180 related articles for article (PubMed ID: 38399977)
21. Quinoline-based Protein-protein Interaction Inhibitors of LEDGF/p75 and HIV Integrase: An In Silico Study.
Chhokar N; Kalra S; Chauhan M; Munshi A; Kumar R
Curr Top Med Chem; 2018; 18(32):2800-2815. PubMed ID: 30747071
[TBL] [Abstract][Full Text] [Related]
22. The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.
Slaughter A; Jurado KA; Deng N; Feng L; Kessl JJ; Shkriabai N; Larue RC; Fadel HJ; Patel PA; Jena N; Fuchs JR; Poeschla E; Levy RM; Engelman A; Kvaratskhelia M
Retrovirology; 2014 Nov; 11():100. PubMed ID: 25421939
[TBL] [Abstract][Full Text] [Related]
23. Allosteric HIV Integrase Inhibitors Promote Formation of Inactive Branched Polymers via Homomeric Carboxy-Terminal Domain Interactions.
Gupta K; Allen A; Giraldo C; Eilers G; Sharp R; Hwang Y; Murali H; Cruz K; Janmey P; Bushman F; Van Duyne GD
Structure; 2021 Mar; 29(3):213-225.e5. PubMed ID: 33357410
[TBL] [Abstract][Full Text] [Related]
24. A Conformational Escape Reaction of HIV-1 against an Allosteric Integrase Inhibitor.
Nakamura T; Nakamura T; Amano M; Miyakawa T; Yamagata Y; Matsuoka M; Nakata H
J Virol; 2020 Sep; 94(19):. PubMed ID: 32611758
[TBL] [Abstract][Full Text] [Related]
25. Allosteric inhibition of HIV-1 integrase activity.
Engelman A; Kessl JJ; Kvaratskhelia M
Curr Opin Chem Biol; 2013 Jun; 17(3):339-45. PubMed ID: 23647983
[TBL] [Abstract][Full Text] [Related]
26. Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
Bonnard D; Le Rouzic E; Eiler S; Amadori C; Orlov I; Bruneau JM; Brias J; Barbion J; Chevreuil F; Spehner D; Chasset S; Ledoussal B; Moreau F; Saïb A; Klaholz BP; Emiliani S; Ruff M; Zamborlini A; Benarous R
J Biol Chem; 2018 Apr; 293(16):6172-6186. PubMed ID: 29507092
[TBL] [Abstract][Full Text] [Related]
27. Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.
Jurado KA; Engelman A
Expert Rev Mol Med; 2013 Nov; 15():e14. PubMed ID: 24274067
[TBL] [Abstract][Full Text] [Related]
28. Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 Å resolution: Routes to inhibitor optimization.
Eilers G; Gupta K; Allen A; Montermoso S; Murali H; Sharp R; Hwang Y; Bushman FD; Van Duyne G
PLoS Pathog; 2023 Mar; 19(3):e1011097. PubMed ID: 36867659
[TBL] [Abstract][Full Text] [Related]
29. The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function.
Singer MR; Dinh T; Levintov L; Annamalai AS; Rey JS; Briganti L; Cook NJ; Pye VE; Taylor IA; Kim K; Engelman AN; Kim B; Perilla JR; Kvaratskhelia M; Cherepanov P
mBio; 2023 Feb; 14(1):e0356022. PubMed ID: 36744954
[TBL] [Abstract][Full Text] [Related]
30. Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing.
Hoyte AC; Jamin AV; Koneru PC; Kobe MJ; Larue RC; Fuchs JR; Engelman AN; Kvaratskhelia M
J Biol Chem; 2017 Dec; 292(48):19814-19825. PubMed ID: 28972144
[TBL] [Abstract][Full Text] [Related]
31. Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.
Parcella K; Patel M; Tu Y; Eastman K; Peese K; Gillis E; Belema M; Dicker IB; McAuliffe B; Ding B; Falk P; Simmermacher J; Parker DD; Sivaprakasam P; Khan JA; Kish K; Lewis H; Hanumegowda U; Jenkins S; Kadow JF; Krystal M; Meanwell NA; Naidu BN
Bioorg Med Chem; 2022 Aug; 67():116833. PubMed ID: 35605346
[TBL] [Abstract][Full Text] [Related]
32. Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site.
Wielens J; Headey SJ; Jeevarajah D; Rhodes DI; Deadman J; Chalmers DK; Scanlon MJ; Parker MW
FEBS Lett; 2010 Apr; 584(8):1455-62. PubMed ID: 20227411
[TBL] [Abstract][Full Text] [Related]
33. Design, synthesis and SAR study of novel C2-pyrazolopyrimidine amides and amide isosteres as allosteric integrase inhibitors.
Patel M; Cianci C; Allard CW; Parker DD; Simmermacher J; Jenkins S; Mcauliffe B; Minassian B; Discotto L; Krystal M; Meanwell NA; Naidu BN
Bioorg Med Chem Lett; 2020 Nov; 30(21):127516. PubMed ID: 32860982
[TBL] [Abstract][Full Text] [Related]
34. Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells.
Madison MK; Lawson DQ; Elliott J; Ozantürk AN; Koneru PC; Townsend D; Errando M; Kvaratskhelia M; Kutluay SB
J Virol; 2017 Sep; 91(17):. PubMed ID: 28615207
[TBL] [Abstract][Full Text] [Related]
35. Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation.
Fontana J; Jurado KA; Cheng N; Ly NL; Fuchs JR; Gorelick RJ; Engelman AN; Steven AC
J Virol; 2015 Oct; 89(19):9765-80. PubMed ID: 26178982
[TBL] [Abstract][Full Text] [Related]
36. HIV-1 integrase multimerization as a therapeutic target.
Feng L; Larue RC; Slaughter A; Kessl JJ; Kvaratskhelia M
Curr Top Microbiol Immunol; 2015; 389():93-119. PubMed ID: 25778682
[TBL] [Abstract][Full Text] [Related]
37. Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.
Li G; Meanwell NA; Krystal MR; Langley DR; Naidu BN; Sivaprakasam P; Lewis H; Kish K; Khan JA; Ng A; Trainor GL; Cianci C; Dicker IB; Walker MA; Lin Z; Protack T; Discotto L; Jenkins S; Gerritz SW; Pendri A
J Med Chem; 2020 Mar; 63(5):2620-2637. PubMed ID: 32081010
[TBL] [Abstract][Full Text] [Related]
38. Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase.
Bonnard D; Le Rouzic E; Singer MR; Yu Z; Le Strat F; Batisse C; Batisse J; Amadori C; Chasset S; Pye VE; Emiliani S; Ledoussal B; Ruff M; Moreau F; Cherepanov P; Benarous R
Antimicrob Agents Chemother; 2023 Jul; 67(7):e0046223. PubMed ID: 37310224
[TBL] [Abstract][Full Text] [Related]
39. 3D-QSAR studies of quinoline ring derivatives as HIV-1 integrase inhibitors.
Sun XH; Guan JQ; Tan JJ; Liu C; Wang CX
SAR QSAR Environ Res; 2012 Oct; 23(7-8):683-703. PubMed ID: 22991976
[TBL] [Abstract][Full Text] [Related]
40. In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer.
Voet AR; Maeyer MD; Debyser Z; Christ F
Future Med Chem; 2009 Oct; 1(7):1259-74. PubMed ID: 21426102
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
