 complex in lymphoma.
    Xie H; Xu W; Liang J; Liu Y; Zhuo C; Zou X; Luo W; Xiao J; Lin Y; Chen L; Li H
    Bioorg Chem; 2023 Nov; 140():106762. PubMed ID: 37572533
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, Synthesis, and Evaluation of VHL-Based EZH2 Degraders to Enhance Therapeutic Activity against Lymphoma.
    Tu Y; Sun Y; Qiao S; Luo Y; Liu P; Jiang ZX; Hu Y; Wang Z; Huang P; Wen S
    J Med Chem; 2021 Jul; 64(14):10167-10184. PubMed ID: 34196564
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader.
    Potjewyd F; Turner AW; Beri J; Rectenwald JM; Norris-Drouin JL; Cholensky SH; Margolis DM; Pearce KH; Herring LE; James LI
    Cell Chem Biol; 2020 Jan; 27(1):47-56.e15. PubMed ID: 31831267
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders.
    Diehl CJ; Ciulli A
    Chem Soc Rev; 2022 Oct; 51(19):8216-8257. PubMed ID: 35983982
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands.
    Han X; Zhao L; Xiang W; Qin C; Miao B; Xu T; Wang M; Yang CY; Chinnaswamy K; Stuckey J; Wang S
    J Med Chem; 2019 Dec; 62(24):11218-11231. PubMed ID: 31804827
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A cryptic transactivation domain of EZH2 binds AR and AR's splice variant, promoting oncogene activation and tumorous transformation.
    Wang J; Park KS; Yu X; Gong W; Earp HS; Wang GG; Jin J; Cai L
    Nucleic Acids Res; 2022 Oct; 50(19):10929-10946. PubMed ID: 36300627
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of precision targeting EZH2 degraders for triple-negative breast cancer.
    Wang C; Chen X; Liu X; Lu D; Li S; Qu L; Yin F; Luo H; Zhang Y; Luo Z; Cui N; Kong L; Wang X
    Eur J Med Chem; 2022 Aug; 238():114462. PubMed ID: 35623249
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC).
    Kang CH; Lee DH; Lee CO; Du Ha J; Park CH; Hwang JY
    Biochem Biophys Res Commun; 2018 Oct; 505(2):542-547. PubMed ID: 30274779
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis and activity study of a novel PI3K degradation by hijacking VHL E3 ubiquitin ligase.
    Wang H; Li C; Liu X; Ma M
    Bioorg Med Chem; 2022 May; 61():116707. PubMed ID: 35344835
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies.
    Mei H; Wu H; Yang J; Zhou B; Wang A; Hu C; Qi S; Jiang Z; Zou F; Wang B; Liu F; Chen Y; Wang W; Liu J; Liu Q
    Signal Transduct Target Ther; 2023 Jan; 8(1):18. PubMed ID: 36642705
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of a first-in-class EZH2 selective degrader.
    Ma A; Stratikopoulos E; Park KS; Wei J; Martin TC; Yang X; Schwarz M; Leshchenko V; Rialdi A; Dale B; Lagana A; Guccione E; Parekh S; Parsons R; Jin J
    Nat Chem Biol; 2020 Feb; 16(2):214-222. PubMed ID: 31819273
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of the First-in-class G9a/GLP PROTAC Degrader.
    Velez J; Han Y; Yim H; Yang P; Deng Z; Park KS; Kabir M; Kaniskan HÜ; Xiong Y; Jin J
    bioRxiv; 2024 Feb; ():. PubMed ID: 38464025
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Journey of Von Hippel-Lindau (VHL) E3 ligase in PROTACs design: From VHL ligands to VHL-based degraders.
    Setia N; Almuqdadi HTA; Abid M
    Eur J Med Chem; 2024 Feb; 265():116041. PubMed ID: 38199162
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader.
    Yu X; Wang J; Gong W; Ma A; Shen Y; Zhang C; Liu X; Cai L; Liu J; Wang GG; Jin J
    Oncogene; 2023 Mar; 42(13):994-1009. PubMed ID: 36747009
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Development of decoy oligonucleotide-warheaded chimeric molecules targeting STAT3.
    Shih PC; Naganuma M; Tsuji G; Demizu Y; Naito M
    Bioorg Med Chem; 2023 Nov; 95():117507. PubMed ID: 37922656
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Nanoformulation of EPZ011989 Attenuates EZH2-c-Myb Epigenetic Interaction by Proteasomal Degradation in Acute Myeloid Leukemia.
    Kaundal B; Srivastava AK; Dev A; Mohanbhai SJ; Karmakar S; Roy Choudhury S
    Mol Pharm; 2020 Feb; 17(2):604-621. PubMed ID: 31904978
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.