154 related articles for article (PubMed ID: 38401189)
1. Macrocycles and macrocyclization in anticancer drug discovery: Important pieces of the puzzle.
Zhang C; Liu F; Zhang Y; Song C
Eur J Med Chem; 2024 Mar; 268():116234. PubMed ID: 38401189
[TBL] [Abstract][Full Text] [Related]
2. Macrocyclization strategy for improving candidate profiles in medicinal chemistry.
Darlami O; Pun R; Ahn SH; Kim SH; Shin D
Eur J Med Chem; 2024 Jun; 272():116501. PubMed ID: 38754142
[TBL] [Abstract][Full Text] [Related]
3. Heterocycles: Versatile control elements in bioactive macrocycles.
Soor HS; Appavoo SD; Yudin AK
Bioorg Med Chem; 2018 Jun; 26(10):2774-2779. PubMed ID: 29735427
[TBL] [Abstract][Full Text] [Related]
4. Macrocycles in new drug discovery.
Mallinson J; Collins I
Future Med Chem; 2012 Jul; 4(11):1409-38. PubMed ID: 22857532
[TBL] [Abstract][Full Text] [Related]
5. Macrocyclization of linear molecules by deep learning to facilitate macrocyclic drug candidates discovery.
Diao Y; Liu D; Ge H; Zhang R; Jiang K; Bao R; Zhu X; Bi H; Liao W; Chen Z; Zhang K; Wang R; Zhu L; Zhao Z; Hu Q; Li H
Nat Commun; 2023 Jul; 14(1):4552. PubMed ID: 37507402
[TBL] [Abstract][Full Text] [Related]
6. Structure-Based Macrocycle Design in Small-Molecule Drug Discovery and Simple Metrics To Identify Opportunities for Macrocyclization of Small-Molecule Ligands.
Cummings MD; Sekharan S
J Med Chem; 2019 Aug; 62(15):6843-6853. PubMed ID: 30860377
[TBL] [Abstract][Full Text] [Related]
7. Macrocyclic Compounds: Emerging Opportunities for Current Drug Discovery.
You L; An R; Liang K; Cui B; Wang X
Curr Pharm Des; 2016; 22(26):4086-93. PubMed ID: 26845327
[TBL] [Abstract][Full Text] [Related]
8. Predicting bioactive conformations and binding modes of macrocycles.
Anighoro A; de la Vega de León A; Bajorath J
J Comput Aided Mol Des; 2016 Oct; 30(10):841-849. PubMed ID: 27655412
[TBL] [Abstract][Full Text] [Related]
9. Automated Design of Macrocycles for Therapeutic Applications: From Small Molecules to Peptides and Proteins.
Sindhikara D; Wagner M; Gkeka P; Güssregen S; Tiwari G; Hessler G; Yapici E; Li Z; Evers A
J Med Chem; 2020 Oct; 63(20):12100-12115. PubMed ID: 33017535
[TBL] [Abstract][Full Text] [Related]
10. Computational Macrocyclization: From de novo Macrocycle Generation to Binding Affinity Estimation.
Wagner V; Jantz L; Briem H; Sommer K; Rarey M; Christ CD
ChemMedChem; 2017 Nov; 12(22):1866-1872. PubMed ID: 28977738
[TBL] [Abstract][Full Text] [Related]
11. Synthetic Opportunities and Challenges for Macrocyclic Kinase Inhibitors.
Amrhein JA; Knapp S; Hanke T
J Med Chem; 2021 Jun; 64(12):7991-8009. PubMed ID: 34076436
[TBL] [Abstract][Full Text] [Related]
12. Protein epitope mimetic macrocycles as biopharmaceuticals.
Luther A; Moehle K; Chevalier E; Dale G; Obrecht D
Curr Opin Chem Biol; 2017 Jun; 38():45-51. PubMed ID: 28319811
[TBL] [Abstract][Full Text] [Related]
13. Accurate and Reliable Prediction of the Binding Affinities of Macrocycles to Their Protein Targets.
Yu HS; Deng Y; Wu Y; Sindhikara D; Rask AR; Kimura T; Abel R; Wang L
J Chem Theory Comput; 2017 Dec; 13(12):6290-6300. PubMed ID: 29120625
[TBL] [Abstract][Full Text] [Related]
14. The emerging role of computational design in peptide macrocycle drug discovery.
Mulligan VK
Expert Opin Drug Discov; 2020 Jul; 15(7):833-852. PubMed ID: 32345066
[TBL] [Abstract][Full Text] [Related]
15. Design, Properties and Recent Application of Macrocycles in Medicinal Chemistry.
Ermert P
Chimia (Aarau); 2017 Oct; 71(10):678-702. PubMed ID: 29070413
[TBL] [Abstract][Full Text] [Related]
16. Lead discovery and optimization strategies for peptide macrocycles.
Bhat A; Roberts LR; Dwyer JJ
Eur J Med Chem; 2015 Apr; 94():471-9. PubMed ID: 25109255
[TBL] [Abstract][Full Text] [Related]
17. An Insight into the Medicinal Chemistry Perspective of Macrocyclic Derivatives with Antitumor Activity: A Systematic Review.
Liang Y; Fang R; Rao Q
Molecules; 2022 Apr; 27(9):. PubMed ID: 35566196
[TBL] [Abstract][Full Text] [Related]
18. Macrocycles as potential therapeutic agents in neglected diseases.
Peña S; Scarone L; Serra G
Future Med Chem; 2015; 7(3):355-82. PubMed ID: 25650721
[TBL] [Abstract][Full Text] [Related]
19. Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs.
Olanders G; Brandt P; Sköld C; Karlén A
Bioorg Med Chem; 2021 Nov; 49():116399. PubMed ID: 34601455
[TBL] [Abstract][Full Text] [Related]
20. Structure-Based Design of a Macrocyclic PROTAC.
Testa A; Hughes SJ; Lucas X; Wright JE; Ciulli A
Angew Chem Int Ed Engl; 2020 Jan; 59(4):1727-1734. PubMed ID: 31746102
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
