179 related articles for article (PubMed ID: 38399977)
1. Optimizing the Multimerization Properties of Quinoline-Based Allosteric HIV-1 Integrase Inhibitors.
Sun J; Kessl JJ
Viruses; 2024 Jan; 16(2):. PubMed ID: 38399977
[TBL] [Abstract][Full Text] [Related]
2. Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors.
Dinh LP; Sun J; Glenn CD; Patel K; Pigza JA; Donahue MG; Yet L; Kessl JJ
Viruses; 2022 Jul; 14(7):. PubMed ID: 35891446
[TBL] [Abstract][Full Text] [Related]
3. Optimized binding of substituted quinoline ALLINIs within the HIV-1 integrase oligomer.
Sun J; Patel K; Hume J; Pigza JA; Donahue MG; Kessl JJ
J Biol Chem; 2021; 296():100363. PubMed ID: 33539919
[TBL] [Abstract][Full Text] [Related]
4. The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
Feng L; Sharma A; Slaughter A; Jena N; Koh Y; Shkriabai N; Larue RC; Patel PA; Mitsuya H; Kessl JJ; Engelman A; Fuchs JR; Kvaratskhelia M
J Biol Chem; 2013 May; 288(22):15813-20. PubMed ID: 23615903
[TBL] [Abstract][Full Text] [Related]
5. A new class of multimerization selective inhibitors of HIV-1 integrase.
Sharma A; Slaughter A; Jena N; Feng L; Kessl JJ; Fadel HJ; Malani N; Male F; Wu L; Poeschla E; Bushman FD; Fuchs JR; Kvaratskhelia M
PLoS Pathog; 2014 May; 10(5):e1004171. PubMed ID: 24874515
[TBL] [Abstract][Full Text] [Related]
6. Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies.
Deng N; Hoyte A; Mansour YE; Mohamed MS; Fuchs JR; Engelman AN; Kvaratskhelia M; Levy R
Protein Sci; 2016 Nov; 25(11):1911-1917. PubMed ID: 27503276
[TBL] [Abstract][Full Text] [Related]
7. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.
Patel D; Antwi J; Koneru PC; Serrao E; Forli S; Kessl JJ; Feng L; Deng N; Levy RM; Fuchs JR; Olson AJ; Engelman AN; Bauman JD; Kvaratskhelia M; Arnold E
J Biol Chem; 2016 Nov; 291(45):23569-23577. PubMed ID: 27645997
[TBL] [Abstract][Full Text] [Related]
8. HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.
Koneru PC; Francis AC; Deng N; Rebensburg SV; Hoyte AC; Lindenberger J; Adu-Ampratwum D; Larue RC; Wempe MF; Engelman AN; Lyumkis D; Fuchs JR; Levy RM; Melikyan GB; Kvaratskhelia M
Elife; 2019 May; 8():. PubMed ID: 31120420
[TBL] [Abstract][Full Text] [Related]
9. Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.
Jurado KA; Wang H; Slaughter A; Feng L; Kessl JJ; Koh Y; Wang W; Ballandras-Colas A; Patel PA; Fuchs JR; Kvaratskhelia M; Engelman A
Proc Natl Acad Sci U S A; 2013 May; 110(21):8690-5. PubMed ID: 23610442
[TBL] [Abstract][Full Text] [Related]
10. The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.
Feng L; Dharmarajan V; Serrao E; Hoyte A; Larue RC; Slaughter A; Sharma A; Plumb MR; Kessl JJ; Fuchs JR; Bushman FD; Engelman AN; Griffin PR; Kvaratskhelia M
ACS Chem Biol; 2016 May; 11(5):1313-21. PubMed ID: 26910179
[TBL] [Abstract][Full Text] [Related]
11. A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.
Shkriabai N; Dharmarajan V; Slaughter A; Kessl JJ; Larue RC; Feng L; Fuchs JR; Griffin PR; Kvaratskhelia M
J Biol Chem; 2014 Sep; 289(38):26430-26440. PubMed ID: 25118283
[TBL] [Abstract][Full Text] [Related]
12. Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
Gupta K; Turkki V; Sherrill-Mix S; Hwang Y; Eilers G; Taylor L; McDanal C; Wang P; Temelkoff D; Nolte RT; Velthuisen E; Jeffrey J; Van Duyne GD; Bushman FD
PLoS Biol; 2016 Dec; 14(12):e1002584. PubMed ID: 27935939
[TBL] [Abstract][Full Text] [Related]
13. The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genome.
van Bel N; van der Velden Y; Bonnard D; Le Rouzic E; Das AT; Benarous R; Berkhout B
PLoS One; 2014; 9(7):e103552. PubMed ID: 25072705
[TBL] [Abstract][Full Text] [Related]
14. Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity.
Burlein C; Wang C; Xu M; Bhatt T; Stahlhut M; Ou Y; Adam GC; Heath J; Klein DJ; Sanders J; Narayan K; Abeywickrema P; Heo MR; Carroll SS; Grobler JA; Sharma S; Diamond TL; Converso A; Krosky DJ
ACS Chem Biol; 2017 Nov; 12(11):2858-2865. PubMed ID: 29024587
[TBL] [Abstract][Full Text] [Related]
15. Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs.
Naidu BN; Patel M; McAuliffe B; Ding B; Cianci C; Simmermacher J; Jenkins S; Parker DD; Sivaprakasam P; Khan JA; Kish K; Lewis H; Hanumegowda U; Krystal M; Meanwell NA; Kadow JF
J Med Chem; 2022 Mar; 65(6):4949-4971. PubMed ID: 35235334
[TBL] [Abstract][Full Text] [Related]
16. Indole-based allosteric inhibitors of HIV-1 integrase.
Patel PA; Kvaratskhelia N; Mansour Y; Antwi J; Feng L; Koneru P; Kobe MJ; Jena N; Shi G; Mohamed MS; Li C; Kessl JJ; Fuchs JR
Bioorg Med Chem Lett; 2016 Oct; 26(19):4748-4752. PubMed ID: 27568085
[TBL] [Abstract][Full Text] [Related]
17. Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase.
Kessl JJ; Sharma A; Kvaratskhelia M
Methods Mol Biol; 2016; 1354():149-64. PubMed ID: 26714710
[TBL] [Abstract][Full Text] [Related]
18. Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization.
Christ F; Shaw S; Demeulemeester J; Desimmie BA; Marchand A; Butler S; Smets W; Chaltin P; Westby M; Debyser Z; Pickford C
Antimicrob Agents Chemother; 2012 Aug; 56(8):4365-74. PubMed ID: 22664975
[TBL] [Abstract][Full Text] [Related]
19. Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity.
Wang C; Adam GC; Burlein C; Carroll S; Dankulich W; Diamond T; Grobler J; Heath J; Johnson A; Klein D; Krosky D; Narayan K; Ou Y; Sanders J; Sharma S; Xu M; Converso A
Bioorg Med Chem Lett; 2023 Jun; 89():129303. PubMed ID: 37146837
[TBL] [Abstract][Full Text] [Related]
20. Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors.
Singh PK; Li W; Bedwell GJ; Fadel HJ; Poeschla EM; Engelman AN
Viruses; 2022 Aug; 14(9):. PubMed ID: 36146690
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
