These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

183 related articles for article (PubMed ID: 38386706)

  • 1. Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
    Greisman JB; Dalton KM; Brookner DE; Klureza MA; Sheehan CJ; Kim IS; Henning RW; Russi S; Hekstra DR
    Proc Natl Acad Sci U S A; 2024 Feb; 121(9):e2313192121. PubMed ID: 38386706
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Resolving conformational changes that mediate a two-step catalytic mechanism in a model enzyme.
    Greisman JB; Dalton KM; Brookner DE; Klureza MA; Sheehan CJ; Kim IS; Henning RW; Russi S; Hekstra DR
    bioRxiv; 2023 Jun; ():. PubMed ID: 37398233
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase.
    Swanwick RS; Maglia G; Tey LH; Allemann RK
    Biochem J; 2006 Feb; 394(Pt 1):259-65. PubMed ID: 16241906
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Multiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase.
    Arora K; Brooks CL
    Top Curr Chem; 2013; 337():165-87. PubMed ID: 23420416
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Comparison of coupled motions in Escherichia coli and Bacillus subtilis dihydrofolate reductase.
    Watney JB; Hammes-Schiffer S
    J Phys Chem B; 2006 May; 110(20):10130-8. PubMed ID: 16706474
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography.
    Wan Q; Bennett BC; Wilson MA; Kovalevsky A; Langan P; Howell EE; Dealwis C
    Proc Natl Acad Sci U S A; 2014 Dec; 111(51):18225-30. PubMed ID: 25453083
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Probing the electrostatics of active site microenvironments along the catalytic cycle for Escherichia coli dihydrofolate reductase.
    Liu CT; Layfield JP; Stewart RJ; French JB; Hanoian P; Asbury JB; Hammes-Schiffer S; Benkovic SJ
    J Am Chem Soc; 2014 Jul; 136(29):10349-60. PubMed ID: 24977791
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Protein mass-modulated effects in the catalytic mechanism of dihydrofolate reductase: beyond promoting vibrations.
    Wang Z; Singh P; Czekster CM; Kohen A; Schramm VL
    J Am Chem Soc; 2014 Jun; 136(23):8333-41. PubMed ID: 24820793
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Energetically most likely substrate and active-site protonation sites and pathways in the catalytic mechanism of dihydrofolate reductase.
    Cummins PL; Gready JE
    J Am Chem Soc; 2001 Apr; 123(15):3418-28. PubMed ID: 11472112
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Distal Regions Regulate Dihydrofolate Reductase-Ligand Interactions.
    Goldstein M; Goodey NM
    Methods Mol Biol; 2021; 2253():185-219. PubMed ID: 33315225
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hydride Transfer in DHFR by Transition Path Sampling, Kinetic Isotope Effects, and Heavy Enzyme Studies.
    Wang Z; Antoniou D; Schwartz SD; Schramm VL
    Biochemistry; 2016 Jan; 55(1):157-66. PubMed ID: 26652185
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effect of Asp122 Mutation on the Hydride Transfer in E. coli DHFR Demonstrates the Goldilocks of Enzyme Flexibility.
    Mhashal AR; Pshetitsky Y; Eitan R; Cheatum CM; Kohen A; Major DT
    J Phys Chem B; 2018 Aug; 122(33):8006-8017. PubMed ID: 30040418
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis.
    Bhabha G; Lee J; Ekiert DC; Gam J; Wilson IA; Dyson HJ; Benkovic SJ; Wright PE
    Science; 2011 Apr; 332(6026):234-8. PubMed ID: 21474759
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Hydride transfer catalysed by Escherichia coli and Bacillus subtilis dihydrofolate reductase: coupled motions and distal mutations.
    Hammes-Schiffer S; Watney JB
    Philos Trans R Soc Lond B Biol Sci; 2006 Aug; 361(1472):1365-73. PubMed ID: 16873124
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant.
    Cameron CE; Benkovic SJ
    Biochemistry; 1997 Dec; 36(50):15792-800. PubMed ID: 9398309
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.
    Venkitakrishnan RP; Zaborowski E; McElheny D; Benkovic SJ; Dyson HJ; Wright PE
    Biochemistry; 2004 Dec; 43(51):16046-55. PubMed ID: 15609999
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Perspectives on electrostatics and conformational motions in enzyme catalysis.
    Hanoian P; Liu CT; Hammes-Schiffer S; Benkovic S
    Acc Chem Res; 2015 Feb; 48(2):482-9. PubMed ID: 25565178
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Solvent effects on catalysis by Escherichia coli dihydrofolate reductase.
    Loveridge EJ; Tey LH; Allemann RK
    J Am Chem Soc; 2010 Jan; 132(3):1137-43. PubMed ID: 20047317
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Analysis of hydride transfer and cofactor fluorescence decay in mutants of dihydrofolate reductase: possible evidence for participation of enzyme molecular motions in catalysis.
    Farnum MF; Magde D; Howell EE; Hirai JT; Warren MS; Grimsley JK; Kraut J
    Biochemistry; 1991 Dec; 30(49):11567-79. PubMed ID: 1747376
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The role of large-scale motions in catalysis by dihydrofolate reductase.
    Loveridge EJ; Tey LH; Behiry EM; Dawson WM; Evans RM; Whittaker SB; Günther UL; Williams C; Crump MP; Allemann RK
    J Am Chem Soc; 2011 Dec; 133(50):20561-70. PubMed ID: 22060818
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.