133 related articles for article (PubMed ID: 38502780)
1. Identification of Novel Series of Potent and Selective Relaxin Family Peptide Receptor 1 (RXFP1) Agonists.
Granberg KL; Sakamaki S; Fuchigami R; Niwa Y; Fujio M; Kato H; Bergström F; Larsson N; Persson M; Villar IC; Fujita T; Sugikawa E; Althage M; Yano N; Yokoyama Y; Kimura J; Lal M; Mochida H
J Med Chem; 2024 Mar; 67(6):4442-4462. PubMed ID: 38502780
[TBL] [Abstract][Full Text] [Related]
2. Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists.
Hu X; Myhr C; Huang Z; Xiao J; Barnaeva E; Ho BA; Agoulnik IU; Ferrer M; Marugan JJ; Southall N; Agoulnik AI
Biochemistry; 2016 Mar; 55(12):1772-83. PubMed ID: 26866459
[TBL] [Abstract][Full Text] [Related]
3. ML290 is a biased allosteric agonist at the relaxin receptor RXFP1.
Kocan M; Sarwar M; Ang SY; Xiao J; Marugan JJ; Hossain MA; Wang C; Hutchinson DS; Samuel CS; Agoulnik AI; Bathgate RAD; Summers RJ
Sci Rep; 2017 Jun; 7(1):2968. PubMed ID: 28592882
[TBL] [Abstract][Full Text] [Related]
4. Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1.
Agoulnik AI; Agoulnik IU; Hu X; Marugan J
Br J Pharmacol; 2017 May; 174(10):977-989. PubMed ID: 27771940
[TBL] [Abstract][Full Text] [Related]
5. In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis.
McBride A; Hoy AM; Bamford MJ; Mossakowska DE; Ruediger MP; Griggs J; Desai S; Simpson K; Caballero-Hernandez I; Iredale JP; Pell T; Aucott RL; Holmes DS; Webster SP; Fallowfield JA
Sci Rep; 2017 Sep; 7(1):10806. PubMed ID: 28883402
[TBL] [Abstract][Full Text] [Related]
6. R2R01: A long-acting single-chain peptide agonist of RXFP1 for renal and cardiovascular diseases.
Poirier B; Pasquier O; Chenede X; Corbier A; Prigent P; Azam A; Bernard C; Guillotel M; Gillot F; Riva L; Briand V; Ingenito R; Gauzy-Lazo L; Duclos O; Philippo C; Maillere B; Bianchi E; Mallart S; Janiak P; Illiano S
Br J Pharmacol; 2024 Jul; 181(13):1993-2011. PubMed ID: 38450758
[TBL] [Abstract][Full Text] [Related]
7. Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases.
Mallart S; Ingenito R; Bianchi E; Bresciani A; Esposito S; Gallo M; Magotti P; Monteagudo E; Orsatti L; Roversi D; Santoprete A; Tucci F; Veneziano M; Bartsch R; Boehm C; Brasseur D; Bruneau P; Corbier A; Froissant J; Gauzy-Lazo L; Gervat V; Marguet F; Menguy I; Minoletti C; Nicolas MF; Pasquier O; Poirier B; Raux A; Riva L; Janiak P; Strobel H; Duclos O; Illiano S
J Med Chem; 2021 Feb; 64(4):2139-2150. PubMed ID: 33555858
[TBL] [Abstract][Full Text] [Related]
8. Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure.
Granberg KL; Sakamaki S; Larsson N; Bergström F; Fuchigami R; Niwa Y; Ryberg E; Backmark A; Kato H; Miyazaki S; Iguchi K; Sakamoto T; Persson M; Idei A; Prieto Garcia L; Villar IC; Gradén H; Bergonzini G; Arvidsson T; Fujita T; Althage M; Ulander J; Kimura J; Yoneda H; Fjellström O; Mochida H; Lal M
J Med Chem; 2024 Mar; 67(6):4419-4441. PubMed ID: 38502782
[TBL] [Abstract][Full Text] [Related]
9. Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models.
Illiano S; Poirier B; Minoletti C; Pasquier O; Riva L; Chenede X; Menguy I; Guillotel M; Prigent P; Le Claire S; Gillot F; Thill G; Lo Presti F; Corbier A; Le Bail JC; Grailhe P; Monteagudo E; Ingenito R; Bianchi E; Philippo C; Duclos O; Mallart S; Bathgate R; Janiak P
Sci Rep; 2022 Nov; 12(1):20435. PubMed ID: 36443381
[TBL] [Abstract][Full Text] [Related]
10. Chimeric relaxin peptides highlight the role of the A-chain in the function of H2 relaxin.
Hossain MA; Wade JD; Bathgate RA
Peptides; 2012 May; 35(1):102-6. PubMed ID: 22414484
[TBL] [Abstract][Full Text] [Related]
11. Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay.
Chen CZ; Southall N; Xiao J; Marugan JJ; Ferrer M; Hu X; Jones RE; Feng S; Agoulnik IU; Zheng W; Agoulnik AI
J Biomol Screen; 2013 Jul; 18(6):670-7. PubMed ID: 23212924
[TBL] [Abstract][Full Text] [Related]
12. Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis.
Kaftanovskaya EM; Ng HH; Soula M; Rivas B; Myhr C; Ho BA; Cervantes BA; Shupe TD; Devarasetty M; Hu X; Xu X; Patnaik S; Wilson KJ; Barnaeva E; Ferrer M; Southall NT; Marugan JJ; Bishop CE; Agoulnik IU; Agoulnik AI
FASEB J; 2019 Nov; 33(11):12435-12446. PubMed ID: 31419161
[TBL] [Abstract][Full Text] [Related]
13. Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290.
Huang Z; Myhr C; Bathgate RA; Ho BA; Bueno A; Hu X; Xiao J; Southall N; Barnaeva E; Agoulnik IU; Marugan JJ; Ferrer M; Agoulnik AI
Front Endocrinol (Lausanne); 2015; 6():128. PubMed ID: 26347712
[TBL] [Abstract][Full Text] [Related]
14. Probing the functional domains of relaxin-3 and the creation of a selective antagonist for RXFP3/GPCR135 over relaxin receptor RXFP1/LGR7.
Liu C; Kuei C; Sutton S; Shelton J; Zhu J; Nepomuceno D; Hossain MA; Wade JD; Bathgate RA; Bonaventure P; Lovenberg T
Ann N Y Acad Sci; 2009 Apr; 1160():31-7. PubMed ID: 19416155
[TBL] [Abstract][Full Text] [Related]
15. Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1.
Xiao J; Huang Z; Chen CZ; Agoulnik IU; Southall N; Hu X; Jones RE; Ferrer M; Zheng W; Agoulnik AI; Marugan JJ
Nat Commun; 2013; 4():1953. PubMed ID: 23764525
[TBL] [Abstract][Full Text] [Related]
16. Single chain peptide agonists of relaxin receptors.
Praveen P; Kocan M; Valkovic A; Bathgate R; Hossain MA
Mol Cell Endocrinol; 2019 May; 487():34-39. PubMed ID: 30641102
[TBL] [Abstract][Full Text] [Related]
17. Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile.
Wilson KJ; Xiao J; Chen CZ; Huang Z; Agoulnik IU; Ferrer M; Southall N; Hu X; Zheng W; Xu X; Wang A; Myhr C; Barnaeva E; George ER; Agoulnik AI; Marugan JJ
Eur J Med Chem; 2018 Aug; 156():79-92. PubMed ID: 30006176
[TBL] [Abstract][Full Text] [Related]
18. Investigation of interactions at the extracellular loops of the relaxin family peptide receptor 1 (RXFP1).
Diepenhorst NA; Petrie EJ; Chen CZ; Wang A; Hossain MA; Bathgate RA; Gooley PR
J Biol Chem; 2014 Dec; 289(50):34938-52. PubMed ID: 25352603
[TBL] [Abstract][Full Text] [Related]
19. Human Relaxin Receptor Is Fully Functional in Humanized Mice and Is Activated by Small Molecule Agonist ML290.
Kaftanovskaya EM; Soula M; Myhr C; Ho BA; Moore SN; Yoo C; Cervantes B; How J; Marugan J; Agoulnik IU; Agoulnik AI
J Endocr Soc; 2017 Jun; 1(6):712-725. PubMed ID: 28825052
[TBL] [Abstract][Full Text] [Related]
20.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
[Next] [New Search]
