BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 38556190)

  • 1. DDX3X overexpression decreases dipeptide repeat proteins in a mouse model of C9ORF72-ALS/FTD.
    Fu X; Zhang Z; Hayes LR; Wright N; Asbury J; Li S; Ye Y; Sun S
    Exp Neurol; 2024 Jun; 376():114768. PubMed ID: 38556190
    [TBL] [Abstract][Full Text] [Related]  

  • 2. CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation.
    Cheng W; Wang S; Zhang Z; Morgens DW; Hayes LR; Lee S; Portz B; Xie Y; Nguyen BV; Haney MS; Yan S; Dong D; Coyne AN; Yang J; Xian F; Cleveland DW; Qiu Z; Rothstein JD; Shorter J; Gao FB; Bassik MC; Sun S
    Neuron; 2019 Dec; 104(5):885-898.e8. PubMed ID: 31587919
    [TBL] [Abstract][Full Text] [Related]  

  • 3. C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.
    Beckers J; Tharkeshwar AK; Van Damme P
    Autophagy; 2021 Nov; 17(11):3306-3322. PubMed ID: 33632058
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model.
    Nguyen L; Montrasio F; Pattamatta A; Tusi SK; Bardhi O; Meyer KD; Hayes L; Nakamura K; Banez-Coronel M; Coyne A; Guo S; Laboissonniere LA; Gu Y; Narayanan S; Smith B; Nitsch RM; Kankel MW; Rushe M; Rothstein J; Zu T; Grimm J; Ranum LPW
    Neuron; 2020 Feb; 105(4):645-662.e11. PubMed ID: 31831332
    [TBL] [Abstract][Full Text] [Related]  

  • 5. UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model.
    Zhang K; Wang A; Zhong K; Qi S; Wei C; Shu X; Tu WY; Xu W; Xia C; Xiao Y; Chen A; Bai L; Zhang J; Luo B; Wang W; Shen C
    Neuron; 2021 Jun; 109(12):1949-1962.e6. PubMed ID: 33991504
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice.
    Peters OM; Cabrera GT; Tran H; Gendron TF; McKeon JE; Metterville J; Weiss A; Wightman N; Salameh J; Kim J; Sun H; Boylan KB; Dickson D; Kennedy Z; Lin Z; Zhang YJ; Daughrity L; Jung C; Gao FB; Sapp PC; Horvitz HR; Bosco DA; Brown SP; de Jong P; Petrucelli L; Mueller C; Brown RH
    Neuron; 2015 Dec; 88(5):902-909. PubMed ID: 26637797
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features.
    Shaw MP; Higginbottom A; McGown A; Castelli LM; James E; Hautbergue GM; Shaw PJ; Ramesh TM
    Acta Neuropathol Commun; 2018 Nov; 6(1):125. PubMed ID: 30454072
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD.
    Esanov R; Cabrera GT; Andrade NS; Gendron TF; Brown RH; Benatar M; Wahlestedt C; Mueller C; Zeier Z
    Mol Neurodegener; 2017 Jun; 12(1):46. PubMed ID: 28606110
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Insights into C9ORF72-Related ALS/FTD from Drosophila and iPSC Models.
    Yuva-Aydemir Y; Almeida S; Gao FB
    Trends Neurosci; 2018 Jul; 41(7):457-469. PubMed ID: 29729808
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene.
    Wen X; Westergard T; Pasinelli P; Trotti D
    Neurosci Lett; 2017 Jan; 636():16-26. PubMed ID: 27619540
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Therapeutic reduction of GGGGCC repeat RNA levels by hnRNPA3 suppresses neurodegeneration in Drosophila models of C9orf72-linked ALS/FTD.
    Taminato T; Takeuchi T; Ueyama M; Mori K; Ikeda M; Mochizuki H; Nagai Y
    Hum Mol Genet; 2023 May; 32(10):1673-1682. PubMed ID: 36611007
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G
    Czuppa M; Dhingra A; Zhou Q; Schludi C; König L; Scharf E; Farny D; Dalmia A; Täger J; Castillo-Lizardo M; Katona E; Mori K; Aumer T; Schelter F; Müller M; Carell T; Kalliokoski T; Messinger J; Rizzu P; Heutink P; Edbauer D
    Cell Rep; 2022 Jun; 39(10):110913. PubMed ID: 35675776
    [TBL] [Abstract][Full Text] [Related]  

  • 13. CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro.
    Meijboom KE; Abdallah A; Fordham NP; Nagase H; Rodriguez T; Kraus C; Gendron TF; Krishnan G; Esanov R; Andrade NS; Rybin MJ; Ramic M; Stephens ZD; Edraki A; Blackwood MT; Kahriman A; Henninger N; Kocher JA; Benatar M; Brodsky MH; Petrucelli L; Gao FB; Sontheimer EJ; Brown RH; Zeier Z; Mueller C
    Nat Commun; 2022 Oct; 13(1):6286. PubMed ID: 36271076
    [TBL] [Abstract][Full Text] [Related]  

  • 14. C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation.
    Licata NV; Cristofani R; Salomonsson S; Wilson KM; Kempthorne L; Vaizoglu D; D'Agostino VG; Pollini D; Loffredo R; Pancher M; Adami V; Bellosta P; Ratti A; Viero G; Quattrone A; Isaacs AM; Poletti A; Provenzani A
    EMBO J; 2022 Jan; 41(1):e105026. PubMed ID: 34791698
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesis.
    Suzuki H; Shibagaki Y; Hattori S; Matsuoka M
    Cell Death Dis; 2018 Sep; 9(10):975. PubMed ID: 30250194
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inflammasome-Mediated Neuronal-Microglial Crosstalk: a Therapeutic Substrate for the Familial C9orf72 Variant of Frontotemporal Dementia/Amyotrophic Lateral Sclerosis.
    Trageser KJ; Yang EJ; Smith C; Iban-Arias R; Oguchi T; Sebastian-Valverde M; Iqbal UH; Wu H; Estill M; Al Rahim M; Raval U; Herman FJ; Zhang YJ; Petrucelli L; Pasinetti GM
    Mol Neurobiol; 2023 Jul; 60(7):4004-4016. PubMed ID: 37010807
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes.
    Nelson AT; Cicardi ME; Markandaiah SS; Han JY; Philp NJ; Welebob E; Haeusler AR; Pasinelli P; Manfredi G; Kawamata H; Trotti D
    EMBO Rep; 2024 May; 25(5):2479-2510. PubMed ID: 38684907
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Repeated repeat problems: Combinatorial effect of C9orf72-derived dipeptide repeat proteins.
    Darling AL; Breydo L; Rivas EG; Gebru NT; Zheng D; Baker JD; Blair LJ; Dickey CA; Koren J; Uversky VN
    Int J Biol Macromol; 2019 Apr; 127():136-145. PubMed ID: 30639592
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis.
    Saberi S; Stauffer JE; Jiang J; Garcia SD; Taylor AE; Schulte D; Ohkubo T; Schloffman CL; Maldonado M; Baughn M; Rodriguez MJ; Pizzo D; Cleveland D; Ravits J
    Acta Neuropathol; 2018 Mar; 135(3):459-474. PubMed ID: 29196813
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Repeat length increases disease penetrance and severity in C9orf72 ALS/FTD BAC transgenic mice.
    Pattamatta A; Nguyen L; Olafson HR; Scotti MM; Laboissonniere LA; Richardson J; Berglund JA; Zu T; Wang ET; Ranum LPW
    Hum Mol Genet; 2021 Feb; 29(24):3900-3918. PubMed ID: 33378537
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.