BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

156 related articles for article (PubMed ID: 38542866)

  • 1. Discovery of Novel Noncovalent KRAS G12D Inhibitors through Structure-Based Virtual Screening and Molecular Dynamics Simulations.
    Du Z; Tu G; Gong Y; Fu X; Wu Q; Long G
    Molecules; 2024 Mar; 29(6):. PubMed ID: 38542866
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of New KRAS G12D Inhibitors through Computer-Aided Drug Discovery Methods.
    Kulkarni AM; Kumar V; Parate S; Lee G; Yoon S; Lee KW
    Int J Mol Sci; 2022 Jan; 23(3):. PubMed ID: 35163234
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS
    Wang X; Allen S; Blake JF; Bowcut V; Briere DM; Calinisan A; Dahlke JR; Fell JB; Fischer JP; Gunn RJ; Hallin J; Laguer J; Lawson JD; Medwid J; Newhouse B; Nguyen P; O'Leary JM; Olson P; Pajk S; Rahbaek L; Rodriguez M; Smith CR; Tang TP; Thomas NC; Vanderpool D; Vigers GP; Christensen JG; Marx MA
    J Med Chem; 2022 Feb; 65(4):3123-3133. PubMed ID: 34889605
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of Potential Inhibitors Targeting GTPase-Kirsten RAt Sarcoma Virus (K-Ras) Driven Cancers via E-Pharmacophore-Based Virtual Screening and Drug Repurposing Approach.
    Kumar S U; Varghese RP; Preethi VA; Doss CGP; Zayed H
    Front Biosci (Landmark Ed); 2023 Nov; 28(11):288. PubMed ID: 38062837
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of novel peptide inhibitors for oncogenic KRAS G12D as therapeutic options using mutagenesis-based remodeling and MD simulations.
    Samad A; Khurshid B; Mahmood A; Rehman AU; Khalid A; Abdalla AN; Algarni AS; Wadood A
    J Biomol Struct Dyn; 2023; 41(22):13425-13437. PubMed ID: 37010994
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pharmacophoric analogs of sotorasib-entrapped KRAS G12C in its inactive GDP-bound conformation: covalent docking and molecular dynamics investigations.
    Oyedele AK; Ogunlana AT; Boyenle ID; Ibrahim NO; Gbadebo IO; Owolabi NA; Ayoola AM; Francis AC; Eyinade OH; Adelusi TI
    Mol Divers; 2023 Aug; 27(4):1795-1807. PubMed ID: 36271195
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovering and Targeting Dynamic Drugging Pockets of Oncogenic Proteins: The Role of Magnesium in Conformational Changes of the G12D Mutated Kirsten Rat Sarcoma-Guanosine Diphosphate Complex.
    Hu Z; Marti J
    Int J Mol Sci; 2022 Nov; 23(22):. PubMed ID: 36430338
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition mechanism of MRTX1133 on KRAS
    Liang F; Kang Z; Sun X; Chen J; Duan X; He H; Cheng J
    J Comput Aided Mol Des; 2023 Mar; 37(3):157-166. PubMed ID: 36849761
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of potent and noncovalent KRAS
    Wang Y; Zhang H; Li J; Niu MM; Zhou Y; Qu Y
    Front Pharmacol; 2022; 13():1094887. PubMed ID: 36618907
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Salvianolic acid F suppresses KRAS-dependent lung cancer cell growth through the PI3K/AKT signaling pathway.
    Hou X; Zhou C; Liang Z; Qiu H; Zhou Z; Zheng H; Li Z; Wang Y; Qi X; Lu L; Cao Y; Zheng J
    Phytomedicine; 2023 Dec; 121():155093. PubMed ID: 37783131
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of the binding of MRTX1133 as an avenue for the discovery of potential KRAS
    Issahaku AR; Mukelabai N; Agoni C; Rudrapal M; Aldosari SM; Almalki SG; Khan J
    Sci Rep; 2022 Oct; 12(1):17796. PubMed ID: 36273239
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of potential inhibitor targeting KRAS mutation in Papillary Thyroid Carcinoma through molecular docking and dynamic simulation analysis.
    Tayubi IA; Madar IH
    Comput Biol Med; 2023 Jan; 152():106377. PubMed ID: 36493736
    [TBL] [Abstract][Full Text] [Related]  

  • 13. KRAS inhibitors: going noncovalent.
    Drosten M; Barbacid M
    Mol Oncol; 2022 Dec; 16(22):3911-3915. PubMed ID: 36383067
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Computational investigation to identify potent inhibitors of the GTPase-Kirsten RAt sarcoma virus (K-Ras) mutants G12C and G12D.
    Kumar SU; Priya Doss CG
    Comput Biol Med; 2021 Dec; 139():104946. PubMed ID: 34715554
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery.
    Ramalingam PS; Balakrishnan P; Rajendran S; Jothi A; Ramalingam R; Arumugam S
    Curr Issues Mol Biol; 2023 Mar; 45(3):2136-2156. PubMed ID: 36975507
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of Thieno[2,3-d]pyrimidine-based KRAS G12D inhibitors as potential anticancer agents via combinatorial virtual screening.
    Li L; Liu J; Yang Z; Zhao H; Deng B; Ren Y; Mai R; Huang J; Chen J
    Eur J Med Chem; 2022 Apr; 233():114243. PubMed ID: 35276423
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Computational analysis of KRAS mutations: implications for different effects on the KRAS p.G12D and p.G13D mutations.
    Chen CC; Er TK; Liu YY; Hwang JK; Barrio MJ; Rodrigo M; Garcia-Toro E; Herreros-Villanueva M
    PLoS One; 2013; 8(2):e55793. PubMed ID: 23437064
    [TBL] [Abstract][Full Text] [Related]  

  • 18. New lead compounds identification against KRas mediated cancers through pharmacophore-based virtual screening and in vitro assays.
    Ghufran M; Rehman AU; Ayaz M; Ul-Haq Z; Uddin R; Azam SS; Wadood A
    J Biomol Struct Dyn; 2023; 41(16):8053-8067. PubMed ID: 36184737
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Computational study of novel natural inhibitors targeting Kirsten rat sarcoma viral oncogene homolog G12C.
    Yang W; Ge J; Yuan M; Li J; Pan L; Ren J; Dou G; Yang L; Zhou Y; Xie H; Wang X; Hu H
    Anticancer Drugs; 2023 Jun; 34(5):609-619. PubMed ID: 36847041
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cetuximab Enhances the Efficacy of MRTX1133, a Novel KRAS
    Kataoka M; Kitazawa M; Nakamura S; Koyama M; Yamamoto Y; Miyazaki S; Hondo N; Tanaka H; Soejima Y
    Anticancer Res; 2023 Oct; 43(10):4341-4348. PubMed ID: 37772552
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.