BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

189 related articles for article (PubMed ID: 38464138)

  • 1. Suppressing APOE4-induced mortality and cellular damage by targeting VHL.
    Jiang WI; Cao Y; Xue Y; Ji Y; Winer BY; Zhang M; Singhal NS; Pierce JT; Chen S; Ma DK
    bioRxiv; 2024 May; ():. PubMed ID: 38464138
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Von Hippel-Lindau (VHL) small-molecule inhibitor binding increases stability and intracellular levels of VHL protein.
    Frost J; Rocha S; Ciulli A
    J Biol Chem; 2021 Aug; 297(2):100910. PubMed ID: 34174286
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease.
    Zatyka M; da Silva NF; Clifford SC; Morris MR; Wiesener MS; Eckardt KU; Houlston RS; Richards FM; Latif F; Maher ER
    Cancer Res; 2002 Jul; 62(13):3803-11. PubMed ID: 12097293
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.
    Krieg M; Haas R; Brauch H; Acker T; Flamme I; Plate KH
    Oncogene; 2000 Nov; 19(48):5435-43. PubMed ID: 11114720
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Suppressive effects of iron chelation in clear cell renal cell carcinoma and their dependency on VHL inactivation.
    Greene CJ; Sharma NJ; Fiorica PN; Forrester E; Smith GJ; Gross KW; Kauffman EC
    Free Radic Biol Med; 2019 Mar; 133():295-309. PubMed ID: 30553971
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Endolymphatic sac tumors in patients with and without von Hippel-Lindau disease: the role of genetic mutation, von Hippel-Lindau protein, and hypoxia inducible factor-1alpha expression.
    Jensen RL; Gillespie D; House P; Layfield L; Shelton C
    J Neurosurg; 2004 Mar; 100(3):488-97. PubMed ID: 15035285
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1.
    Shen C; Shao Z; Powell-Coffman JA
    Genetics; 2006 Nov; 174(3):1205-14. PubMed ID: 16980385
    [TBL] [Abstract][Full Text] [Related]  

  • 8. von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.
    Hoffman MA; Ohh M; Yang H; Klco JM; Ivan M; Kaelin WG
    Hum Mol Genet; 2001 May; 10(10):1019-27. PubMed ID: 11331612
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice.
    Rankin EB; Higgins DF; Walisser JA; Johnson RS; Bradfield CA; Haase VH
    Mol Cell Biol; 2005 Apr; 25(8):3163-72. PubMed ID: 15798202
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2α/C-MYC axis under hypoxia.
    Zhai W; Sun Y; Jiang M; Wang M; Gasiewicz TA; Zheng J; Chang C
    Oncogene; 2016 Sep; 35(37):4866-80. PubMed ID: 26973243
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans.
    Bishop T; Lau KW; Epstein AC; Kim SK; Jiang M; O'Rourke D; Pugh CW; Gleadle JM; Taylor MS; Hodgkin J; Ratcliffe PJ
    PLoS Biol; 2004 Oct; 2(10):e289. PubMed ID: 15361934
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans.
    Shen C; Nettleton D; Jiang M; Kim SK; Powell-Coffman JA
    J Biol Chem; 2005 May; 280(21):20580-8. PubMed ID: 15781453
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function.
    German P; Bai S; Liu XD; Sun M; Zhou L; Kalra S; Zhang X; Minelli R; Scott KL; Mills GB; Jonasch E; Ding Z
    Oncogene; 2016 Sep; 35(38):4973-80. PubMed ID: 26973240
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein.
    Tanimoto K; Makino Y; Pereira T; Poellinger L
    EMBO J; 2000 Aug; 19(16):4298-309. PubMed ID: 10944113
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Action of hypoxia-inducible factor in liver and kidney from mice with Pax8-rtTA-based deletion of von Hippel-Lindau protein.
    Mathia S; Paliege A; Koesters R; Peters H; Neumayer HH; Bachmann S; Rosenberger C
    Acta Physiol (Oxf); 2013 Mar; 207(3):565-76. PubMed ID: 23384425
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas.
    Na X; Wu G; Ryan CK; Schoen SR; di'Santagnese PA; Messing EM
    J Urol; 2003 Aug; 170(2 Pt 1):588-92. PubMed ID: 12853836
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Leu-574 of HIF-1alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway.
    Huang LE; Pete EA; Schau M; Milligan J; Gu J
    J Biol Chem; 2002 Nov; 277(44):41750-5. PubMed ID: 12205091
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition.
    Chintala S; Najrana T; Toth K; Cao S; Durrani FA; Pili R; Rustum YM
    BMC Cancer; 2012 Jul; 12():293. PubMed ID: 22804960
    [TBL] [Abstract][Full Text] [Related]  

  • 19. von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis.
    Hickey MM; Lam JC; Bezman NA; Rathmell WK; Simon MC
    J Clin Invest; 2007 Dec; 117(12):3879-89. PubMed ID: 17992257
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation.
    Formenti F; Beer PA; Croft QP; Dorrington KL; Gale DP; Lappin TR; Lucas GS; Maher ER; Maxwell PH; McMullin MF; O'Connor DF; Percy MJ; Pugh CW; Ratcliffe PJ; Smith TG; Talbot NP; Robbins PA
    FASEB J; 2011 Jun; 25(6):2001-11. PubMed ID: 21389259
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.