BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

233 related articles for article (PubMed ID: 38394929)

  • 1. Design, synthesis, and biological evaluation of first-in-class indomethacin-based PROTACs degrading SARS-CoV-2 main protease and with broad-spectrum antiviral activity.
    Desantis J; Bazzacco A; Eleuteri M; Tuci S; Bianconi E; Macchiarulo A; Mercorelli B; Loregian A; Goracci L
    Eur J Med Chem; 2024 Mar; 268():116202. PubMed ID: 38394929
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Indomethacin-based PROTACs as pan-coronavirus antiviral agents.
    Desantis J; Mercorelli B; Celegato M; Croci F; Bazzacco A; Baroni M; Siragusa L; Cruciani G; Loregian A; Goracci L
    Eur J Med Chem; 2021 Dec; 226():113814. PubMed ID: 34534839
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Expansion of targeted degradation by Gilteritinib-Warheaded PROTACs to ALK fusion proteins.
    Yokoo H; Tsuji G; Inoue T; Naito M; Demizu Y; Ohoka N
    Bioorg Chem; 2024 Apr; 145():107204. PubMed ID: 38377822
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Journey of Von Hippel-Lindau (VHL) E3 ligase in PROTACs design: From VHL ligands to VHL-based degraders.
    Setia N; Almuqdadi HTA; Abid M
    Eur J Med Chem; 2024 Feb; 265():116041. PubMed ID: 38199162
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural-based design of HD-TAC7 PROteolysis TArgeting chimeras (PROTACs) candidate transformations to abrogate SARS-CoV-2 infection.
    Zahid S; Ali Y; Rashid S
    J Biomol Struct Dyn; 2023; 41(23):14566-14581. PubMed ID: 36841549
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs.
    Girardini M; Maniaci C; Hughes SJ; Testa A; Ciulli A
    Bioorg Med Chem; 2019 Jun; 27(12):2466-2479. PubMed ID: 30826187
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Protein degradation: a novel computational approach to design protein degrader probes for main protease of SARS-CoV-2.
    Shaheer M; Singh R; Sobhia ME
    J Biomol Struct Dyn; 2022; 40(21):10905-10917. PubMed ID: 34328382
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis.
    Eleuteri M; Desantis J; Cruciani G; Germani R; Goracci L
    Org Biomol Chem; 2024 May; 22(17):3477-3489. PubMed ID: 38602033
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease.
    Alugubelli YR; Xiao J; Khatua K; Kumar S; Sun L; Ma Y; Ma XR; Vulupala VR; Atla S; Blankenship LR; Coleman D; Xie X; Neuman BW; Liu WR; Xu S
    J Med Chem; 2024 Apr; 67(8):6495-6507. PubMed ID: 38608245
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease.
    Alugubelli YR; Xiao J; Khatua K; Kumar S; Ma Y; Ma XR; Vulupala VR; Atla SR; Blankenship L; Coleman D; Neuman BW; Liu WR; Xu S
    bioRxiv; 2023 Sep; ():. PubMed ID: 37808777
    [TBL] [Abstract][Full Text] [Related]  

  • 11. E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones.
    Ishida T; Ciulli A
    SLAS Discov; 2021 Apr; 26(4):484-502. PubMed ID: 33143537
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Development of versatile solid-phase methods for syntheses of PROTACs with diverse E3 ligands.
    Xu H; Kurohara T; Ohoka N; Tsuji G; Inoue T; Naito M; Demizu Y
    Bioorg Med Chem; 2023 May; 86():117293. PubMed ID: 37126968
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Development of VHL-recruiting STING PROTACs that suppress innate immunity.
    Zhu Z; Johnson RL; Zhang Z; Herring LE; Jiang G; Damania B; James LI; Liu P
    Cell Mol Life Sci; 2023 May; 80(6):149. PubMed ID: 37183204
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Target protein localization and its impact on PROTAC-mediated degradation.
    Simpson LM; Glennie L; Brewer A; Zhao JF; Crooks J; Shpiro N; Sapkota GP
    Cell Chem Biol; 2022 Oct; 29(10):1482-1504.e7. PubMed ID: 36075213
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of E3 Ligase Ligands for Target Protein Degradation.
    Lee J; Lee Y; Jung YM; Park JH; Yoo HS; Park J
    Molecules; 2022 Oct; 27(19):. PubMed ID: 36235052
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.
    Kim K; Lee DH; Park S; Jo SH; Ku B; Park SG; Park BC; Jeon YU; Ahn S; Kang CH; Hwang D; Chae S; Ha JD; Kim S; Hwang JY; Kim JH
    Sci Rep; 2019 Dec; 9(1):19654. PubMed ID: 31873151
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets.
    Xiong Y; Zhong Y; Yim H; Yang X; Park KS; Xie L; Poulikakos PI; Han X; Xiong Y; Chen X; Liu J; Jin J
    J Am Chem Soc; 2022 Dec; 144(49):22622-22632. PubMed ID: 36448571
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Fluorescence theranostic PROTACs for real-time visualization of ERα degradation.
    Wang X; Xin L; Deng X; Dong C; Hu G; Zhou HB
    Eur J Med Chem; 2024 Mar; 267():116184. PubMed ID: 38320426
    [TBL] [Abstract][Full Text] [Related]  

  • 19. DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance.
    Schröder M; Renatus M; Liang X; Meili F; Zoller T; Ferrand S; Gauter F; Li X; Sigoillot F; Gleim S; Stachyra TM; Thomas JR; Begue D; Khoshouei M; Lefeuvre P; Andraos-Rey R; Chung B; Ma R; Pinch B; Hofmann A; Schirle M; Schmiedeberg N; Imbach P; Gorses D; Calkins K; Bauer-Probst B; Maschlej M; Niederst M; Maher R; Henault M; Alford J; Ahrne E; Tordella L; Hollingworth G; Thomä NH; Vulpetti A; Radimerski T; Holzer P; Carbonneau S; Thoma CR
    Nat Commun; 2024 Jan; 15(1):275. PubMed ID: 38177131
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis and biological evaluation of the tumor hypoxia-activated PROTACs bearing caged CRBN E3 ligase ligands.
    Cheng W; Li S; Han S; Miao R; Wang S; Liu C; Wei H; Tian X; Zhang X
    Bioorg Med Chem; 2023 Mar; 82():117237. PubMed ID: 36906965
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.