140 related articles for article (PubMed ID: 38597264)
21. Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
Tron AE; Belmonte MA; Adam A; Aquila BM; Boise LH; Chiarparin E; Cidado J; Embrey KJ; Gangl E; Gibbons FD; Gregory GP; Hargreaves D; Hendricks JA; Johannes JW; Johnstone RW; Kazmirski SL; Kettle JG; Lamb ML; Matulis SM; Nooka AK; Packer MJ; Peng B; Rawlins PB; Robbins DW; Schuller AG; Su N; Yang W; Ye Q; Zheng X; Secrist JP; Clark EA; Wilson DM; Fawell SE; Hird AW
Nat Commun; 2018 Dec; 9(1):5341. PubMed ID: 30559424
[TBL] [Abstract][Full Text] [Related]
22. BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-X
Greaves G; Milani M; Butterworth M; Carter RJ; Byrne DP; Eyers PA; Luo X; Cohen GM; Varadarajan S
Cell Death Differ; 2019 Jun; 26(6):1037-1047. PubMed ID: 30185825
[TBL] [Abstract][Full Text] [Related]
23. Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer.
Lee T; Christov PP; Shaw S; Tarr JC; Zhao B; Veerasamy N; Jeon KO; Mills JJ; Bian Z; Sensintaffar JL; Arnold AL; Fogarty SA; Perry E; Ramsey HE; Cook RS; Hollingshead M; Davis Millin M; Lee KM; Koss B; Budhraja A; Opferman JT; Kim K; Arteaga CL; Moore WJ; Olejniczak ET; Savona MR; Fesik SW
J Med Chem; 2019 Apr; 62(8):3971-3988. PubMed ID: 30929420
[TBL] [Abstract][Full Text] [Related]
24. Recent Advances in the Development of Selective Mcl-1 Inhibitors for the Treatment of Cancer (2017-Present).
Fan Y; Hou X; Fang H
Recent Pat Anticancer Drug Discov; 2020; 15(4):306-320. PubMed ID: 32938354
[TBL] [Abstract][Full Text] [Related]
25. Discovery of β-carboline copper(II) complexes as Mcl-1 inhibitor and in vitro and in vivo activity in cancer models.
Lu X; Liu YC; Orvig C; Liang H; Chen ZF
Eur J Med Chem; 2019 Nov; 181():111567. PubMed ID: 31401535
[TBL] [Abstract][Full Text] [Related]
26. Small interfering RNA targeting mcl-1 enhances proteasome inhibitor-induced apoptosis in various solid malignant tumors.
Zhou W; Hu J; Tang H; Wang D; Huang X; He C; Zhu H
BMC Cancer; 2011 Nov; 11():485. PubMed ID: 22078414
[TBL] [Abstract][Full Text] [Related]
27. Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold.
Niu Q; Deng H; Zhang Z; Xu Q; Luan S; Huang M; Liu D; Zhao L
Bioorg Med Chem Lett; 2021 Sep; 47():128215. PubMed ID: 34153472
[TBL] [Abstract][Full Text] [Related]
28. Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).
Leverson JD; Zhang H; Chen J; Tahir SK; Phillips DC; Xue J; Nimmer P; Jin S; Smith M; Xiao Y; Kovar P; Tanaka A; Bruncko M; Sheppard GS; Wang L; Gierke S; Kategaya L; Anderson DJ; Wong C; Eastham-Anderson J; Ludlam MJ; Sampath D; Fairbrother WJ; Wertz I; Rosenberg SH; Tse C; Elmore SW; Souers AJ
Cell Death Dis; 2015 Jan; 6(1):e1590. PubMed ID: 25590800
[TBL] [Abstract][Full Text] [Related]
29. Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains.
Wan Y; Liu T; Li X; Chen C; Fang H
Bioorg Med Chem; 2017 Jan; 25(1):138-152. PubMed ID: 27810438
[TBL] [Abstract][Full Text] [Related]
30. Interdiction at a protein-protein interface: MCL-1 inhibitors for oncology.
Li K
Bioorg Med Chem Lett; 2021 Jan; 32():127717. PubMed ID: 33253879
[TBL] [Abstract][Full Text] [Related]
31. Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.
Pan R; Ruvolo VR; Wei J; Konopleva M; Reed JC; Pellecchia M; Andreeff M; Ruvolo PP
Blood; 2015 Jul; 126(3):363-72. PubMed ID: 26045609
[TBL] [Abstract][Full Text] [Related]
32. Pharmacologic Targeting of Mcl-1 Induces Mitochondrial Dysfunction and Apoptosis in B-Cell Lymphoma Cells in a
Liu T; Lam V; Thieme E; Sun D; Wang X; Xu F; Wang L; Danilova OV; Xia Z; Tyner JW; Kurtz SE; Danilov AV
Clin Cancer Res; 2021 Sep; 27(17):4910-4922. PubMed ID: 34233959
[TBL] [Abstract][Full Text] [Related]
33. Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival.
Eichhorn JM; Alford SE; Sakurikar N; Chambers TC
Exp Cell Res; 2014 Apr; 322(2):415-24. PubMed ID: 24556425
[TBL] [Abstract][Full Text] [Related]
34. Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer.
Goodwin CM; Rossanese OW; Olejniczak ET; Fesik SW
Cell Death Differ; 2015 Dec; 22(12):2098-106. PubMed ID: 26045046
[TBL] [Abstract][Full Text] [Related]
35. Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members.
Opferman JT
FEBS J; 2016 Jul; 283(14):2661-75. PubMed ID: 26293580
[TBL] [Abstract][Full Text] [Related]
36. Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis.
Varadarajan S; Butterworth M; Wei J; Pellecchia M; Dinsdale D; Cohen GM
Neoplasia; 2013 May; 15(5):568-78. PubMed ID: 23633928
[TBL] [Abstract][Full Text] [Related]
37. Key Survival Factor, Mcl-1, Correlates with Sensitivity to Combined Bcl-2/Bcl-xL Blockade.
Williams MM; Lee L; Hicks DJ; Joly MM; Elion D; Rahman B; McKernan C; Sanchez V; Balko JM; Stricker T; Estrada MV; Cook RS
Mol Cancer Res; 2017 Mar; 15(3):259-268. PubMed ID: 28039357
[TBL] [Abstract][Full Text] [Related]
38. DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis.
Milani M; Byrne DP; Greaves G; Butterworth M; Cohen GM; Eyers PA; Varadarajan S
Cell Death Dis; 2017 Jan; 8(1):e2552. PubMed ID: 28079887
[TBL] [Abstract][Full Text] [Related]
39. Discovery of a Copper-Based Mcl-1 Inhibitor as an Effective Antitumor Agent.
Lu X; Liu YC; Orvig C; Liang H; Chen ZF
J Med Chem; 2020 Sep; 63(17):9154-9167. PubMed ID: 32794745
[TBL] [Abstract][Full Text] [Related]
40. Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression.
Doi K; Liu Q; Gowda K; Barth BM; Claxton D; Amin S; Loughran TP; Wang HG
Cancer Biol Ther; 2014 Aug; 15(8):1077-86. PubMed ID: 24842334
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
