126 related articles for article (PubMed ID: 38415431)
1. Application of fucosylation inhibitors for production of afucosylated antibody.
Xu P; Ou YC; Smith M; Paulson J; Schmidt MA; Kandari L; Parsons R; Khetan A
Biotechnol Prog; 2024; 40(3):e3438. PubMed ID: 38415431
[TBL] [Abstract][Full Text] [Related]
2. FX knockout CHO hosts can express desired ratios of fucosylated or afucosylated antibodies with high titers and comparable product quality.
Louie S; Haley B; Marshall B; Heidersbach A; Yim M; Brozynski M; Tang D; Lam C; Petryniak B; Shaw D; Shim J; Miller A; Lowe JB; Snedecor B; Misaghi S
Biotechnol Bioeng; 2017 Mar; 114(3):632-644. PubMed ID: 27666939
[TBL] [Abstract][Full Text] [Related]
3. A novel bicistronic gene design couples stable cell line selection with a fucose switch in a designer CHO host to produce native and afucosylated glycoform antibodies.
Roy G; Martin T; Barnes A; Wang J; Jimenez RB; Rice M; Li L; Feng H; Zhang S; Chaerkady R; Wu H; Marelli M; Hatton D; Zhu J; Bowen MA
MAbs; 2018 Apr; 10(3):416-430. PubMed ID: 29400603
[TBL] [Abstract][Full Text] [Related]
4. Generation of FX
Liu W; Padmashali R; Monzon OQ; Lundberg D; Jin S; Dwyer B; Lee YJ; Korde A; Park S; Pan C; Zhang B
Biotechnol Prog; 2021 Jan; 37(1):e3061. PubMed ID: 32748555
[TBL] [Abstract][Full Text] [Related]
5. A metabolic inhibitor blocks cellular fucosylation and enables production of afucosylated antibodies.
Gilormini PA; Thota VN; Fers-Lidou A; Ashmus RA; Nodwell M; Brockerman J; Kuo CW; Wang Y; Gray TE; Nitin ; McDonagh AW; Guu SY; Ertunc N; Yeo D; Zandberg WF; Khoo KH; Britton R; Vocadlo DJ
Proc Natl Acad Sci U S A; 2024 Jul; 121(27):e2314026121. PubMed ID: 38917011
[TBL] [Abstract][Full Text] [Related]
6. Interaction of cell culture process parameters for modulating mAb afucosylation.
Nguyen Dang A; Mun M; Rose CM; Ahyow P; Meier A; Sandoval W; Yuk IH
Biotechnol Bioeng; 2019 Apr; 116(4):831-845. PubMed ID: 30597531
[TBL] [Abstract][Full Text] [Related]
7. Use of 5-Thio-L-Fucose to modulate binding affinity of therapeutic proteins.
Zimmermann M; Nguyen M; Schultheiss CM; Kolmar H; Zimmer A
Biotechnol Bioeng; 2021 May; 118(5):1818-1831. PubMed ID: 33501689
[TBL] [Abstract][Full Text] [Related]
8. Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation.
Gong Q; Hazen M; Marshall B; Crowell SR; Ou Q; Wong AW; Phung W; Vernes JM; Meng YG; Tejada M; Andersen D; Kelley RF
MAbs; 2016; 8(6):1098-106. PubMed ID: 27216702
[TBL] [Abstract][Full Text] [Related]
9. Double knockdown of alpha1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC.
Imai-Nishiya H; Mori K; Inoue M; Wakitani M; Iida S; Shitara K; Satoh M
BMC Biotechnol; 2007 Nov; 7():84. PubMed ID: 18047682
[TBL] [Abstract][Full Text] [Related]
10. Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase.
Allen JG; Mujacic M; Frohn MJ; Pickrell AJ; Kodama P; Bagal D; San Miguel T; Sickmier EA; Osgood S; Swietlow A; Li V; Jordan JB; Kim KW; Rousseau AC; Kim YJ; Caille S; Achmatowicz M; Thiel O; Fotsch CH; Reddy P; McCarter JD
ACS Chem Biol; 2016 Oct; 11(10):2734-2743. PubMed ID: 27434622
[TBL] [Abstract][Full Text] [Related]
11. Engineering nucleotide sugar synthesis pathways for independent and simultaneous modulation of N-glycan galactosylation and fucosylation in CHO cells.
Prabhu A; Shanmugam D; Gadgil M
Metab Eng; 2022 Nov; 74():61-71. PubMed ID: 36152932
[TBL] [Abstract][Full Text] [Related]
12. Comparison of two glycoengineering strategies to control the fucosylation of a monoclonal antibody.
Mishra N; Spearman M; Donald L; Perreault H; Butler M
J Biotechnol; 2020; 324S():100015. PubMed ID: 34154738
[TBL] [Abstract][Full Text] [Related]
13. Production of non-fucosylated antibodies by co-expression of heterologous GDP-6-deoxy-D-lyxo-4-hexulose reductase.
von Horsten HH; Ogorek C; Blanchard V; Demmler C; Giese C; Winkler K; Kaup M; Berger M; Jordan I; Sandig V
Glycobiology; 2010 Dec; 20(12):1607-18. PubMed ID: 20639190
[TBL] [Abstract][Full Text] [Related]
14. Identifying the differences in mechanisms of mycophenolic acid controlling fucose content of glycoproteins expressed in different CHO cell lines.
Zhang A; Tsang VL; Markely LR; Kurt L; Huang YM; Prajapati S; Kshirsagar R
Biotechnol Bioeng; 2016 Nov; 113(11):2367-76. PubMed ID: 27093551
[TBL] [Abstract][Full Text] [Related]
15. Development of orally active inhibitors of protein and cellular fucosylation.
Okeley NM; Alley SC; Anderson ME; Boursalian TE; Burke PJ; Emmerton KM; Jeffrey SC; Klussman K; Law CL; Sussman D; Toki BE; Westendorf L; Zeng W; Zhang X; Benjamin DR; Senter PD
Proc Natl Acad Sci U S A; 2013 Apr; 110(14):5404-9. PubMed ID: 23493549
[TBL] [Abstract][Full Text] [Related]
16. Assessment of the role of afucosylated glycoforms on the
Kwiatkowski A; Co C; Kameoka S; Zhang A; Coughlin J; Cameron T; Chiao E; Bergelson S; Schmid Mason C
MAbs; 2020; 12(1):1803645. PubMed ID: 32812835
[TBL] [Abstract][Full Text] [Related]
17. Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose.
Ferrara C; Grau S; Jäger C; Sondermann P; Brünker P; Waldhauer I; Hennig M; Ruf A; Rufer AC; Stihle M; Umaña P; Benz J
Proc Natl Acad Sci U S A; 2011 Aug; 108(31):12669-74. PubMed ID: 21768335
[TBL] [Abstract][Full Text] [Related]
18. Detection and quantitation of afucosylated N-linked oligosaccharides in recombinant monoclonal antibodies using enzymatic digestion and LC-MS.
Du Y; May K; Xu W; Liu H
J Am Soc Mass Spectrom; 2012 Jul; 23(7):1241-9. PubMed ID: 22569911
[TBL] [Abstract][Full Text] [Related]
19. Strategies for controlling afucosylation in monoclonal antibodies during upstream manufacturing.
Rish AJ; Siddiquee K; Huang Z; Xu J; Anderson CA; Borys MC; Khetan A
Biotechnol J; 2023 Jul; 18(7):e2200604. PubMed ID: 37029472
[TBL] [Abstract][Full Text] [Related]
20. Application of the CRISPR/Cas9 Gene Editing Method for Modulating Antibody Fucosylation in CHO Cells.
Wang Q; Aliyu L; Chung CY; Rosenberg JN; Yu G; Betenbaugh MJ
Methods Mol Biol; 2024; 2810():249-271. PubMed ID: 38926284
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
