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8. Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation. Su YC; Qi X Hum Mol Genet; 2013 Nov; 22(22):4545-61. PubMed ID: 23813973 [TBL] [Abstract][Full Text] [Related]
9. In vivo susceptibility to energy failure parkinsonism and LRRK2 kinase activity. Novello S; Mercatelli D; Albanese F; Domenicale C; Brugnoli A; D'Aversa E; Vantaggiato S; Dovero S; Murtaj V; Presotto L; Borgatti M; Shimshek DR; Bezard E; Moresco RM; Belloli S; Morari M Neurobiol Dis; 2022 Jan; 162():105579. PubMed ID: 34871735 [TBL] [Abstract][Full Text] [Related]
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13. MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition. Fell MJ; Mirescu C; Basu K; Cheewatrakoolpong B; DeMong DE; Ellis JM; Hyde LA; Lin Y; Markgraf CG; Mei H; Miller M; Poulet FM; Scott JD; Smith MD; Yin Z; Zhou X; Parker EM; Kennedy ME; Morrow JA J Pharmacol Exp Ther; 2015 Dec; 355(3):397-409. PubMed ID: 26407721 [TBL] [Abstract][Full Text] [Related]
14. Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity. Nguyen APT; Tsika E; Kelly K; Levine N; Chen X; West AB; Boularand S; Barneoud P; Moore DJ Proc Natl Acad Sci U S A; 2020 Jul; 117(29):17296-17307. PubMed ID: 32631998 [TBL] [Abstract][Full Text] [Related]
15. Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging. Longo F; Russo I; Shimshek DR; Greggio E; Morari M Neurobiol Dis; 2014 Nov; 71():62-73. PubMed ID: 25107341 [TBL] [Abstract][Full Text] [Related]
17. LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction. Sanders LH; Laganière J; Cooper O; Mak SK; Vu BJ; Huang YA; Paschon DE; Vangipuram M; Sundararajan R; Urnov FD; Langston JW; Gregory PD; Zhang HS; Greenamyre JT; Isacson O; Schüle B Neurobiol Dis; 2014 Feb; 62():381-6. PubMed ID: 24148854 [TBL] [Abstract][Full Text] [Related]
18. Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo. Kluss JH; Mazza MC; Li Y; Manzoni C; Lewis PA; Cookson MR; Mamais A Mol Neurodegener; 2021 Mar; 16(1):17. PubMed ID: 33741046 [TBL] [Abstract][Full Text] [Related]
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