BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

146 related articles for article (PubMed ID: 38536918)

  • 41. Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors.
    Singh A; Venkannagari S; Oh KH; Zhang YQ; Rohde JM; Liu L; Nimmagadda S; Sudini K; Brimacombe KR; Gajghate S; Ma J; Wang A; Xu X; Shahane SA; Xia M; Woo J; Mensah GA; Wang Z; Ferrer M; Gabrielson E; Li Z; Rastinejad F; Shen M; Boxer MB; Biswal S
    ACS Chem Biol; 2016 Nov; 11(11):3214-3225. PubMed ID: 27552339
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases.
    Pallesen JS; Tran KT; Bach A
    J Med Chem; 2018 Sep; 61(18):8088-8103. PubMed ID: 29750408
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Mild Oxidative Stress Reduces NRF2 SUMOylation to Promote
    Xu J; Guo H; Xing Z; Zhang W; He J; Cheng J; Cai R
    Oxid Med Cell Longev; 2020; 2020():6240125. PubMed ID: 33299528
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
    Zhou HS; Hu LB; Zhang H; Shan WX; Wang Y; Li X; Liu T; Zhao J; You QD; Jiang ZY
    J Med Chem; 2020 Oct; 63(19):11149-11168. PubMed ID: 32902980
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.
    Romero R; Sayin VI; Davidson SM; Bauer MR; Singh SX; LeBoeuf SE; Karakousi TR; Ellis DC; Bhutkar A; Sánchez-Rivera FJ; Subbaraj L; Martinez B; Bronson RT; Prigge JR; Schmidt EE; Thomas CJ; Goparaju C; Davies A; Dolgalev I; Heguy A; Allaj V; Poirier JT; Moreira AL; Rudin CM; Pass HI; Vander Heiden MG; Jacks T; Papagiannakopoulos T
    Nat Med; 2017 Nov; 23(11):1362-1368. PubMed ID: 28967920
    [TBL] [Abstract][Full Text] [Related]  

  • 46. Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
    Davies TG; Wixted WE; Coyle JE; Griffiths-Jones C; Hearn K; McMenamin R; Norton D; Rich SJ; Richardson C; Saxty G; Willems HM; Woolford AJ; Cottom JE; Kou JP; Yonchuk JG; Feldser HG; Sanchez Y; Foley JP; Bolognese BJ; Logan G; Podolin PL; Yan H; Callahan JF; Heightman TD; Kerns JK
    J Med Chem; 2016 Apr; 59(8):3991-4006. PubMed ID: 27031670
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Medicinal Chemistry Insights into the Development of Small-Molecule Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
    Zhao Z; Dong R; You Q; Jiang Z
    J Med Chem; 2023 Jul; 66(14):9325-9344. PubMed ID: 37441735
    [TBL] [Abstract][Full Text] [Related]  

  • 48. Role of NRF2 in Lung Cancer.
    Sánchez-Ortega M; Carrera AC; Garrido A
    Cells; 2021 Jul; 10(8):. PubMed ID: 34440648
    [TBL] [Abstract][Full Text] [Related]  

  • 49. Thioredoxin reductase-1 levels are associated with NRF2 pathway activation and tumor recurrence in non-small cell lung cancer.
    Delgobo M; Gonçalves RM; Delazeri MA; Falchetti M; Zandoná A; Nascimento das Neves R; Almeida K; Fagundes AC; Gelain DP; Fracasso JI; Macêdo GB; Priori L; Bassani N; Bishop AJR; Forcelini CM; Moreira JCF; Zanotto-Filho A
    Free Radic Biol Med; 2021 Dec; 177():58-71. PubMed ID: 34673143
    [TBL] [Abstract][Full Text] [Related]  

  • 50. Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors.
    Mou Y; Wen S; Li YX; Gao XX; Zhang X; Jiang ZY
    Eur J Med Chem; 2020 Sep; 202():112532. PubMed ID: 32668381
    [TBL] [Abstract][Full Text] [Related]  

  • 51. Activation of the Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor 2 (Nrf2) pathway through covalent modification of the 2-alkenal group of aliphatic electrophiles in Coriandrum sativum L.
    Abiko Y; Mizokawa M; Kumagai Y
    J Agric Food Chem; 2014 Nov; 62(45):10936-44. PubMed ID: 25307732
    [TBL] [Abstract][Full Text] [Related]  

  • 52. Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis.
    Sakai E; Morita M; Ohuchi M; Kido MA; Fukuma Y; Nishishita K; Okamoto K; Itoh K; Yamamoto M; Tsukuba T
    FASEB J; 2017 Sep; 31(9):4011-4022. PubMed ID: 28515152
    [TBL] [Abstract][Full Text] [Related]  

  • 53. ZJ01, a Small Molecule Inhibitor of the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction, Reduces Hyperoxic Acute Lung Injury in a Mouse Model.
    Wan J; Lin S; Huang X; Li Q; Zeng L; Du S
    Med Sci Monit; 2020 May; 26():e920467. PubMed ID: 32437336
    [TBL] [Abstract][Full Text] [Related]  

  • 54. Nrf2-Keap1 antioxidant defense and cell survival signaling are upregulated by 17β-estradiol in homocysteine-treated dopaminergic SH-SY5Y cells.
    Chen CS; Tseng YT; Hsu YY; Lo YC
    Neuroendocrinology; 2013; 97(3):232-41. PubMed ID: 22948038
    [TBL] [Abstract][Full Text] [Related]  

  • 55. Inhibitors of Keap1-Nrf2 protein-protein interaction reduce estrogen responsive gene expression and oxidative stress in estrogen receptor-positive breast cancer.
    Xie T; Zahid H; Ali AR; Joyce R; Yang G; Winz C; Le Y; Zhou R; Furmanski P; Hu L; Suh N
    Toxicol Appl Pharmacol; 2023 Feb; 460():116375. PubMed ID: 36634873
    [TBL] [Abstract][Full Text] [Related]  

  • 56. Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition.
    Hamada S; Matsumoto R; Tanaka Y; Taguchi K; Yamamoto M; Masamune A
    Int J Mol Sci; 2021 Feb; 22(4):. PubMed ID: 33672789
    [TBL] [Abstract][Full Text] [Related]  

  • 57. Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress.
    Suzuki T; Yamamoto M
    J Biol Chem; 2017 Oct; 292(41):16817-16824. PubMed ID: 28842501
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells.
    Deen AJ; Adinolfi S; Härkönen J; Patinen T; Liu X; Laitinen T; Takabe P; Kainulainen K; Pasonen-Seppänen S; Gawriyski LM; Arasu UT; Selvarajan I; Mäkinen P; Laitinen H; Kansanen E; Kaikkonen MU; Poso A; Varjosalo M; Levonen AL
    Redox Biol; 2024 Feb; 69():103031. PubMed ID: 38184997
    [TBL] [Abstract][Full Text] [Related]  

  • 59. Nestin regulates cellular redox homeostasis in lung cancer through the Keap1-Nrf2 feedback loop.
    Wang J; Lu Q; Cai J; Wang Y; Lai X; Qiu Y; Huang Y; Ke Q; Zhang Y; Guan Y; Wu H; Wang Y; Liu X; Shi Y; Zhang K; Wang M; Peng Xiang A
    Nat Commun; 2019 Nov; 10(1):5043. PubMed ID: 31695040
    [TBL] [Abstract][Full Text] [Related]  

  • 60. Microenvironmental Activation of Nrf2 Restricts the Progression of Nrf2-Activated Malignant Tumors.
    Hayashi M; Kuga A; Suzuki M; Panda H; Kitamura H; Motohashi H; Yamamoto M
    Cancer Res; 2020 Aug; 80(16):3331-3344. PubMed ID: 32636316
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.