139 related articles for article (PubMed ID: 38428284)
1. Tailored quinoline hybrids as promising COX-2/15-LOX dual inhibitors endowed with diverse safety profile: Design, synthesis, SAR, and histopathological study.
Hegazy ME; Taher ES; Ghiaty AH; Bayoumi AH
Bioorg Chem; 2024 Apr; 145():107244. PubMed ID: 38428284
[TBL] [Abstract][Full Text] [Related]
2. Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition.
Ghanim AM; Rezq S; Ibrahim TS; Romero DG; Kothayer H
Eur J Med Chem; 2021 Jul; 219():113457. PubMed ID: 33892270
[TBL] [Abstract][Full Text] [Related]
3. New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.
El-Miligy MMM; Hazzaa AA; El-Messmary H; Nassra RA; El-Hawash SAM
Bioorg Chem; 2017 Jun; 72():102-115. PubMed ID: 28390993
[TBL] [Abstract][Full Text] [Related]
4. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes.
Maghraby MT; Abou-Ghadir OMF; Abdel-Moty SG; Ali AY; Salem OIA
Bioorg Med Chem; 2020 Apr; 28(7):115403. PubMed ID: 32127262
[TBL] [Abstract][Full Text] [Related]
5. Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids.
Abdu-Allah HHM; Abdelmoez AAB; Tarazi H; El-Shorbagi AA; El-Awady R
Bioorg Chem; 2020 Jan; 94():103378. PubMed ID: 31677858
[TBL] [Abstract][Full Text] [Related]
6. Discovery of new 2-(3-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazole derivatives with potential analgesic and anti-inflammatory activities: In vitro, in vivo and in silico investigations.
Mohammed ER; Abd-El-Fatah AH; Mohamed AR; Mahrouse MA; Mohammad MA
Bioorg Chem; 2024 Jun; 147():107372. PubMed ID: 38653152
[TBL] [Abstract][Full Text] [Related]
7. Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity.
Abdelrahman MH; Youssif BGM; Abdelgawad MA; Abdelazeem AH; Ibrahim HM; Moustafa AEGA; Treamblu L; Bukhari SNA
Eur J Med Chem; 2017 Feb; 127():972-985. PubMed ID: 27837994
[TBL] [Abstract][Full Text] [Related]
8. Synthesis, biological evaluation and docking study of 1,3,4-thiadiazole-thiazolidinone hybrids as anti-inflammatory agents with dual inhibition of COX-2 and 15-LOX.
Omar YM; Abdu-Allah HHM; Abdel-Moty SG
Bioorg Chem; 2018 Oct; 80():461-471. PubMed ID: 29986191
[TBL] [Abstract][Full Text] [Related]
9. Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE
Labib MB; Fayez AM; El-Nahass ES; Awadallah M; Halim PA
Bioorg Chem; 2020 Nov; 104():104308. PubMed ID: 33011534
[TBL] [Abstract][Full Text] [Related]
10. Novel N-substituted 5-aminosalicylamides as dual inhibitors of cyclooxygenase and 5-lipoxygenase enzymes: Synthesis, biological evaluation and docking study.
El-Nagar MKS; Abdu-Allah HHM; Salem OIA; Kafafy AN; Farghaly HSM
Bioorg Chem; 2018 Aug; 78():80-93. PubMed ID: 29550533
[TBL] [Abstract][Full Text] [Related]
11. Synthesis, anti-inflammatory screening, molecular docking, and COX-1,2/-5-LOX inhibition profile of some novel quinoline derivatives.
Chaaban I; Rizk OH; Ibrahim TM; Henen SS; El-Khawass EM; Bayad AE; El-Ashmawy IM; Nematalla HA
Bioorg Chem; 2018 Aug; 78():220-235. PubMed ID: 29602046
[TBL] [Abstract][Full Text] [Related]
12. New pyridazine derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents; design, synthesis and biological evaluation.
Ahmed EM; Hassan MSA; El-Malah AA; Kassab AE
Bioorg Chem; 2020 Jan; 95():103497. PubMed ID: 31838289
[TBL] [Abstract][Full Text] [Related]
13. Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and docking studies.
Abdelgawad MA; Labib MB; Ali WAM; Kamel G; Azouz AA; El-Nahass ES
Bioorg Chem; 2018 Aug; 78():103-114. PubMed ID: 29550530
[TBL] [Abstract][Full Text] [Related]
14. Novel 5,6-diphenyl-1,2,4-triazine-3-thiol derivatives as dual COX-2/5-LOX inhibitors devoid of cardiotoxicity.
Saraf P; Nath Tripathi P; Kumar Tripathi M; Tripathi A; Verma H; Kumar Waiker D; Singh R; Kumar Shrivastava S
Bioorg Chem; 2022 Dec; 129():106147. PubMed ID: 36126607
[TBL] [Abstract][Full Text] [Related]
15. Pyrazole-hydrazone derivatives as anti-inflammatory agents: Design, synthesis, biological evaluation, COX-1,2/5-LOX inhibition and docking study.
Abdelgawad MA; Labib MB; Abdel-Latif M
Bioorg Chem; 2017 Oct; 74():212-220. PubMed ID: 28865292
[TBL] [Abstract][Full Text] [Related]
16. Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with
El-Miligy MMM; Al-Kubeisi AK; Nassra RA; El-Zemity SR; Hazzaa AA
J Enzyme Inhib Med Chem; 2024 Dec; 39(1):2309171. PubMed ID: 38291670
[TBL] [Abstract][Full Text] [Related]
17. New benzothiophene derivatives as dual COX-1/2 and 5-LOX inhibitors: synthesis, biological evaluation and docking study.
El-Miligy MM; Hazzaa AA; El-Messmary H; Nassra RA; El-Hawash SA
Future Med Chem; 2017 Apr; 9(5):443-468. PubMed ID: 28362117
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors.
Gedawy EM; Kassab AE; El Kerdawy AM
Eur J Med Chem; 2020 Mar; 189():112066. PubMed ID: 31982653
[TBL] [Abstract][Full Text] [Related]
19. Novel 1,3-diaryl pyrazole derivatives bearing methylsulfonyl moiety: Design, synthesis, molecular docking and dynamics, with dual activities as anti-inflammatory and anticancer agents through selectively targeting COX-2.
Shaker AMM; Shahin MI; AboulMagd AM; Abdel Aleem SA; Abdel-Rahman HM; Abou El Ella DA
Bioorg Chem; 2022 Dec; 129():106143. PubMed ID: 36191430
[TBL] [Abstract][Full Text] [Related]
20. Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study.
Moussa G; Alaaeddine R; Alaeddine LM; Nassra R; Belal ASF; Ismail A; El-Yazbi AF; Abdel-Ghany YS; Hazzaa A
Eur J Med Chem; 2018 Jan; 144():635-650. PubMed ID: 29289887
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]