BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

177 related articles for article (PubMed ID: 38622112)

  • 1. Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase.
    Blomgren LKM; Huber M; Mackinnon SR; Bürer C; Baslé A; Yue WW; Froese DS; McCorvie TJ
    Nat Commun; 2024 Apr; 15(1):3248. PubMed ID: 38622112
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one-carbon metabolism.
    Bhatia M; Thakur J; Suyal S; Oniel R; Chakraborty R; Pradhan S; Sharma M; Sengupta S; Laxman S; Masakapalli SK; Bachhawat AK
    J Biol Chem; 2020 Nov; 295(47):16037-16057. PubMed ID: 32934008
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.
    Froese DS; Kopec J; Rembeza E; Bezerra GA; Oberholzer AE; Suormala T; Lutz S; Chalk R; Borkowska O; Baumgartner MR; Yue WW
    Nat Commun; 2018 Jun; 9(1):2261. PubMed ID: 29891918
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase.
    Zheng Y; Ramsamooj S; Li Q; Johnson JL; Yaron TM; Sharra K; Cantley LC
    Sci Rep; 2019 Mar; 9(1):4190. PubMed ID: 30862944
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain.
    Bezerra GA; Holenstein A; Foster WR; Xie B; Hicks KG; Bürer C; Lutz S; Mukherjee A; Sarkar D; Bhattacharya D; Rutter J; Talukdar A; Brown PJ; Luo M; Shi L; Froese DS; Yue WW
    Biochimie; 2021 Apr; 183():100-107. PubMed ID: 33476699
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutational landscape screening of methylene tetrahydrofolate reductase to predict homocystinuria associated variants: An integrative computational approach.
    Nagarajan H; Narayanaswamy S; Vetrivel U
    Mutat Res; 2020; 819-820():111687. PubMed ID: 31968288
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women.
    Barbosa PR; Stabler SP; Machado AL; Braga RC; Hirata RD; Hirata MH; Sampaio-Neto LF; Allen RH; Guerra-Shinohara EM
    Eur J Clin Nutr; 2008 Aug; 62(8):1010-21. PubMed ID: 17522601
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Methylenetetrahydrofolate reductase modulates methyl metabolism and lignin monomer methylation in maize.
    Wu Z; Ren H; Xiong W; Roje S; Liu Y; Su K; Fu C
    J Exp Bot; 2018 Jul; 69(16):3963-3973. PubMed ID: 29860438
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Properties and crystal structure of methylenetetrahydrofolate reductase from Thermus thermophilus HB8.
    Igari S; Ohtaki A; Yamanaka Y; Sato Y; Yohda M; Odaka M; Noguchi K; Yamada K
    PLoS One; 2011; 6(8):e23716. PubMed ID: 21858212
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 5,10-Methylenetetrahydrofolate reductase becomes phosphorylated during meiotic maturation in mouse oocytes.
    Young K; Tscherner AK; Zhang B; Meredith M; McClatchie T; Trasler JM; Baltz JM
    Zygote; 2022 Oct; 30(5):674-688. PubMed ID: 35652653
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Thymidylate synthase gene polymorphisms and markers of DNA methylation capacity.
    Ho V; Massey TE; King WD
    Mol Genet Metab; 2011 Apr; 102(4):481-7. PubMed ID: 21269855
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Regulation of human methylenetetrahydrofolate reductase by phosphorylation.
    Yamada K; Strahler JR; Andrews PC; Matthews RG
    Proc Natl Acad Sci U S A; 2005 Jul; 102(30):10454-9. PubMed ID: 16024724
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity.
    Yamada K; Mendoza J; Koutmos M
    J Biol Chem; 2023 Feb; 299(2):102855. PubMed ID: 36592927
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The effect of troglitazone on plasma homocysteine, hepatic and red blood cell S-adenosyl methionine, and S-adenosyl homocysteine and enzymes in homocysteine metabolism in Zucker rats.
    Fonseca V; Keebler M; Dicker-Brown A; Desouza C; Poirier LA; Murthy SN; McNamara DB
    Metabolism; 2002 Jun; 51(6):783-6. PubMed ID: 12037736
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G polymorphisms influence on leukocyte genomic DNA methylation level.
    Weiner AS; Boyarskikh UA; Voronina EN; Mishukova OV; Filipenko ML
    Gene; 2014 Jan; 533(1):168-72. PubMed ID: 24103477
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Methylation status in healthy subjects with normal and high serum folate concentration.
    Hirsch S; Ronco AM; Guerrero-Bosagna C; de la Maza MP; Leiva L; Barrera G; Llanos M; Alliende MA; Silva F; Bunout D
    Nutrition; 2008; 24(11-12):1103-9. PubMed ID: 18653314
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The importance of preconception Hcy testing: identification of a folate trap syndrome in a woman attending an assisted reproduction program.
    Clément A; Clément P; Viot G; Menezo YJR
    J Assist Reprod Genet; 2023 Dec; 40(12):2879-2883. PubMed ID: 37819550
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The impact of pre-pregnancy folic acid intake on placental DNA methylation in a fortified cohort.
    van Otterdijk SD; Klett H; Boerries M; Michels KB
    FASEB J; 2023 Jan; 37(1):e22698. PubMed ID: 36520012
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Blood S-adenosylmethionine concentrations and lymphocyte methylenetetrahydrofolate reductase activity in diabetes mellitus and diabetic nephropathy.
    Poirier LA; Brown AT; Fink LM; Wise CK; Randolph CJ; Delongchamp RR; Fonseca VA
    Metabolism; 2001 Sep; 50(9):1014-8. PubMed ID: 11555831
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Body mass index is an important determinant of methylation biomarkers in women of reproductive ages.
    van Driel LM; Eijkemans MJ; de Jonge R; de Vries JH; van Meurs JB; Steegers EA; Steegers-Theunissen RP
    J Nutr; 2009 Dec; 139(12):2315-21. PubMed ID: 19812220
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.